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Gale Eugene Smith, Franklin Volvovitz, Bethanie Eident Wilkinson, Craig Stanway Hackett: Method for producing influenza hemagglutinin multivalent vaccines using baculovirus. MG PMC, Thomas J Kowalski, Curtis Morris & Safford PC, June 9, 1998: US05762939 (82 worldwide citation)

A method of preparing a recombinant influenza vaccine using DNA technology is provided. The resulting vaccine is a trivalent influenza vaccine based on a mixture of recombinant hemagglutinin antigens cloned from influenza viruses having epidemic potential. The recombinant hemagglutinin antigens are ...


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Gale Eugene Smith, James DeBartolomeis, Andrei Igorevitch Voznesenski: Insect cells or fractions as adjuvant for antigens. Protein Science, Thomas J Kowalski, Frommer Lawrence & Haug, May 1, 2001: US06224882 (13 worldwide citation)

Disclosed and claimed is an adjuvant for immunogenic, immunological, antigenic or vaccine compositions. The adjuvant is composed of insect cells or fractions thereof. Disclosed and claimed are also methods for preparing and using the adjuvant and compositions containing the adjuvant. Advantageously, ...


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Gale Eugene Smith, James T Matthews, Edwin D Kilbourne, Bert E Johansson, Bethanie E Wilkinson, Andrei I Voznesensky, Craig S Hackett, Franklin Volvovitz: Neuraminidase-supplemented compositions. Frommer Lawrence & Haug, September 4, 2003: US20030165521-A1

An anti-influenza vaccine composition wherein the improvement is that the vaccine includes, as an additive, neuraminidase (NA). The base anti-influenza vaccine can be any commercially available anti-influenza vaccine. The composition can include and be administered with an adjuvant. The vaccine comp ...


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Gale Eugene Smith, Bethanie E Wilkinson, Andrei I Voznesensky, Franklin Volvovitz, Craig S Hackett: Virus vaccines. Frommer Lawrence & Haug, June 13, 2002: US20020071848-A1

Improved mammalian virus vaccines are combinations that contain an immunogenic amount of inactivated virus, such as influenza virus, Herpes varicella virus, measles virus, Epstein Barr virus, respiratory syncytial virus, parainfluenza 3, Herpes simplex type 1 virus, and Herpes simplex type 2 virus, ...


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