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James Doherty
Dorn Conrad P, Finke Paul E, Maccoss Malcolm, Doherty James B, Shah Shrenik K, Hagmann William K: New substituted azetidinones as anti-inflammatory and antidegenerative agents.. Merck & Co, April 22, 1992: EP0481671-A1 (40 worldwide citation)

New substituted azetidinones of the general formula (A') which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described. e


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Doherty James B, Finke Paul E, Firestone Raymond A, Hagmann William K, Shah Shrenik K, Thompson Kevan R: New substituted cephalosporin sulfones as antiinflammatory and antidegenerative agents, pharmaceutical compositions containing the same and processes for making them.. Merck & Co, November 7, 1984: EP0124081-A2 (19 worldwide citation)

New substituted cephalosporin sulfones are disclosed having the structural formula: wherein M is, e.g., trifluoromethyl, chloro or fluoro or -COOH; R1 is, e.g., hydrogen, hydroxy, mercapto, substituted oxy, substituted thio, hydrocarbyl or substituted hydrocarbyl group; B is OB1, or NB2B3 wherein B1 ...


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Doherty James B, Finke Paul E, Firestone Raymond A, Hagmann William K, Thompson Kevan R, Shah Shrenik K: New substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents.. Merck & Co, May 18, 1988: EP0267723-A2 (15 worldwide citation)

New substituted cephalosporin sulfones with structural formula: are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.


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Davies Philip, Doherty James B, Finke Paul E, Humes John L, Leudke Edward S, Maccoss Malcolm, Mumford Richard A, Shah Shrenik K: Substituted azetidinones useful in the treatment of leukemia. Merck & Co, November 3, 1993: GB2266527-A (12 worldwide citation)

Compounds of formula I and salts thereof, wherein R is C1-6alkyl; R is C1-6alkyl or C1-6alkoxy-C1-6alkyl; and M, X5, X6, X7 and X8 are hydrogen or specific substituents, are useful in the treatment of leukemia.


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Hanlon William A, Mumford Richard A, Humes John L, Maccoss Malcolm, Knight Wilson B, Finke Paul E, Hagmann William K, Shah Shrenik K: Assay for evaluating inhibition of pmn elastase by n-substituted azetidinones.. Merck & Co, March 3, 1993: EP0529719-A1 (10 worldwide citation)

N-substituted azetidinones are a class of inhibitors of human leukocytes elastase which are known to be useful in the treatment of a wide variety of antiinflammatory and antidegenerative diseases. In inhibiting elastase, the therapeutic agents are shown to form a characteristic stable complex with t ...


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Thompson Kevan R, Finke Paul E, Doherty James B: Penicillin derivatives as anti-inflammatory and antidegenerative agents.. Merck & Co, February 5, 1986: EP0170192-A1 (7 worldwide citation)

Derivatives of Penicillin, their sulfoxides and sulfones of the structural formula: wherein q is 0, 1 or 2; A is, e.g., CH3 or CH2O(CO)CH3; R1 is, e.g., R min NRa wherein Ra is H or C1-6alkyl and R min is, e.g., hydrogen or R - (CH2)n -@- where R represents: (i) hydrogen; (ii) C1-6alkyl; (iii) trifl ...


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Davies Philip, Doherty James B, Finke Paul E, Humes John L, Luedke Edward S, Maccoss Malcolm, Mumford Richard A, Shah Shrenik K: Substituted cephalosporin sulfone compositions useful in the treatment of leukemia. Merck & Co, November 3, 1993: GB2266525-A (6 worldwide citation)

Pharmaceutical compositions containing a compound of formula I wherein the symbols are as defined in the specification; and epsilon-aminocaproic acid, heparin, trasylol, prednisolone, cytosine arabinoside, 6-mercaptopurine, cytarabine, an anthracycline or a vitamin A derivative, may be used in the t ...


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Finke Paul E, Kissinger Amy L, Maccoss Malcolm, Shah Shrenik K, Doherty James B, Hagmann William K, Davies Philip, Humes John L, Luedke Edward S, Mumford Richard A: Substituted azetidinones as anti-inflammatory and antidegenerative agents.. Merck & Co, February 3, 1993: EP0525973-A2 (3 worldwide citation)

New substituted azetidinones of the general formula (I) which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described.



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