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Nishimura Osamu, Fujino Masahiko: Chemically modified lymphokine and production thereof.. Takeda Chemical Industries, September 11, 1985: EP0154316-A2 (337 worldwide citation)

The invention provides chemically modified lymphokines having R &lparstr& O-CH2CH2 &rparstr& n wherein R is a protective group for the terminal oxygen and n is an optional positive integer, bonded directly to at least one primary amino group of the lymphokine moiety, and a method of producing the sa ...


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Fujino Masahiko, Kobayashi Shigeru, Obayashi Mikihiko, Shinagawa Susumu, Fukuda Tsunehiko: Novel nonapeptide amide analogs of luteinizing hormone releasing factor. Takeda Chemical, Wenderoth Lind & Ponack, December 10, 1974: US3853837 (36 worldwide citation)

The present invention relates to nonapeptide amide derivatives of the formula:L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-A.sub.1 -glycyl-A.sub.2 -L-arginyl-L-prolyl-Y(wherein A.sub.1 is L-tyrosyl or L-phenylalanyl; A.sub.2 is L-leucyl, L-isoleucyl, L-norleucyl, L-valyl, L-norvalyl, L-methionyl o ...


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Minami Isao, Ueno Hayao, Fujino Masahiko: Glycosyl derivatives and use thereof.. Takeda Chemical Industries, January 7, 1988: EP0251304-A2 (21 worldwide citation)

The invention provides a compound of the formula (I): R-O @CH2CH2O@ @@CH2)n-Z wherein R is a glycosyl group, m is an optional positive integer, n is an integer of 1 to 3 and Z is -CHO, -CH2OH or -COOH. The compound of the formula (I'): R-O @CH2CH2O @@@CH2)n-CHO wherein R, m and n are as defined abov ...


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Matsuzawa Tai, Hirai Shin ichiro, Fujino Masahiko, Kobayashi Shigeru, Yamazaki Iwao: Takeda Chemical, Wenderoth Lind & Ponack, November 4, 1975: US3917825 (18 worldwide citation)

Novel preparations essentially comprising nona- or deca-peptide having luteinizing hormone-releasing activity dispersed homogeneously in an oleaginous base or in a mixture of the oleaginous base and a non-ionic surfactant effectively exhibit a luteinizing hormone-releasing activity when administered ...


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Fujino Masahiko, Wakimasu Mitsuhiro, Nakajima Nobuo, Aoki Hisashi: L-aspartyl-aminomalonic acid diester. Takeda Chemical, Wenderoth Lind & Ponack, September 23, 1975: US3907766 (17 worldwide citation)

A novel dipeptide, L-aspartyl-aminomalonic acid alkyl fenchyl diester, and its physiologically acceptable salts which are useful as a sweetener, and production thereof and sweetening compositions containing the dipeptide ester or its salt.


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Miyake Akio, Kondo Masahiro, Fujino Masahiko: Antibacterial compounds, their production and use.. Takeda Chemical Industries, December 3, 1986: EP0203271-A2 (14 worldwide citation)

A compound of the formula; wherein R is an amino group which may be protected, R is a hydrogen atom or an optionally substituted hydrocarbon residue; Z is S, S -> O, O or CH2, R is a hydrogen atom, methoxy group or formamido group, R is a hydrogen atom, methyl group, hydroxyl group or halogen atom a ...


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Masaki Tomoh, Yanagisawa Masashi, Kurihara Hiroki, Onda Haruo, Itoh Yasuaki, Fujino Masahiko: Dna coding for endothelin and use thereof.. Takeda Chemical Industries, May 10, 1989: EP0315118-A2 (12 worldwide citation)

(1) a DNA sequence containing a DNA segment coding for porcine or human endothelin, (2) a precursor protein of porcine or human endothelin, (3) a transformant bearing a DNA sequence containing a DNA segment coding for percine or human endothelin, and (4) a method for preparing mature porcine or huma ...


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Miyake Akio, Kondo Masahiro, Fujino Masahiko: Antibacterial compounds.. Takeda Chemical Industries, November 6, 1985: EP0160252-A2 (9 worldwide citation)

A compound of the formula; wherein R stands for hydrogen atom, nitrogen-containing heterocyclic group, acyl group or esterified carboxyl group, Z stands for S, S->-O, O or CH2, R stands for hydrogen atom, methoxy group or formamido group, R stands for hydrogen atom, methyl group, hydroxyl group or h ...


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