1
Fu Xiaoyong, Thiruvengadam Tiruvettipuram K, Tann Chou Hong, Lee Junning, Colon Cesar: Process for preparing delta 9,11 and 21-chloro corticosteroids. Schering, March 19, 1997: EP0763054-A1 (10 worldwide citation)

Described is a process for the regioselective dehydration of 11-hydroxy steroids using PCl5, PCl3, POCl3 or either SO2Cl2 and imidazole, or PPh3 and CCl4. The disclosed process selectively forms DELTA 9,11 steroids from either 11- alpha - or 11- beta -hydroxy steroids, and can also be used for the o ...


2
Hu Mengwei, Yu Younong, Dwyer Michael, Taveras Arthur G, Kim Meade Agnes, Yin Jianguo, Fu Xiaoyong, Mcallister Timothy, Zhang Shuyi, Klopfer Kevin: Crystalline polymorphs of a cxc-chemokine receptor ligand. Schering Corporation, Hu Mengwei, Yu Younong, Dwyer Michael, Taveras Arthur G, Kim Meade Agnes, Yin Jianguo, Fu Xiaoyong, Mcallister Timothy, Zhang Shuyi, Klopfer Kevin, REINHARDT Gerard E, August 18, 2005: WO/2005/075447 (9 worldwide citation)

The present invention relates to four distinct crystalline polymorphs of a monohydrate of Compound A having the following chemical structure (A). These four polymorphic forms, herein referred to as Forms I, II, III and IV are active as a CXC-chemokine receptor ligands. The invention is further direc ...


3
Fu Xiaoyong, Thiruvengadam Tiruvettipuram K, Tann Chou Hong, Lee Junning, Colon Cesar: Process for preparing delta 9,11 and 21-chloro corticosteroids. Schering, January 5, 2000: EP0969011-A2 (7 worldwide citation)

Described is a process for the regioselective dehydration of 11-hydroxy steroids using PCl5, PCl3, POCl3 or either SO2Cl2 and imidazole, or PPh3 and CCl4. The disclosed process selectively forms DELTA steroids from either 11- alpha - or 11- beta -hydroxy steroids, and can also be used for the one-st ...


4
Fu Xiaoyong, Guenter Frank Bruno, Kim Meade Agnes S, Matthews Kenneth Stanley, Maust Mathew Thomas, Mcallister Timothy L, Werne Gerald, Winters Jason L, Yin Jianguo, Zhang Shuyi: Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds. Schering Corporation, Fu Xiaoyong, Guenter Frank Bruno, Kim Meade Agnes S, Matthews Kenneth Stanley, Maust Mathew Thomas, Mcallister Timothy L, Werne Gerald, Winters Jason L, Yin Jianguo, Zhang Shuyi, FISCHER H Eric, January 8, 2009: WO/2009/005801 (6 worldwide citation)

This application discloses a novel process for the preparation of 1.2 - substituted 3, 4 - dioxo - 1 - cyclobutene compounds of formula (A), which have utility, for example, in the treatment of CXC chemokine -mediated diseases, and intermediates useful in the synthesis thereof.


5

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Yin Jianguo, Fu Xiaoyong, Zhang Shuyi, Mcallister Timothy L, Kim Meade Agnes S, Winters Jason L, Sudhakar Anantha, Schumacher Doris P: Synthesis of 2-hydroxy-n,n-dimethyl-3-[[2-[1(r)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide. Schering Corporation, Yin Jianguo, Fu Xiaoyong, Zhang Shuyi, Mcallister Timothy L, Kim Meade Agnes S, Winters Jason L, Sudhakar Anantha, Schumacher Doris P, JEANETTE Henry C, November 4, 2004: WO/2004/094398 (2 worldwide citation)

Disclosed is a process for making the compound of formula (I), using the compounds of formulas (II), (Q), and (XI) or (XII) (II), wherein A is selected from the group consisting of Br, Cl and (I) (with Br being preferred); and R represents (C1-C10)alkyl. Also disclosed are intermediate compounds tha ...


7
Thiruvengadam Tiruvettipuram K, Wang Tao, Liao Jing, Chiu John S, Tsai David J S, Lee Hong Chang, Wu Wenxue, Fu Xiaoyong: Synthesis of himbacine analogs. Schering Corporation, Thiruvengadam Tiruvettipuram K, Wang Tao, Liao Jing, Chiu John S, Tsai David J S, Lee Hong Chang, Wu Wenxue, Fu Xiaoyong, REINHARDT Gerard E, July 20, 2006: WO/2006/076564 (2 worldwide citation)

The present invention relates to an improved process for preparing imbacine analogs. The compounds are useful as thrombin receptor antagonists. The improved process may allow for at least one of easier purification by crystallization, easier scalability, and improved process yield on the desired ena ...


8
Chen Frank Xing, Cutarelli Timothy D, Fu Xiaoyong, Liang Xian, Mcallister Timothy L, Orr Robert K, Yin Jianguo, Yong Kelvin H, Zhu Man: Process and intermediates for the synthesis of heterocyclic substituted piperazines with cxcr3 antagonist activity. Schering Corporation, Chen Frank Xing, Cutarelli Timothy D, Fu Xiaoyong, Liang Xian, Mcallister Timothy L, Orr Robert K, Yin Jianguo, Yong Kelvin H, Zhu Man, FISCHER H Eric, June 25, 2009: WO/2009/079490 (2 worldwide citation)

The present invention relates to novel processes for the preparation of the compound of the Formula A45: [Chemical formula should be inserted here as it appears in the paper abstract.] or a physiologically acceptable salt, solvate or prodrug thereof, which has utility, for example, as a pharmaceutic ...


9
Thiruvengadam Tiruvettipuram K, Fu Xiaoyong, Tann Chou Hong, Mcallister Timothy L, Chiu John S, Colon Cesar: Process for the synthesis of azetidinones. Schering, October 4, 2001: EP1137634-A1 (1 worldwide citation)

This invention provides a process for preparing the hypocholesterolemic compound (I) comprising: (a) reacting p-fluorobenzoylbutyric acid with pivaloyl chloride and acylating the product with a chiral auxiliary to obtain a ketone of formula (IV); (b) reducing the ketone of formula (IV) in the presen ...


10
Fu Xiaoyong, Thiruvengadam Tiruvettipuram K, Tann Chou Hong, Lee Junning, Colon Cesar: Process for preparing delta 9,11 and 21-chloro corticosteroids. Schering, January 5, 2000: EP0969012-A2

Described is a process for the regioselective dehydration of 11-hydroxy steroids using PCl5, PCl3, POCl3 or either SO2Cl2 and imidazole, or PPh3 and CCl4. The disclosed process selectively forms DELTA steroids from either 11- alpha - or 11- beta -hydroxy steroids, and can also be used for the one-st ...