1
Frank W Hobbs Jr, Anthony J Cocuzza: Alkynylamino-nucleotides. E I Du Pont de Nemours and Company, George A Frank, September 10, 1991: US05047519 (259 worldwide citation)

Alkynylamino-nucleotides and labeled alkynylamino-nucleotides useful, for example, as chain terminating substrates for DNA sequencing are provided along with several key intermediates and processes for their preparation.


2
Frank W Hobbs Jr, George L Trainor: Alkynylamino-nucleotides. E I Du Pont de Nemours and Company, George A Frank, September 29, 1992: US05151507 (155 worldwide citation)

Alkynylamino-nucleotides and labeled alkynylaminonucleotides useful, for example, as chain terminating substrates for DNA sequencing are provided along with several key intermediates and processes for their preparation. For some applications, longer, hydrophilic linkers are provided.


3
James M Prober, Rudy J Dam, Charles W Robertson Jr, Frank W Hobbs Jr, George L Trainor: Method, system and reagents for DNA sequencing. E I Du Pont de Nemours and Company, July 26, 1994: US05332666 (147 worldwide citation)

A DNA sequencing system and method are described to detect the presence of radiant energy emitted from different excited reporter dye-labeled species (DNA fragments) following separation in time and/or space, and the identity of the species which emit radiant energy closely spaced in wavelength. Fun ...


4
Frank W Hobbs Jr: Reagents for the preparation of 5-tagged oligonucleotides. E I Du Pont de Nemours and Company, November 16, 1993: US05262536 (117 worldwide citation)

Fluorescent reagents possessing an activated phosphate for the convenient covalent coupling to the 5'-hydroxyl of oligonucleotides. A class of 5'-fluorescence-tagged oligonucleptides is also disclosed.


5
Frank W Hobbs Jr: Fluorescent reagents for the preparation of 5-tagged oligonucleotides. E I Du Pont de Nemours and Company, March 5, 1991: US04997928 (117 worldwide citation)

Fluorescent reagents possessing an activated phosphate for the convenient covalent coupling to the 5'-hydroxyl of oligonucleotides. A class of 5.dbd.-fluorescence-tagged oligonucleotides is also disclosed.


6
James M Prober, Rudy J Dam, Charles W Robertson Jr, Frank W Hobbs Jr, George L Trainor: Method, system and reagents for DNA sequencing. E I Du Pont de Nemours and Company, September 7, 1993: US05242796 (82 worldwide citation)

A DNA sequencing system and method are described to detect the presence of radiant energy emitted from different excited reporter dye-labeled species (DNA fragments) following separation in time and/or space, and the identity of the species which emit radiant energy closely spaced in wavelength. Fun ...


7
Anthony J Cocuzza, Frank W Hobbs Jr, Robert J Zagursky, Neil A Straus: Method for sequencing DNA using biotin-strepavidin conjugates to facilitate the purification of primer extension products. E I Du Pont de Nemours and Company, January 16, 1996: US05484701 (59 worldwide citation)

A simplified method for isolating primer extension products and generating them in a form appropriate for electrophoresis is disclosed. The method is compatible with automated DNA sequencing procedures.


8
James M Prober, Rudy J Dam, Charles W Robertson Jr, Frank W Hobbs Jr, George L Trainor: Method systems and reagents for DNA sequencing. E I Du Pont de Nemours and Company, April 26, 1994: US05306618 (55 worldwide citation)

A DNA sequencing system and method are described to detect the presence of radiant energy emitted from different excited reporter dye-labeled species (DNA fragments) following separation in time and/or space, and the identity of the species which emit radiant energy closely spaced in wavelength. Fun ...


9
Frank W Hobbs Jr, George L Trainor: Method, system and reagents for DNA sequencing. E I Du Pont de Nemours and Company, March 4, 1997: US05608063 (36 worldwide citation)

A DNA sequencing system and method are described to detect the presence of radiant energy emitted from different excited reporter dye-labeled species (DNA fragments) following separation in time and/or space, and the identity of the species which emit radiant energy closely spaced in wavelength. Fun ...