1
Roy A Whitehead, Mark S Chagnon, Ernest V Groman, Lee Josephson: Magnetic particles for use in separations. Advanced Magnetics, Pennie & Edmonds, November 19, 1985: US04554088 (245 worldwide citation)

A process is provided for the preparation of magnetic particles to which a wide variety of molecules may be coupled. The magnetic particles can be dispersed in aqueous media without rapid settling and conveniently reclaimed from media with a magnetic field. Preferred particles do not become magnetic ...


2
Mark S Chagnon, Ernest V Groman, Lee Josephson, Roy A Whitehead: Binding assays employing magnetic particles. Advanced Magnetics, Pennie & Edmonds, December 9, 1986: US04628037 (126 worldwide citation)

A process is provided for the preparation of magnetic particles to which a wide variety of molecules may be coupled. The magnetic particles can be dispersed in aqueous media without rapid settling and conveniently reclaimed from media with a magnetic field. Preferred particles do not become magnetic ...


3
Ernest V Groman, Lee Josephson: Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents. Advanced Magnetics Incorporated, Pennie & Edmonds, September 13, 1988: US04770183 (116 worldwide citation)

This invention relates to an improved method for obtaining the in vivo MNR image of an organ or tissue of an animal or human subject. More specifically, this invention relates to the use of small (about 10 to about 5,000 angstroms in diameter) biodegradable superparamagnetic metal oxide particles fo ...


4
Mark S Chagnon, Ernest V Groman, Lee Josephson, Roy A Whitehead: Magnetic particles for use in separations. Advanced Magnetics, Pennie & Edmonds, September 22, 1987: US04695393 (103 worldwide citation)

A process is provided for the preparation of magnetic particles to which a wide variety of molecules may be coupled. The magnetic particles can be dispersed in aqueous media without rapid settling and conveniently reclaimed from media with a magnetic field. Preferred particles do not become magnetic ...


5
Ernest V Groman, Lee Josephson, Jerome M Lewis: Biologically degradable superparamagnetic materials for use in clinical applications. Advanced Magnetics Incorporated, Pennie and Edmonds, May 9, 1989: US04827945 (87 worldwide citation)

This invention relates to materials exhibiting certain magnetic and biological properties which make them uniquely suitable for use as magnetic resonance imaging (MRI) agents to enhance MR images of animal organs and tissues. More particularly, the invention relates to the in vivo use of biologicall ...


6
Roy A Whitehead, Mark S Chagnon, Ernest V Groman, Lee Josephson: Magnetic particles for use in separations. Advanced Magnetics, Pennie & Edmonds, September 22, 1987: US04695392 (78 worldwide citation)

A process is provided for the preparation of magnetic particles to which a wide variety of molecules may be coupled. The magnetic particles can be dispersed in aqueous media without rapid settling and conveniently reclaimed from media with a magnetic field. Preferred particles do not become magnetic ...


7
Roy A Whitehead, Mark S Chagnon, Ernest V Groman, Lee Josephson: Enzymatic reactions using magnetic particles. Advanced Magnetics, Pennie & Edmonds, October 6, 1987: US04698302 (68 worldwide citation)

A process is provided for the preparation of magnetic particles to which a wide variety of molecules may be coupled. The magnetic particles can be dispersed in aqueous media without rapid settling and conveniently reclaimed from media with a magnetic field. Preferred particles do not become magnetic ...


8
Lee Josephson, Edward T Menz, Ernest V Groman: Solvent mediated relaxation assay system. Advanced Magnetics, Bromberg & Sunstein, November 17, 1992: US05164297 (64 worldwide citation)

A new ligand binding assay is based upon measurements of relaxation rates of the solvent, which are obtained with a magnetic resonance (MR) spectrometer. It is termed a solvent mediated relaxation assay system (SMRAS). SMRAS is based on the observation that the enhancement of proton relaxation rates ...


9
Lee Josephson, Edward T Menz, Ernest V Groman: Solvent mediated relaxation assay system. Advanced Magnetics, Bromberg & Sunstein, October 19, 1993: US05254460 (58 worldwide citation)

A new ligand binding assay is based upon measurements of relaxation rates of the solvent, which are obtained with a magnetic resonance (MR) spectrometer. It is termed a solvent mediated relaxation assay system (SMRAS). SMRAS is based on the observation that the enhancement of proton relaxation rates ...


10
Jerome M Lewis, Edward T Menz, Francis E Kenny, Ernest V Groman, Lee Josephson: Vascular magnetic imaging method and agent comprising biodegradeable superparamagnetic metal oxides. Advanced Magnetics, Pennie & Edmonds, October 8, 1991: US05055288 (50 worldwide citation)

The preparation and isolation of biodegradable superparamagnetic MR imaging contrast agents for the vascular compartment is described. These aggregates are comprised of individual biodegradable superparamagnetic metal oxide crystals which aggregates have an overall mean diameter less than about 4000 ...