1
Barry L Karger, Frantisek Foret, Paul M Zavracky, E Nicol McGruer, Qifeng Xue, Yuriy M Dunayevskiy: Microscale fluid handling system. Northeastern University, Weingarten Schurgin Gagnebin & Hayes, February 16, 1999: US05872010 (323 worldwide citation)

A microscale fluid handling system that permits the efficient transfer of nanoliter to picoliter quantities of a fluid sample from the spatially concentrated environment of a microfabricated chip to "off-chip" analytical or collection devices for further off-chip sample manipulation and analysis is ...


2
Barry L Karger, Frantisek Foret, Jan Preisler: On-line liquid sample deposition interface for matrix assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectroscopy. Northeastern University, Weingarten Schurgin Gagnebin & Hayes, January 16, 2001: US06175112 (38 worldwide citation)

A universal interface for continuous on-line liquid sample introduction directly to the time-of-flight mass spectrometer, which can further promote throughput and utility of MALDI-TOF MS, is disclosed. Preferably, the liquid sample includes a matrix, either solid or liquid, for use in matrix-assiste ...


3
Barry L Karger, William G Thilly, Frantisek Foret, Konstaintin Khrapko, Phouthone Koehavong, Aharon S Cohen, Roger W Giese: Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices. Massachusetts Institute of Technology, Northeastern University, Hamilton Brook Smith & Reynolds P C, May 27, 1997: US05633129 (23 worldwide citation)

The disclosure relates to a method for resolving double-stranded DNA species differing by at least one base pair. Each of the species is characterized by an iso-melting domain with a unique melting temperature contiguous with a melting domain of higher thermal stability.


4
Frantisek Foret, Thomas Rejtar, Bailin Zhang, Barry L Karger: Parallel sample loading and injection device for multichannel microfluidic devices. Northeastern University, Weingarten Schurgin Gagnebin & Lebovici, September 6, 2005: US06939452 (23 worldwide citation)

A sample load and injection device (10) includes sample introduction capillaries (11) attached to a microfluidic device (12). Sample introduction capillaries (11) are connected to sample introduction channels (18). Sample introduction capillaries (18) are connected to separation channels (20) at con ...


5
Barry L Karger, Frantisek Foret, Daniel P Kirby: Subatmospheric, variable pressure sample delivery chamber for electrospray ionization/mass spectrometry and other applications. Northeastern University, Weingarten Schurgin Gagnebin & Hayes, May 30, 2000: US06068749 (21 worldwide citation)

A subatmospheric, variable pressure sample delivery chamber, useful as an electrospray ionization device for introducing a sample into a mass spectrometer or as a sample delivery device for delivery of a sample to a collection device at subatmospheric pressures, is disclosed. The sample delivery cha ...


6
Barry L Karger, Dieter Schmalzing, Frantisek Foret: Siloxandediol coating for capillary electrophoresis and for general surface modification. Northeastern University, Weingarten Schurgin Gagnebin & Hayes, June 21, 1994: US05322608 (15 worldwide citation)

A coated microcapillary column for high performance electrophoresis is disclosed. A preferred microcapillary includes a column; a universal sub-layer of coating material that has been highly crosslinked using a crosslinking agent and attached covalently or non-covalently to the column wall; and a va ...


7
Barry L Karger, Lev Kotler, Frantisek Foret, Marek Minarik, Karel Kleparnik: Multichannel microscale system for high throughput preparative separation with comprehensive collection and analysis. Beckman Coulter, William H May, D David Hill, Weingarten Schurgin Gagnebin & Lebovici, December 9, 2003: US06660149 (14 worldwide citation)

A modular multiple lane or capillary electrophoresis (chromatography) system that permits automated parallel separation and comprehensive collection of all fractions from samples in all lanes or columns, with the option of further on-line automated sample fraction analysis, is disclosed. Preferably, ...


8
Barry L Karger, Frantisek Foret, Odilo M uller: Precise capillary electrophoretic interface for sample collection or analysis. Northeastern University, Weingarten Schurgin Gagnebin & Hayes, November 5, 1996: US05571398 (11 worldwide citation)

A capillary electrophoretic system and method for accurate and precise post-column manipulation of molecules separated by capillary electrophoresis is disclosed. The system of the invention includes a separation capillary; a detector positioned close to, and preferably less than approximately one cm ...


9
Barry L Karger, Frantisek Foret, Jan Preisler: On-line and off-line deposition of liquid samples for matrix assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectroscopy. Northeastern University, Weingarten Schurgin Gagnebin & Lebovici, November 30, 2004: US06825463 (10 worldwide citation)

A universal interface for continuous on-line liquid sample introduction directly to the time-of-flight mass spectrometer, which can further promote throughput and utility of MALDI-TOF MS, is disclosed. Preferably, the liquid sample includes a matrix, either solid or liquid, for use in matrix-assiste ...


10
Barry L Karger, Frantisek Foret, Jan Preisler: On-line and off-line deposition of liquid samples for matrix assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectroscopy. Northeastern University, Weingarten Schurgin Gagnebin & Lebovici, January 6, 2004: US06674070 (9 worldwide citation)

A universal interface for continuous on-line liquid sample introduction directly to the time-of-flight mass spectrometer, which can further promote throughput and utility of MALDI-TOF MS, is disclosed. Preferably, the liquid sample includes a matrix, either solid or liquid, for use in matrix-assiste ...