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Elbert Chin, Javier de Vicente Fidalgo, Jim Li, Alfred Sui Ting Lui, Kristen Lynn McCaleb, Ryan Craig Schoenfeld, Francisco Xavier Talamas: Heterocyclic antiviral compounds. Roche Palo Alto, Brian L Buckwalter, April 17, 2012: US08158631 (11 worldwide citation)

Compounds having the formula I wherein R1, R2, R3, R4, and R5 are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.


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Leyi Gong, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm: Cyclic amine derivatives-CCR-3 receptor antagonists. Syntex, Robert C Hall, January 10, 2006: US06984637 (5 worldwide citation)

This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.


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Sharada Shenvi Labadie, Clara Jeou Jen Lin, Francisco Xavier Talamas, Robert James Weikert: Heterocyclic antiviral compounds. Roche Palo Alto, Brian L Buckwalter, December 6, 2011: US08071797 (4 worldwide citation)

Compounds having the formula I wherein R1, R2, R3, R4, R5 and X are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.


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Lars G J Hammarström, Nancy Elisabth Krauss, Sharada Shenvi Labadie, David Bernard Smith, Francisco Xavier Talamas: Synthesis of purine derivatives. Roche Palo Alto, Grant D Green, September 12, 2006: US07105666 (4 worldwide citation)

The present invention provides a method for producing 2-, 6-, 8- and 9-substituted purine compounds from 4,6-dihalo-5-nitro-2-alkyl-pyrimidine compounds in solution or by solid phase techniques. The present process provides for the sequential introduction of amine substituents at the 4- and 6-positi ...