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Doherty James B, Finke Paul E, Firestone Raymond A, Hagmann William K, Shah Shrenik K, Thompson Kevan R: New substituted cephalosporin sulfones as antiinflammatory and antidegenerative agents, pharmaceutical compositions containing the same and processes for making them.. Merck & Co, November 7, 1984: EP0124081-A2 (19 worldwide citation)

New substituted cephalosporin sulfones are disclosed having the structural formula: wherein M is, e.g., trifluoromethyl, chloro or fluoro or -COOH; R1 is, e.g., hydrogen, hydroxy, mercapto, substituted oxy, substituted thio, hydrocarbyl or substituted hydrocarbyl group; B is OB1, or NB2B3 wherein B1 ...


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Firestone Raymond A: Lysosomotropic fluorinated amine therapeutic agents and compositions containing them.. Merck & Co, April 16, 1980: EP0009944-A2 (16 worldwide citation)

Compositions useful in the control of fertility, the inhibition of malignant cell growth, and the control of other diseases which accumulate macrophages at the disease site, comprising a pharmaceutical carrier and lysosomotropic substance comprising a weakly basic amine of pK 4.5 to 9 containing at ...


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Doherty James B, Finke Paul E, Firestone Raymond A, Hagmann William K, Thompson Kevan R, Shah Shrenik K: New substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents.. Merck & Co, May 18, 1988: EP0267723-A2 (15 worldwide citation)

New substituted cephalosporin sulfones with structural formula: are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.


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Firestone Raymond A: Lysosomotropic detergent therapeutic agents, compositions containing them and their uses.. Merck & Co, January 20, 1982: EP0044090-A2 (11 worldwide citation)

Compounds of formula: M-N=A in which M is a peptide substituent comprising z-gly-phe, gly-phe, z-arg-arg, or benzoyl-arg, and A or N=A is an active lysosome-inhibiting substance comprising a known therapeutic drug residue or an amino radical of the formula: in which R is an alkyl or substituted alky ...


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Firestone Raymond A: Derivatives of steroid compounds linked to cyotoxic agents and process for their preparation.. Merck & Co, April 18, 1984: EP0105404-A1 (6 worldwide citation)

The present application is concerned with compounds useful as carriers of cytotoxic agents. More particularly it deals with derivatives of steroid compounds having a 5-androstene carbon skeleton and having an oleyl ester at the 3-position and having a 17-carbamyl alkyl substituent which linked to cy ...


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Firestone Raymond A: A method for the preparation of (cis-1,2-epoxypropyl)phosphonic acid derivatives. Merck & Co, July 25, 1972: US3679712 (5 worldwide citation)

A method for the preparation of (.+-.) and (-) (cis-1,2-epoxypropyl)phosphonic acid and its salt, amide and ester derivatives via the reaction of a 2-oxy substituted n-propylphosphonate or diamide analog with a reagent capable of effecting ring closure. The (.+-.) and (-) (cis-1,2-epoxypropyl)phosph ...


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Christensen Burton G, Firestone Raymond A, Johnston David B R: Process to prepare intermediates for the preparation of cephalosporins and penicillins. Merck & Co, Pfeiffer Hesna J, Behan J Jerome, April 1, 1975: US3875146 (4 worldwide citation)

A process is provided which yields derivatives of cephalosporins and penicillins. The process starts with 7-aminodecephalosporanic acid or 6-APA and reacts with a carbonyl containing compound to form a Schiff's base (imino) adduct. This latter compound is then treated with a defined reagent yielding ...



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