1
Nico P Ghilardi, Frederic J de Sauvage, Audrey Goddard, Paul J Godowski, J Christopher Grimaldi, Austin Gurney, William I Wood: Nucleic acid encoding novel type-1 cytokine receptor GLM-R. Genentech, Craig G Svoboda, December 4, 2007: US07303896 (23 worldwide citation)

The present invention is directed to novel polypeptides and variants thereof of GLM-R polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypep ...


2
Frederic J de Sauvage, Iqbal Grewal, Austin L Gurney: Modulation of T cell differentiation for the treatment of T helper cell mediated diseases. Genentech, Morrison & Foerster, July 1, 2008: US07393532 (6 worldwide citation)

The present invention relates to methods for the treatment and diagnosis of immune related diseases, including those mediated by cytokines released primarily either Th1 or Th2 cells in response to antigenic stimulation. The present invention further relates to methods for biasing the differentiation ...


3
Frederic J de Sauvage, Arnon Rosenthal, Donna M Stone: Vertebrate smoothened proteins. Genentech, Craig G Svoboda, November 23, 1999: US05990281 (6 worldwide citation)

Novel vertebrate homologues of Smoothened, including human and rat Smoothened, are provided. Compositions including vertebrate Smoothened chimeras, nucleic acid encoding vertebrate Smoothened, and antibodies to vertebrate Smoothened, are also provided.


4
Jo Anne Hongo, Wesley Chang, Frederic J de Sauvage, Dan L Eaton, Allen J Ebens Jr, Gretchen D Frantz, Hartmut Koeppen, Andrew Polson, Victoria Smith: Compositions and methods for the treatment of tumor of hematopoietic origin. Genentech, Arnold & Porter, Bonny Yeung, Jeffery P Bernhardt, December 28, 2010: US07858330 (6 worldwide citation)

The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.


5
Wesley Chang, Frederic J de Sauvage, Dan L Eaton, Allen J Ebens Jr, Gretchen Frantz, Jo Anne S Hongo, Hartmut Koeppen, Andrew Polson, Victoria Smith: Compositions and methods for the treatment of tumor of hematopoietic origin. Genentech, Arnold & Porter, Bonny Yeung, Jeffrey P Bernhardt, February 15, 2011: US07888478 (6 worldwide citation)

The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.


6
Frederic J de Sauvage, Robert D Klein, Heidi S Phillips, Arnon Rosenthal: Polynucleotides encoding GFRα3. Genentech, James A Fox, Ginger R Dreger, Heller Ehrman, April 11, 2006: US07026138 (6 worldwide citation)

The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, and immunoadhesions and antibodies to mammalian GFRα3, a novel α-subunit receptor of the GDNF (i.e. GFR) receptor family. It furth ...


7
Frederic J de Sauvage, Robert D Klein, Heidi S Phillips, Arnon Rosenthal: GFRα3 polypeptides. Genentech, Jennifer L Elliott, James A Fox, Ginger R Dreger, April 6, 2010: US07691973 (4 worldwide citation)

The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, and immunoadhesions and antibodies to mammalian GFRα3, a novel α-subunit receptor of the GDNF (i.e. GFR) receptor family. It furth ...


8
Dan L Eaton, Frederic J de Sauvage: Hybridization and amplification of nucleic acids encoding mpl ligand. Genentech, Daryl B Winter, November 3, 1998: US05830647 (4 worldwide citation)

Isolated mpl ligand, isolated DNA encoding mpl ligand, and recombinant methods of preparing mpl ligand are disclosed. These mpl ligands are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocyte progenitor cells. Accordingly, these compounds are us ...


9
Frederic J de Sauvage, Arnon Rosenthal, Donna M Stone: Antibodies to vertebrate smoothened proteins. Genentech, Craig G Svoboda, October 24, 2000: US06136958 (3 worldwide citation)

Novel vertebrate homologues of Smoothened, including human and rat Smoothened, are provided. Compositions including vertebrate Smoothened chimeras, nucleic acid encoding vertebrate Smoothened, and antibodies to vertebrate Smoothened, are also provided.


10
Frederic J de Sauvage, Gretchen Frantz, Charles Montgomery, Franklin Peale, Zheng Zheng Shi, Mary Jean Sparks: Gene disruptions, compositions and methods relating thereto. Genentech, Bonny Yeung, Christopher De Vry, Ginger R Dreger, April 26, 2011: US07931902 (3 worldwide citation)

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, ...