1
Robert L Dow, Kevin Koch, Gary R Schulte: 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors. Pfizer, Peter C Richardson, Gregg C Benson, A Dean Olson, January 14, 1997: US05593997 (138 worldwide citation)

Certain 4-aminopyrazolo[3,4-d]pyrimidine compounds, and their pharmaceutically-acceptable salts and prodrugs, are inhibitors of tyrosine kinase enzymes and are useful for immunoregulation and for the treatment of cancer, angiogenesis and atherosclerosis.


2
Frederick J Ehrgott, Carl J Goddard, Gary R Schulte: 3-substituted-2-oxindole derivatives. Pfizer, Peter C Richardson, J Trevor Lumb, Gregg C Benson, September 10, 1991: US05047554 (18 worldwide citation)

This invention relates to novel 3-substituted-2-oxindole derivatives which are inhibitors of prostaglandin H.sub.2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. The compounds of the invention are useful as inhibitors of prostaglandin H.sub.2 synthase and interleukin-1 biosynthesis, per se ...


3
Gary R Schulte: Use of rapamycin prodrugs as immunosuppressant agents. Pfizer, Peter C Richardson, Paul H Ginsburg, Grover F Fuller Jr, July 11, 1995: US05432183 (14 worldwide citation)

The use of rapamycin prodrugs of formula I as immunosuppressant agents, intermediates formed in the preparation of its prodrugs as well as the prodrugs themselves. ##STR1##


4
Frederick J Ehrgott, Carl J Goddard, Gary R Schulte: 2-carboxy-thiophene derivatives. Pfizer, Peter C Richardson, Gregg C Benson, April 5, 1994: US05300655 (7 worldwide citation)

This invention relates to novel 3-substituted-2-oxindole derivatives which are inhibitors of prostaglandin H.sub.2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. The compounds of the invention are useful as inhibitors of prostaglandin H.sub.2 synthase and interleukin-1 biosynthesis, per se ...


5
Frederick J Ehrgott, Carl J Goddard, Gary R Schulte: 3-substituted-2-oxindole derivatives. Pfizer, Peter C Richardson, Gregg C Benson, March 1, 1994: US05290802 (5 worldwide citation)

This invention relates to novel 3-substituted-2-oxindole derivatives which are inhibitors of prostaglandin H.sub.2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. The compounds of the invention are useful as inhibitors of prostaglandin H.sub.2 synthase and interleukin-1 biosynthesis, per se ...


6
James R Hauske, Gary R Schulte: Desosamino derivatives of macrolides as immunosuppressants and antifungal agents. Pfizer, Peter C Richardson, Gregg C Benson, Robert T Ronau, April 9, 1996: US05506233 (5 worldwide citation)

Macrolides of the FK-506 type and methods of treatment of resistance to transplantation, fungal infections, and autoimmune diseases such as rheumatoid arthritis and psoriasis using said macrolides.


7
Carl J Goddard, Gary R Schulte: 3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use. Pfizer, Peter C Richardson, J Trevor Lumb, Gregg C Benson, November 12, 1991: US05064851 (2 worldwide citation)

This invention relates to novel 3-(1-substituted-pyrazoyl)-2-oxindole derivatives which are inhibitors of prostaglandin H.sub.2 synthease, 5-lipoxygenase and interleukin-1 biosynthesis. The compounds of the invention are useful as inhibitors of prostaglandin H.sub.2 synthase and interleukin-1 biosyn ...


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9
Laurence E Burgess, Gary R Schulte: Regioselective synthesis of 4-chloro-2-thiophenecarboxylic acid. Pfizer, Peter C Richardson, Gregg C Benson, James T Jones, July 15, 1997: US05648502 (1 worldwide citation)

4-Chloro-2-thiophenecarboxylic acid is made by forming a compound of formula (Ia), disclosed herein, wherein R.sup.3 is (C.sub.1 -C.sub.6) alkyl, phenyl, or benzyl; converting the compound to a compound of formula (IVa), disclosed herein, and removing the silyl group R.sub.3 Si--. The product is use ...


10
Kevin Koch, Gary R Schulte: 2-Aminosugar derivatives of macrolides. Pfizer, Peter C Richardson, Gregg C Benson, Robert T Ronau, May 20, 1997: US05631235 (1 worldwide citation)

Macrolides of formula (I) and methods of treatment of resistance to transplantation, fungal infections and autoimmune diseases such as rheumatoid arthritis and psoriasis using said macrolides of formula (I), wherein n is 1 or 2; A and B are taken together and form .dbd.O or A and B are taken separat ...