1
Kosley Raymond W Jr, Flanagan Denise M, Martin Lawrence Leo, Nemoto Peter Allen: (amino)Acetamides and related (1h-indol-1-yl)-(aminoalkyl)amides, intermediates and a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, October 6, 1993: EP0563916-A1 (4 worldwide citation)

There are disclosed compounds having the formula wherein X is hydrogen, chloro, bromo, fluoro, hydroxy, loweralkoxy, arylloweralkoxy, acyloxy, loweralkylaminocarbonyloxy, diloweralkylaminocarbonyloxy, amino, loweralkylamino, diloweralkylamino, acylamino, loweralkyl or trifluoromethyl; Y is hydrogen, ...


2
Flanagan Denise M: Alpha-oxopyrrolo[2,3-b]indole acetic acids, esters, amides and related analogs, a process for their preparation and their use as medicaments.. Hoechst Roussel Pharma, November 21, 1991: EP0457318-A1 (2 worldwide citation)

This invention relates to compounds of the formula where X is -NH, oxygen, N-loweralkyl, or N-arylloweralkyl; R1 is hydrogen, loweralkyl, cycloalkyl, aryl, arylloweralkyl, loweralkylene, haloloweralkyl, heteroaryl selected from the group consisting of thienyl, furanyl, pyrrolyl and pyridinyl; hetero ...


3
Allen Richard C, Flanagan Denise M: Pyrrolo, not 2,3-b indole-ketones and analogs, a process for their preparation and their use as medicaments. Hoechst Roussel Pharma, November 13, 1991: EP0456196-A1 (1 worldwide citation)

This invention relates to pyrrolo[2,3-b]indole ketones of the formula where R1 is loweralkyl, aryl or arylloweralkyl; R2 is hydrogen, halogen or loweralkyl; R3 is hydrogen or loweralkyl; R4 is loweralkyl or arylloweralkyl; R5 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, arylloweralkyl, formy ...


4
Martin Lawrence Leo, Flanagan Denise M, Payack Joseph Francis: 2-(4-piperidinyl)-1h-pyrido[4,3-b]indol-1 ones and related compounds, intermediates and a process for their preparation.. Hoechst Roussel Pharma, April 22, 1992: EP0481254-A2

The present application relates to novel 2-(4-piperidinyl)-1H-pyrido[4,3-b]indol-1-ones of formula wherein R is hydrogen, optionally substituted phenyl or phenylalkyl, R is hydrogen, alkyl, furanylalkyl, thienylalkyl, pyrrolylalkyl, pyridinylalkyl, optionally substituted phenylalkyl or a group of fo ...


5
Allen Richard C, Flanagan Denise M: Indole-cetones et analogues, procede de preparation et utilisation comme medicaments, Pyrrolo�2,3-b, Indole-ketones and analogs, a process for their preparation and their use as medicaments, Pyrrolo�2,3-b. Hoechst Roussel Pharmaceuticals, Aventis Pharmaceuticals, BERESKIN & PARR, December 4, 2001: CA2042327

This invention relates to pyrrolo[2,3-b]indole ketones of the formulasee formula I where R1 is loweralkyl, aryl or arylloweralkyl; R2 is hydrogen, halogen or loweralkyl; R3is hydrogen or loweralkyl; R4 is loweralkyl or arylloweralkyl; R5 is hydrogen, loweralkyl,loweralkenyl, loweralkynyl, aryllowera ...


6
Martin Lawrence Leo, Flanagan Denise M, Payack Joseph Francis: Indol-1-ones et composes apparentes, intermediaires et procede dobtention, 2-(4-piperidinyl)-1h-pyrido �4,3-b, Indol-1-ones and related compounds, intermediates and a process for their preparation, 2-(4-piperidinyl)-1h-pyrido�4,3-b. Hoechst Roussel Pharmaceuticals, Aventis Pharmaceuticals, BERESKIN & PARR, December 25, 2001: CA2052424

The present invention relates to novel 2-(4-piperidinyl)-1H-pyrido[4,3-b]indol-1-ones and related compounds, intermediates and processes for the preparingthereof. In particular, the present invention provides compounds of formula 1(see formula I)wherein R1 is hydrogen, loweralkyl, phenyl, phenyl sub ...


7
Martin Lawrence L, Kosley Raymond W Jr, Flanagan Denise M, Kuerzel Gert U, Nemoto Peter A, Wettlaufer David G: 1-aminoacetamidopyrrole and 1-amino-acetamido-2-(substituted)-pyrrole and related compound. Hoechst Roussel Pharmaceut, July 5, 1994: JP1994-184097

PURPOSE: To obtain the new compounds including 1-aminoacetamidopyrrole derivatives which are useful as glycine partial agonists and for the enhancement of learning and memory and for the treatment of memory dysfunctions associated with neurodegenerative disorders and are thus for the treatment of Al ...


8
Flanagan Denise M, Martin Lawrence L: 4-amno-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidine-2-ones and carbamate derivative of 1-amino-1-cyclopropanecarboxylic acid analog. Hoechst Roussel Pharmaceut, August 3, 1993: JP1993-194519

PURPOSE: To prepare a compd. useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease. CONSTITUTION: A compd. of the formula R1NH-COOR2 [R1 is formula I to III; R2 is formulae IV to VI; R3 is OR12 NH2 or mono or di lower alkyl; R4, R5 and ...


9
Kosley Raymond W Jr, Flanagan Denise M, Martin Lawrence L, Nemoto Peter A: (amino)Acetamide, related (1-indol-1-yl)-(aminoalkyl)amide, intermediate, their production and their use as medicine. Hoechst Roussel Pharmaceut, February 15, 1994: JP1994-041069

PURPOSE: To produce the new compd. useful as neuroprotective agents. CONSTITUTION: This compd. is expressed by formula I [X is H, Cl, Br, F, OH, (aryl) lower alkoxy or the like; Y is H, lower alkyl, Cl or Br; Z is H, lower alkyl, lower alkoxy, halogen or the like; R1 is H, (aryl) lower alkyl or the ...


10
Martin Lawrence L, Kosley Jr Raymond W, Flanagan Denise M, Kuerze Gert Ulrich, Nemoto Peter A, Wettlaufe David A: (substituted) Pyrrole and related compound and pharmaceutical composition containing the same. Hoechst Roussel Pharmaceuticals Incorporated, August 27, 2001: KR1019930014659

PURPOSE: An 1-aminoacetamidopyrrole, an 1-amino-2-(substituted)pyrrole, a related compounds and a pharmaceutical composition containing the same are provided to be useful for the enhancement of learning and memory and for the treatment of memory dysfunctions associated with neurodegenerative disorde ...