1
Woonza M Rhee, Frank A DeLustro, Richard A Berg: Crosslinked polymer compositions and methods for their use. Cohesion Technologies, Laurie A Axford, Foley & Lardner, April 18, 2000: US06051648 (500 worldwide citation)

Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has bee ...


2
Woonza M Rhee, Richard A Berg, George H Chu, Frank A DeLustro, Dan M Jolivette, Kimberly A McCullough: Injectable or implantable biomaterials for filling or blocking lumens and voids of the body. Collagen Corporation, Morrison & Foerster, May 19, 1998: US05752974 (490 worldwide citation)

Methods for completely or partially blocking, augmenting, sealing, or filling various biological lumens and voids within the body of a patient are disclosed. Lumens include arteries, veins, intestines, Fallopian tubes, and trachea. Voids include various lesions, fissures, diverticulae, cysts, fistul ...


3
Woonza M Rhee, Frank A DeLustro, Richard A Berg: Crosslinked polymer compositions and methods for their use. Cohesion Technologies, Fish & Richardson P C, February 23, 1999: US05874500 (345 worldwide citation)

Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has bee ...


4
Woonza M Rhee, Frank A DeLustro, Richard A Berg: Method of using crosslinked polymer compositions in tissue treatment applications. Cohesion Technologies, Morrison & Foester, December 26, 2000: US06166130 (247 worldwide citation)

Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has bee ...


5
Olof Mikael Trollsas, Donald G Wallace, Frank A DeLustro: Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use. Cohesion Technologies, Dianne E Reed, Reed & Associates, October 1, 2002: US06458889 (180 worldwide citation)

Crosslinkable compositions are provided that readily crosslink in situ to provide biocompatible, nonimmunogenic crosslinked biomaterials. The compositions contain at least three biocompatible, nonimmunogenic components having reactive functional groups thereon, with the functional groups selected so ...


6
Louis C Sehl, Olof Mikael Trollsas, Donald G Wallace, David Toman, Frank A DeLustro, Jacqueline A Schroeder, George H Chu: Methods for tissue repair using adhesive materials. Cohesion Technologies, Dianne E Reed, Mark L Warzel, Reed Intellectual Property Law Group, December 21, 2004: US06833408 (158 worldwide citation)

A method of tissue repair is provided using a biocompatible nonimmunogenic adhesive composition. The adhesive composition comprises collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction betwe ...


7
Jeffrey E Yeung, George H Chu, Frank A DeLustro, Woonza M Rhee: Anti-adhesion films and compositions for medical use. Collagen Corporation, Laurie A Axford, Shirley L Church, Wilhelmus J Wytenburg, December 3, 1996: US05580923 (157 worldwide citation)

Anti-adhesion films useful for the prevention of surgical adhesions are disclosed. These films comprise substrate materials (such as collagen) and hetero-bifunctional anti-adhesion binding agents, wherein the substrate material is covalently linked to receptive tissue within the body of a patient vi ...


8
Woonza M Rhee, Prema R Rao, George H Chu, Frank A DeLustro, Carol F H Harner, Naomi Sakai, Jacqueline A Schroeder: Collagen-based bioadhesive compositions. Collagen Corporation, Kathi Rafayko, March 25, 1997: US05614587 (155 worldwide citation)

Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. A particularly preferred composition comprise ...


9
Woonza M Rhee, Frank A DeLustro, Richard A Berg: Method of making crosslinked polymer matrices in tissue treatment applications. Cohesion Technologies, Laurie A Axford, Dianne E Reed, November 27, 2001: US06323278 (102 worldwide citation)

Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has bee ...


10
Woonza M Rhee, Prema R Rao, George H Chu, Frank A DeLustro: Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications. Collagen Corporation, Kathi Rafayko, Shirley L Church, October 15, 1996: US05565519 (102 worldwide citation)

Various forms of chemically modified collagen are covalently crosslinked with activated synthetic hydrophilic polymers to form optically clear biocompatible conjugates useful in a variety of medical applications, particularly in ophthalmic devices. The chemically modified collagen is in substantiall ...