1
Leon W M M Terstappen, Galla Chandra Rao, Jonathan W Uhr, Emilian V Racila, Paul A Liberti: Methods and reagents for the rapid and efficient isolation of circulating cancer cells. Immunivest Corporation, Board of Regents The University of Texas System, Dann Dorfman Herrell and Skillman, April 2, 2002: US06365362 (162 worldwide citation)

A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell or less in 1 ml of blood and has a greater s ...


2
Leon W M M Terstappen, Galla Chandra Rao, Jonathan W Uhr, Emilian V Racila, Paul A Liberti: Methods and reagents for the rapid and efficient isolation of circulating cancer cells. Immunivest Corporation, Dann Dorfman Herrell and Skillman, November 11, 2003: US06645731 (106 worldwide citation)

A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell or less in 1 ml of blood and has a greater s ...


3
Galla Chandra Rao, Paul A Liberti: Surface immobilization of magnetically collected materials. Immunivest Corporation, Dann Dorfman Herrell and Skillman, August 26, 1997: US05660990 (70 worldwide citation)

A method for determining the presence and/or concentration of a target substance e.g. protein, nucleic acid, bioparticle etc. in a fluid sample is provided. The method disclosed combines elements of immunoassays, coated cup assays and magnetic particle separation to effect the quantitation and recov ...


4
Leon W M M Terstappen, Galla Chandra Rao, Jonathan W Uhr, Emilian V Racila, Paul A Liberti: Methods and reagents for the rapid and efficient isolation of circulating cancer cells. Immunivest Corporation, Joseph F Aceto, James L Wilcox, February 19, 2008: US07332288 (48 worldwide citation)

A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell or less in 1 ml of blood and has a greater s ...


5
Michael Kagan, Galla Chandra Rao, Jerry Prohaska, Tor Alden: Upon a cartridge for containing a specimen sample for optical analysis. Immunivest Corporation, Joseph F Aceto, James L Wilcox, March 14, 2006: US07011794 (38 worldwide citation)

An improved cartridge for holding a fluid sample with a small volume is disclosed herein. The cartridge has a test chamber and a vestibule through which the test fluids are inserted into the test chamber. Improved grips are flared-out to aid manipulation. The handle portion is reinforced to prevent ...


6
Galla Chandra Rao, Christopher Larson, Madeline Repollet, Herman Rutner, Leon W M M Terstappen, Shawn Mark O Hara, Steven Gross: Analysis of circulating tumor cells, fragments, and debris. Veridex, January 4, 2011: US07863012 (36 worldwide citation)

The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CellSpotterĀ® fluorescent microscopy imaging system. Analyzing damaged cells has shown ...


7
Galla Chandra Rao, Leon Terstappen, Paul Liberti: Methods for enhancing binding interactions between members of specific binding pairs. Immunivest Corporation, Dann Dorfman Herrell and Skillman, April 22, 2003: US06551843 (35 worldwide citation)

Disclosed is a method that improves the efficiency of reactions between specific binding pairs. By translating one member of the pair through a suspension of the second member, or across a surface to which the second member is immobilized, collision and binding frequencies are greatly increased. The ...


8
Mark Carle Connelly, Gerald V Doyle, Galla Chandra Rao, Leon W M M Terstappen: Method for assessing disease states by profile analysis of isolated circulating endothelial cells. Veridex, March 8, 2011: US07901950 (33 worldwide citation)

Elevated number of Circulating Endothelial Cells (CEC) have been implicated in disease conditions associated with the formation or destruction of blood vessels such as acute coronary syndrome, thrombocytopenic purpura, sickle cell disease, sepsis, lupus, nephrotic syndromes, rejection of organ trans ...


9
Michael Kagan, Galla Chandra Rao, Jerry Prohaska, Tor Alden: Cartridge for containing a specimen sample for optical analysis. Veridex, October 19, 2010: US07815863 (30 worldwide citation)

An improved cartridge for holding a fluid sample with a small volume is disclosed herein. The cartridge has a test chamber and a vestibule through which the test fluids are inserted into the test chamber. Improved grips are flared-out to aid manipulation. The handle portion is reinforced to prevent ...


10
Galla Chandra Rao, Herman Rutner: Labeled cell sets for use as functional controls in rare cell detection assays. Immunivest Corporation, Joseph F Aceto Esq, James L Wilcox Esq, October 16, 2007: US07282350 (27 worldwide citation)

Methods and kits for used as an internal or external control in rare cell analysis are disclosed. A plurality of fluorescently distinct sets of cells is used to define a range to assess the isolation of rare target cells from a sample. Thus, a known number of cells, expressing the surface and intrac ...