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Gale E Smith, Franklin Volvovitz, Bethanie E Wilkinson, Andrei I Voznesensky, Craig S Hackett: Vaccine comprising a baculovirus produced influenza hemagglutinin protein fused to a second protein. Protein Sciences Corporation, Thomas J Kowalski, Frommer Lawrence & Haug, January 12, 1999: US05858368 (85 worldwide citation)

A method of preparing a recombinant influenza vaccine using DNA technology is provided. The resulting vaccine is a multivalent, preferably trivalent, influenza vaccine based on a mixture of recombinant hemagglutinin antigens cloned from influenza viruses having epidemic potential. The recombinant he ...


2
Gale Eugene Smith, Franklin Volvovitz, Bethanie Eident Wilkinson, Craig Stanway Hackett: Method for producing influenza hemagglutinin multivalent vaccines using baculovirus. MG PMC, Thomas J Kowalski, Curtis Morris & Safford PC, June 9, 1998: US05762939 (84 worldwide citation)

A method of preparing a recombinant influenza vaccine using DNA technology is provided. The resulting vaccine is a trivalent influenza vaccine based on a mixture of recombinant hemagglutinin antigens cloned from influenza viruses having epidemic potential. The recombinant hemagglutinin antigens are ...


3
Gale E Smith, Franklin Volvovitz, Bethanie E Wilkinson, Andrei I Voznesensky, Craig S Hackett: Method for producing influenza hemagglutinin multivalent vaccines. Protein Sciences Corporation, Thomas J Kowalski, Frommer Lawrence & Haug, June 12, 2001: US06245532 (24 worldwide citation)

A method of preparing a recombinant influenza vaccine using DNA technology is provided. The resulting vaccine is a multivalent, preferably trivalent, influenza vaccine based on a mixture of recombinant hemagglutinin antigens cloned from influenza viruses having epidemic potential. The recombinant he ...


4
Franklin Volvovitz: Virus vaccines. Protein Sciences Corporation, Thomas J Kowalski, Frommer Lawrence & Haug, November 2, 1999: US05976552 (15 worldwide citation)

Improved mammalian virus vaccines are combinations that contain an immunogenic amount of inactivated virus, such as influenza virus, Herpes varicella virus, measles virus, Epstein Barr virus, respiratory syncytial virus, parainfluenza 3, Herpes simplex type 1 virus, and Herpes simplex type 2 virus, ...


5
Gail Eugene Smith, James T Matthews, Edwin D Kilbourne, Bert E Johansson, Bethanie E Wilkinson, Andrei I Voznesensky, Craig S Hackett, Franklin Volvovitz: Neuraminidase-supplemented compositions. Protein Sciences Corporation, William S Frommer, Thomas J Kowalski, Frommer Lawrence & Haug, November 26, 2002: US06485729 (11 worldwide citation)

An anti-influenza vaccine composition wherein the improvement is that the vaccine includes, as an additive, neuraminidase (NA). The base anti-influenza vaccine can be any commercially available anti-influenza vaccine. The composition can include and be administered with an adjuvant. The vaccine comp ...


6
Gail Eugene Smith, James T Matthews, Edwin D Kilbourne, Bert E Johansson, Bethanie E Wilkinson, Andrie I Voznesensky, Craig S Hackett, Franklin Volvovitz: Methods of making neuraminidase-supplemented compositions. Protein Sciences Corporation, Frommer Lawrence & Haug, Thomas J Kowalski, Angela M Collison, October 4, 2005: US06951649 (4 worldwide citation)

The present invention relates to a method for formulating a vaccine composition which comprises an anti-influenza vaccine, wherein the improvement of the vaccine composition is that the vaccine includes, as an additive, neuraminidase (NA). The base anti-influenza vaccine can be any commercially avai ...


7
Franklin Volvovitz: Pharmaceutical compositions and methods for preventing, treating, or reversing neuronal dysfunction. Gary J Gershik, Cooper & Dunham, October 30, 2012: US08299062

The present invention provides compositions and methods for preventing, treating or reversing neuronal dysfunction in a mammal resulting from exposure to organophosphate nerve agents, organophosphate insecticides and incapacitating agents of the central nervous system (CNS); CNS injury, including tr ...


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Franklin Volvovitz, Gale E Smith, Mark A Cochran: Polypeptides derived from envelope gene of human immunodeficiency virus in recombinant baculovirus infected insect cells. Microgenesys, West Haven, Connecticut 06516, Usa, YANG JIUCHANG, December 21, 1988: CN87107837

The baculovirus-insect cell vector system is used as a high efficiency eukaryotic cloning and expression method for the production of recombinant proteins. A major application of this system is also in the development of rDNA vaccines for a variety of important human and animal diseases. This system ...


10
Franklin Volvovitz: Skin test and test kit for aids. Microgenesys, YANG JIUCHANG, June 20, 1990: CN89109558

A method for the detection of AIDS virus infection in humans involves the introduction of an effective amount of an immunogenic AIDS virus envelope protein intradermally into a human and the subsequent observation of the injection site for an immune response, such as a characteristic redness or swel ...



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