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Antonin Holy, Erik Desire Alice De Clercq: N.sup.6 - substituted nucleotide analagues and their use. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, November 2, 1999: US05977061 (103 worldwide citation)

Novel PMP, PME and HPMP and related compounds containing N-6 substituted 2,6-diaminopurine and adenine bases are provided. These compounds are useful in a variety of utilities, including as intermediates in the preparation of flame retardants, diagnostic reagents and therapeutics, including antivira ...


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Robert Walter Jansen, Dirk Klaas Fokke Meijer, Grietje Molema, Erik Desire Alice De Clercq, Rudi Wilfried Jan Pauwels, Dominique Schols: Modified proteins and their use for controlling viral infections. Rijksuniversiteit Te Groningen, Bachman & LaPointe P C, February 9, 1999: US05869457 (4 worldwide citation)

The invention relates to pharmaceutical preparations which are suitable for treating viral infections, including influenza and immunodeficiency diseases and which can also be used in vitro, to inhibit fusion of virus-infected cells with non-infected cells, which preparations contain modified protein ...


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Erik Desire Alice De Clercq, Piet Andre Maurits Herdewlin, Arthur Albert Edgard Van Aerschot: Method of using 1,5-anhydrohexitol nucleoside analogues to treat viral infections. Stichting Rega VZW, Webb Ziesenheim Bruening Logsdon Orkin & Hanson P C, September 16, 1997: US05668113 (1 worldwide citation)

It has been found that 1,5-anhydrohexitol nucleoside analogues, wherein a 4-substituted-2,3,4-trideoxy-1,5-anhydrohexitol is coupled via its 2-position to the heterocyclic ring of a pyrimidine or purine base, exhibit remarkable anti-viral properties against herpes viruses, pox viruses and related vi ...


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