1
Philip L Felgner, Jon A Wolff, Gary H Rhodes, Robert W Malone, Dennis A Carson: Delivery of exogenous DNA sequences in a mammal. VICAL Incorporated, Wisconsin Alumni Research Foundation, Knobbe Martens Olson & Bear, December 3, 1996: US05580859 (762 worldwide citation)

Polynucleotide sequences, comprising DNA and RNA molecules can be directly administered, for example by injection, to tissues, such as muscle, and expressed as a protein, polypeptide or polypeptide. The polynucleotides can be contained within liposomes or the polynucleotides can free from associatio ...


2
Philip L Felgner, Jon A Wolff, Gary H Rhodes, Robert W Malone, Dennis A Carson: Induction of a protective immune response in a mammal by injecting a DNA sequence. Vical Incorporated, Wisconsin Alumni Research Foundation, Knobbe Martens Olson & Bear, December 31, 1996: US05589466 (546 worldwide citation)

A method for delivering an isolated polynucleotide such as DNA or RNA, to the interior of a cell in a mammal comprising the injection of an isolated polynucleotide into a muscle of the mammal where the polynucleotide is taken up by the cells of the muscle and exerts a therapeutic effect on the mamma ...


3
Philip L Felgner, Jon Asher Wolff, Gary H Rhodes, Robert Wallace Malone, Dennis A Carson: Induction of a protective immune response in a mammal by injecting a DNA sequence. Vical Incorporated, Sterne Kesseler Goldstein & Fox P L L C, April 10, 2001: US06214804 (273 worldwide citation)

A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the ...


4
Philip L Felgner, Jon Asher Wolff, Gary H Rhodes, Robert Wallace Malone, Dennis A Carson: Generation of antibodies through lipid mediated DNA delivery. Wisconsin Alumni Research Foundation, Vical Incorporated, Knobbe Martens Olson & Bear, December 30, 1997: US05703055 (253 worldwide citation)

A method is disclosed for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic e ...


5
Philip L Felgner, Jon Asher Wolff, Gary H Rhodes, Robert Wallace Malone, Dennis A Carson: Methods of delivering a physiologically active polypeptide to a mammal. Vical, Wisconsin Alumni Research Foundation, Sterne Kessler Goldtein & Fox P L L C, July 2, 2002: US06413942 (89 worldwide citation)

A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the ...


6
Philip L Felgner, Jon Asher Wolff, Gary H Rhodes, Robert Wallace Malone, Dennis A Carson: Generation of an immune response to a pathogen. Vical Incorporated, Wisconsin Alumni Research Foundation, Sterne Kessler Goldstein & Fox P L L C, March 23, 2004: US06710035 (17 worldwide citation)

A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the ...


7
Philip L Felgner, Jon A Wolff, Gary H Rhodes, Robert Wallace Malone, Dennis A Carson: Lipid-mediated polynucleotide administration to deliver a biologically active peptide and to induce a cellular immune response. Vical Incorporated, Wisconsin Alumni Research Foundation, Sterne Kessler Goldstein & Fox P L L C, July 31, 2007: US07250404 (16 worldwide citation)

A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the ...


8
Philip L Felgner, Jon Asher Wolff, Gary H Rhodes, Robert Wallace Malone, Dennis A Carson: Lipid-mediated polynucleotide administration to reduce likelihood of subjects becoming infected. Vical Incorporated, Sterne Kessler Goldstein & Fox PLLC, March 15, 2005: US06867195 (9 worldwide citation)

A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the ...


9
Philip L Felgner, Jon Asher Wolff, Gary H Rhodes, Robert Wallace Malone, Dennis A Carson: Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human. Vical Incorporated, Wisconsin Alumni Research Foundation, Sterne Kessler Goldstein & Fox P L L C, January 6, 2004: US06673776 (3 worldwide citation)

A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the ...


10
Philip L Felgner, Jon Asher Wolff, Gary H Rhodes, Robert Wallace Malone, Dennis A Carson: Lipid-mediated polynucleotide administration to deliver a biologically active peptide and to induce a cellular immune response. Vical Incorporated, Sterne Kessler Goldstein & Fox Pllc, February 13, 2003: US20030032615-A1 (2 worldwide citation)

A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the ...