James DohertyNew substituted azetidinones are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
James DohertyNew substituted azetidinones of the general formula (A') which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described. e
New substituted cephalosporin sulfones are disclosed having the structural formula: wherein M is, e.g., trifluoromethyl, chloro or fluoro or -COOH; R1 is, e.g., hydrogen, hydroxy, mercapto, substituted oxy, substituted thio, hydrocarbyl or substituted hydrocarbyl group; B is OB1, or NB2B3 wherein B1 ...
New substituted cephalosporin sulfones with structural formula: are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
Compounds of formula I and salts thereof, wherein R is C1-6alkyl; R is C1-6alkyl or C1-6alkoxy-C1-6alkyl; and M, X5, X6, X7 and X8 are hydrogen or specific substituents, are useful in the treatment of leukemia.
N-substituted azetidinones are a class of inhibitors of human leukocytes elastase which are known to be useful in the treatment of a wide variety of antiinflammatory and antidegenerative diseases. In inhibiting elastase, the therapeutic agents are shown to form a characteristic stable complex with t ...
Derivatives of Penicillin, their sulfoxides and sulfones of the structural formula: wherein q is 0, 1 or 2; A is, e.g., CH3 or CH2O(CO)CH3; R1 is, e.g., R min NRa wherein Ra is H or C1-6alkyl and R min is, e.g., hydrogen or R - (CH2)n -@- where R represents: (i) hydrogen; (ii) C1-6alkyl; (iii) trifl ...
Pharmaceutical compositions containing a compound of formula I wherein the symbols are as defined in the specification; and epsilon-aminocaproic acid, heparin, trasylol, prednisolone, cytosine arabinoside, 6-mercaptopurine, cytarabine, an anthracycline or a vitamin A derivative, may be used in the t ...
New substituted azetidinones of the general formula (I) which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described.
