1
Jeffrey R Churchill, Francis G Hutchinson: Continuous release formulations. Imperial Chemical, Cushman Darby & Cushman, July 2, 1985: US04526938 (304 worldwide citation)

Pharmaceutical compositions comprising a pharmacologically active polypeptide and a pharmacologically or veterinarily acceptable amphipathic, non-cross-linked linear, branched or graft block copolymer, which has a minimum weight average molecular weight of 5,000, in which the hydrophobic component i ...


2
Francis G Hutchinson: Continuous release pharmaceutical compositions. Imperial Chemical, Cushman Darby & Cushman, August 30, 1988: US04767628 (247 worldwide citation)

Pharmaceutical compositions, comprising a polylactide and a pharmacologically active, acid stable polypeptide, which when placed in an aqueous physiological environment release the polypeptide at an approximately constant rate in an essentially monophasic manner, with a minimal, or no induction peri ...


3
Jeffrey R Churchill, Francis G Hutchinson: Biodegradable amphipathic copolymers. Imperial Chemical, Cushman Darby & Cushman, May 17, 1988: US04745160 (137 worldwide citation)

A pharmaceutically or veterinarily acceptable amphipathic, non-cross linked linear, branched or graft block copolymer, which has a minimum weight average molecular-weight of 1000, in which the hydrophobic component is biodegradable or hydrolytically unstable under normal physiological conditions, an ...


4
Jeffrey R Churchill, Francis G Hutchinson: Continuous release formulations. Imperial Chemical, Cushman Darby & Cushman, July 17, 1990: US04942035 (66 worldwide citation)

Pharmaceutical compositions comprising a pharmacologically active polypeptide and a pharmacologically or veterinarily acceptable amphipathic, non-cross-linked linear, branched or graft block copolymer, which has a minimum weight average molecular weight of 5,000, in which the hydrophobic component i ...


5
Francis G Hutchinson: Continuous release pharmaceutical compositions. Zeneca, Cushman Darby & Cushman, November 22, 1994: US05366734 (56 worldwide citation)

Pharmaceutical compositions, comprising a polylactide and a pharmacologically active, acid stable polypeptide, which when placed in an aqueous physiological environment release the polypeptide at an approximately constant rate in an essentially monophasic manner, with a minimal, or no induction peri ...


6
Francis G Hutchinson: Continuous release pharmaceutical compositions formed by freeze drying acetic acid solutions of polylactide. Imperial Chemical, Cushman Darby & Cushman, April 2, 1991: US05004602 (55 worldwide citation)

Pharmaceutical compositions, comprising a polylactide and a pharmacologically active, acid stable polypeptide, which when placed in an aqueous physiological equipment release the polypeptide at an approximately constant rate in an essentially monophasic manner, with a minimal, or no induction period ...


7
Francis G Hutchinson: Manufacture of polyesters. Imperial Chemical, Cushman Darby & Cushman, December 6, 1988: US04789726 (52 worldwide citation)

A process for the manufacture of polyesters, especially polylactides or poly(lactide-co-glycolide) of specified low-medium molecular weight, by controlled hydrolysis of a higher molecular weight polyester.


8
Francis J T Fildes, Francis G Hutchinson: Delivery means for biologically active agents. Imperial Chemical, Cushman Darby & Cushman, November 25, 1980: US04235988 (51 worldwide citation)

A sustained release delivery means comprising a biologically active agent and a hydrophilic linear block poly oxyalkylene- polyurethane copolymer.


9
Francis J T Fildes, Francis G Hutchinson: Delivery means for biologically active agents comprising hydrophilic polyurethane. Imperial Chemical, Cushman Darby & Cushman, May 13, 1980: US04202880 (31 worldwide citation)

Sustained release delivery means comprising (i) a biologically active agent, (ii) a linear hydrophilic block polyoxyalkylene-polyurethane copolymer, and (iii) optionally containing a buffer. Included among the biologically active agents are abortifacient compounds.


10
Jeffrey R Churchill, Francis G Hutchinson: Biodegradable amphipathic copolymers. Imperial Chemical, Cushman Darby & Cushman, October 31, 1989: US04877606 (4 worldwide citation)

A pharmaceutically or veterinarily acceptable amphipathic, non-cross linked linear, branched or graft block copolymer, which has a minimum weight average molecular-weight of 1000, in which the hydrophobic component is biodegradable or hydrolytically unstable under normal physiological conditions, an ...