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Kevin Rodzinak
Furuyama Hidetomo, Goto Yasuhiro, Kawanishi Nobuhiko, Layton Mark E, Mita Takashi, Naya Akira, Ogino Yoshio, Onozaki Yu, Rodzinak Kevin J, Sakamoto Toshihiro, Sanderson Philip E, Wang Jiabing: Inhibitors of akt activity. Merck & Co, Banyu Pharmaceutical, Furuyama Hidetomo, Goto Yasuhiro, Kawanishi Nobuhiko, Layton Mark E, Mita Takashi, Naya Akira, Ogino Yoshio, Onozaki Yu, Rodzinak Kevin J, Sakamoto Toshihiro, Sanderson Philip E, Wang Jiabing, Leff Matthew A, December 10, 2009: WO/2009/148916 (10 worldwide citation)

The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms, preferably Akt1. The invention also provides for compositions comprising such inhibitory compounds and methods ...


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Sakamoto Toshihiro, Sunami Satoshi, Yamamoto Fuyuki, Niiyama Kenji, Bamba Makoto, Takahashi Keiji, Furuyama Hidetomo, Sagara Takeshi, Otsuki Sachie, Nishibata Toshihide, Yoshizumi Takashi, Hirai Hiroshi: Dihydropyrazolopyrimidinone derivatives. Banyu Pharmaceutical, Sakamoto Toshihiro, Sunami Satoshi, Yamamoto Fuyuki, Niiyama Kenji, Bamba Makoto, Takahashi Keiji, Furuyama Hidetomo, Sagara Takeshi, Otsuki Sachie, Nishibata Toshihide, Yoshizumi Takashi, Hirai Hiroshi, Banyu Pharmaceutical, November 8, 2007: WO/2007/126122 (11 worldwide citation)

The invention relates to compounds of a general formula (I): wherein A1 is selected from the following formula (aa1); R1 is a lower alkenyl group or a lower alkynyl group; R2 is a phenyl, pyridyl or thienyl group; R5 and R6 are a hydrogen atom, a lower alkyl group or a hydroxy-lower alkyl group, etc ...


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Bamba Makoto, Furuyama Hidetomo, Niiyama Kenji, Sakamoto Toshihiro, Sunami Satoshi, Takahashi Keiji, Yamamoto Fuyuki, Yoshizumi Takashi: (Ja) ビシクロアニリン誘導体, (En) Bicycloaniline derivative. Banyu Pharmaceutical, Bamba Makoto, Furuyama Hidetomo, Niiyama Kenji, Sakamoto Toshihiro, Sunami Satoshi, Takahashi Keiji, Yamamoto Fuyuki, Yoshizumi Takashi, BANYU PHARMACEUTICAL, December 18, 2008: WO/2008/153207 (11 worldwide citation)

(EN) Disclosed are: a compound represented by the general formula (I); and others. (I) wherein A1 and A2 independently represent a nitrogen atom or a methine group which may be substituted; the ring B represents a 5- to 7-membered aliphatic ring or a spiro or bicyclo ring formed by the aliphatic rin ...


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Furuyama Hidetomo, Goto Yasuhiro, Kawanishi Nobuhiko, Layton Mark E, Mita Takashi, Ogino Yoshio, Onozaki Yu, Rossi Michael A, Sakamoto Toshihiro, Sanderson Philip E, Wang Jiabing: Inhibitors of akt activity. Merck & Co, Banyu Pharmaceutical, Furuyama Hidetomo, Goto Yasuhiro, Kawanishi Nobuhiko, Layton Mark E, Mita Takashi, Ogino Yoshio, Onozaki Yu, Rossi Michael A, Sakamoto Toshihiro, Sanderson Philip E, Wang Jiabing, Merck & Co, December 10, 2009: WO/2009/148887 (8 worldwide citation)

The instant invention provides for substituted [1,2,4]triazolo[4,3-a]-1,5-naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms, preferably Akt1. The invention also provides for compositions comprising such inhibi ...


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BAMBA MAKOTO, FURUYAMA HIDETOMO, NIIYAMA KENJI, SAKAMOTO TOSHIHIRO, SUNAMI SATOSHI, TAKAHASHI KEIJI, YAMAMOTO FUYUKI, YOSHIZUMI TAKASHI: [fr] DÉRIVÉ DANILINE BICYCLIQUE, [de] BICYCLOANILINDERIVAT, [en] BICYCLOANILINE DERIVATIVE. BANYU PHARMA, March 31, 2010: EP2168966-A1 (3 worldwide citation)

[en] The invention relates to a compound of a general formula (I): wherein A 1 and A 2 each mean a nitrogen atom or an optionally-substituted methine group Ring B means a 5-membered to 7-membered aliphatic ring, or a spiro or bicyclo ring formed from the aliphatic ring and any other 3-membered to 7- ...


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