1
Eugene Bell: Bone-equivalent and method for preparation thereof. Massachusetts Institute of Technology, Arthur A Smith Jr, David E Brook, November 27, 1984: US04485097 (222 worldwide citation)

A bone-equivalent, useful in the fabrication of prostheses, is disclosed which is prepared from a hydrated collagen lattice contracted by fibroblast cells and containing demineralized bone powder.


2
Eugene Bell: Tissue-equivalent and method for preparation thereof. Massachusetts Institute of Technology, Arthur A Smith Jr, David E Brook, November 27, 1984: US04485096 (189 worldwide citation)

A tissue-equivalent, useful in the treatment of burns or other skin wounds and in the fabrication of prostheses, is disclosed which is prepared from a hydrated collagen lattice contracted by a contractile agent, such as fibroblast cells or blood platelets, to form tissue-equivalent. In one embodimen ...


3
Eugene Bell, Tracy M Sioussat, Timothy W Fofonoff: Biopolymer foams for use in tissue repair and reconstruction. Tissue Engineering, Thomas V Smurzynski, Lahive & Cockfield, April 6, 1999: US05891558 (186 worldwide citation)

Single and double density biopolymer foams, composite biopolymer foams including both single and double density foams, and methods of preparing these foams and composite foams are described. Also described are biocompatible constructs which include single or double density biopolymer foams and extra ...


4
Eugene Bell, Tracy M Sioussat, Michael J Begley: Biopolymer matt for use in tissue repair and reconstruction. Tissue Engineering, Lahive & Cockfield, January 30, 2001: US06179872 (153 worldwide citation)

Biopolymer matt, biopolymer matt composites, biopolymer matt compositions, and methods of preparing the matt and composite matts are described. Also described are biocompatible constructs which include extracellular matrix macromolecules and methods of preparing these constructs. The matt, matt comp ...


5
Eugene Bell, Tracy M Sioussat, Timothy W Fofonoff: Biopolymer foams for use in tissue repair and reconstruction. Tissue Engineering, Lahive & Cockfield, November 28, 2000: US06153292 (126 worldwide citation)

Single and double density biopolymer foams, composite biopolymer foams including both single and double density foams, and methods of preparing these foams and composite foams are described. Also described are biocompatible constructs which include single or double density biopolymer foams and extra ...


6
Eugene Bell: Method and construct for producing graft tissue from an extracellular matrix. Tissue Engineering, Lahive & Cockfield, September 1, 1998: US05800537 (114 worldwide citation)

Using animal tissues as starting materials, a method is described for producing extracellular matrix particulates. The invention includes an embodiment wherein the matrix particulates are applied to collagen scaffolds, which can be seeded with living cells or the particulates may alone be seeded wit ...


7
Eugene Bell: Fabrication of living blood vessels and glandular tissues. Massachusetts Institute of Technology, Arthur A Smith Jr, David E Brook, Leo R Reynolds, October 15, 1985: US04546500 (110 worldwide citation)

A method and apparatus for producing a vessel-equivalent prosthesis is described. A contractile agent such as fibroblast cells, smooth muscle cells or platelets is incorporated into a collagen lattice and contracts the lattice axially around an inner core. After the structure has set, additional lay ...


8
Eugene Bell: Fabrication of living blood vessels and glandular tissues. Massachusetts Institute of Technology, David E Brook, Leo R Reynolds, Smith Jr Arthur A, September 10, 1985: US04539716 (92 worldwide citation)

A method and apparatus for producing a vessel-equivalent prosthesis is described. A contractile agent such as fibroblast cells, smooth muscle cells or platelets is incorporated into a collagen lattice and contracts the lattice axially around an inner core. After the structure has set, additional lay ...


9
Eugene Bell, Timothy W Fofonoff: Methods for preparing biopolymer foams. Tissue Engineering, Thomas V Smurzynski, Lahive & Cockfield, September 7, 1999: US05948429 (81 worldwide citation)

A biopolymer solution is polymerized to form a gel which is freeze-dried and crosslinked with ultraviolet radiation to form a biopolymer foam. The foam is filled with a collagen solution and the combination is freeze-dried or the foam is filled with a collagen solution containing extracellular matri ...


10
Eugene Bell, Crispin Weinberg: Tissue equivalent test systems. David G Conlin, Linda M Buckley, May 30, 1989: US04835102 (73 worldwide citation)

The present invention provides methods of, apparatus for, and kits for determining the interaction of tissue and at least one agent by use of at least one tissue equivalent. Tissue equivalent includes, but is not limited to, equivalents of epithelial tissue, connective tissue, cartilage, bone, blood ...