1
Michael J Heller, Eugene Tu: Active programmable electronic devices for molecular biological analysis and diagnostics. Nanogen, Lyon & Lyon, February 25, 1997: US05605662 (640 worldwide citation)

A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, antibody/antigen reaction, diagnostics, and biop ...


2
Michael J Heller, Eugene Tu, William F Butler: Molecular biological diagnostic systems including electrodes. Nanogen, Lyon & Lyon, May 27, 1997: US05632957 (508 worldwide citation)

A system for performing molecular biological diagnosis, analysis and multi-step and multiplex reactions utilizes a self-addressable, self-assembling microelectronic system for actively carrying out controlled reactions in microscopic formats. These reactions include most molecular biological procedu ...


3
Ronald G Sosnowski, William F Butler, Eugene Tu, Michael I Nerenberg, Michael J Heller, Carl F Edman: Methods and procedures for molecular biological analysis and diagnostics. Nanogen, Lyon & Lyon, April 18, 2000: US06051380 (249 worldwide citation)

A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridizations, antibody/antigen reactions, diagnostics, and bi ...


4
Michael J Heller, Eugene Tu: Methods for electronic synthesis of polymers. Nanogen, Lyon & Lyon, July 27, 1999: US05929208 (126 worldwide citation)

A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, antibody/antigen reaction, diagnostics, and biop ...


5
Michael J Heller, Eugene Tu, Ronald G Sosnowski, James P O Connell: Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis. Nanogen, Lyon & Lyon, April 11, 2000: US06048690 (118 worldwide citation)

Methods for electronic perturbation of fluorescence, chemilluminescence and other emissive materials provide for molecular biological analysis. In a preferred method for hybridization analysis of a sample, an electronic stringency control device is used to perform the steps of: providing the sample, ...


6
Mark M Wang, Eugene Tu, James P O&apos Connell, Kristie L Lykstad, William F Butler: Method for separation of particles. Genoptix, O&apos Melveny & Myers, November 9, 2004: US06815664 (74 worldwide citation)

Apparatus and methods are provided for interacting light with particles, including but not limited to biological matter such as cells, in unique and highly useful ways. Optophoresis consists of subjecting particles to various optical forces, especially optical gradient forces, and more particularly ...


7
Michael J Heller, Eugene Tu: Deoxyribonucleic acid(DNA) optical storage using non-radiative energy transfer between a donor group, an acceptor group and a quencher group. Nanogen, Lyon & Lyon, July 28, 1998: US05787032 (74 worldwide citation)

An optical memory system includes memory cells which utilize synthetic DNA as a component of the information storage mechanism. In the preferred embodiment, memory cells contain one or more chromophoric memory units attached to a support substrate. Each chromophoric memory unit comprises a donor, an ...


8
Carl F Edman, Eugene Tu, Christian Gurtner, Lorelei Westin, Michael J Heller: Electronic systems and component devices for macroscopic and microscopic molecular biological reactions, analyses and diagnostics. Nanogen, O&apos Melveny & Myers, August 24, 2004: US06780584 (65 worldwide citation)

This invention pertains to the design, fabrication, and uses of an electronic system which can actively carry out and control multi-step and multiplex reactions in macroscopic or microscopic formats. In particular, these reactions include molecular biological reactions, such as nucleic acid hybridiz ...


9
Mark M Wang, Eugene Tu, James P O&apos Connell, Kristie L Lykstad, William F Butler: Method for sorting particles. Genoptix, O&apos Melveny & Myers, December 21, 2004: US06833542 (52 worldwide citation)

A method for sorting a particle of interest from a plurality of particles includes the steps of determining an absorption maxima of the particle of interest, providing a light source for generating a beam of coherent light at a wavelength correlating to the absorption maxima, providing a plurality o ...


10
Mark M Wang, Eugene Tu, James P O&apos Connell, Kristie L Lykstad, William F Butler: Methods of separating particles using an optical gradient. Genoptix, O&apos Melveny & Myers, June 1, 2004: US06744038 (51 worldwide citation)

Apparatus and methods are provided for interacting light with particles, including but not limited to biological matter such as cells, in unique and highly useful ways. Optophoresis consists of subjecting particles to various optical forces, especially optical gradient forces, and more particularly ...



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