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Robert M Straubinger, Amarnath Sharma, Eric Mayhew: Taxol formulation. The Research Foundation of State University of New York, Nixon Hargrave Devans & Doyle, May 16, 1995: US05415869 (92 worldwide citation)

The present invention relates to a pharmaceutical composition for use in treatment of cancer patients. The composition includes at least one taxane present in a pharmaceutical effective amount and a mixture of one or more negatively charged phospholipids and one or more zwitterion (i.e. uncharged) p ...


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Eric Mayhew, M Jane Ehrke, Kenneth Mace, Francis Szoka, Fred C Olson: Liposome drug delivery method and composition. Liposome Technology, Peter J Dehlinger, Hana Dolezalova, October 10, 1989: US04873088 (42 worldwide citation)

A method for enhancing the therapeutic effectiveness of adriamycin, in the treatment of cancer, is disclosed. Liposomes containing coentrapped adriamycin and a secondary compound effective to reduce the toxicity of adriamycin or enhance the induction by adriamycin of the tumoricidal activity of host ...


3
Yong Wei, Eric Mayhew, Imran Ahmad, Andrew S Janoff: Pharmaceutically active ceramide-related compounds. The Liposome Company, Kenneth B Rubin, May 20, 1997: US05631394 (35 worldwide citation)

This invention provides a compound having the formula R.sup.1 --Y.sup.1 --CHZ.sup.1 --CH(NY.sup.2 Y.sup.3)--CH.sub.2 --Z.sup.2, wherein: R.sup.1 is a straight-chained alkyl, alkenyl or alkynyl group having from 8 to 19 carbon atoms in the aliphatic chain; Y.sup.1 is --CH.dbd.CH--, --C.tbd.C-- or --C ...


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Eric Mayhew, J Craig Franklin, Suresh Bhatia, Paul A Harmon, Andrew S Janoff: Hydrophobic taxane derivatives. The Liposome Company, Kenneth B Rubin, December 3, 1996: US05580899 (24 worldwide citation)

This invention provides a taxane derivative of the formula: ##STR1## wherein a hydrophobic organic moiety is attached to a taxane. R and R.sup.1 is each indepently H or a hydrophobic organic moiety, as long as at least one of R and R.sup.1 is not H. Attachment of a hydrophobic organic moiety to the ...


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Yong Wei, Eric Mayhew, Imran Ahmad, Andrew S Janoff: Methods of treatment using pharmaceutically active ceramide-related compositions. The Liposome Company, Kenneth B Rubin, October 14, 1997: US05677337 (19 worldwide citation)

This invention provides a compound having the formula R.sup.1 --Y.sup.1 --CHZ.sup.1 --CH(NY.sup.2 Y.sup.3)--CH.sub.2 --Z.sup.2, wherein: R.sup.1 is a straight-chained alkyl, alkenyl or alkynyl group having from 8 to 19 carbon atoms in the aliphatic chain; Y.sup.1 is --CH.dbd.CH--, --C.tbd.C-- or --C ...


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Walter Perkins, Xingong Li, Donald Hirsh, Eric Mayhew, Imran Ahmad, Shaukat Ali, Andrew Janoff: Particulate formulations. The Liposome Company, Burns Doane Swecker & Mathis L, December 31, 2002: US06500461 (14 worldwide citation)

This invention provides vehicles capable of delivering high concentrations of poorly hydrophilic/poorly lipophilic compounds to animals, by combining compounds having biocompatible hydrophobic domains with conjugates having both hydrophobic and hydrophilic regions. Such formulations are suitable for ...


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Eric Mayhew, Andrew S Janoff, Imran Ahmad, Suresh K Bhatia: Etherlipid containing multiple lipid liposomes. The Liposome Company, Rosanne Goodman, August 24, 1999: US05942246 (9 worldwide citation)

Liposomes are provided which contain etherlipids having the formula: ##STR1## as well as an unsaturated or partially unsaturated phospholipid, a sterol, and a phosphatidylethanolamine-based headgroup-derivatized lipid. These liposomes are useful in a variety of therapeutic regimens, including the tr ...


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Shaukat Ali, J Craig Franklin, Imran Ahmad, Eric Mayhew, Soumendu Bhattacharya, Gil Koehane, Andrew S Janoff: Hydrolysis-promoting hydrophobic taxane derivatives. The Liposome Company, Burns Doane Swecker & Mathis L, November 19, 2002: US06482850 (8 worldwide citation)

Provided herein is a taxane having a hydrocarbon attached at the 2′ and/or 7 positions, the hydrocarbon's alpha position being occupied by a “hydrolysis-promoting group” (“HPG”). In one embodiment, the hydrolysis promoting group is stereospecifically attached to the &agr;-carbon of the hydropho ...


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Eric Mayhew, Andrew S Janoff, Imran Ahmad, Suresh K Bhatia: Multilipid component ether lipid liposomes. The Liposome Company, Kenneth B Rubin, June 9, 1998: US05762958 (6 worldwide citation)

Liposomes are provided which contain ether lipids having the formula: ##STR1## as well as an underivatized phosphatidylethanolamine, a sterol, and a phosphatidylethanolamine-dicarboxylic acid headgroup-derivatized lipid. These liposomes are useful in a variety of therapeutic regimens, including the ...


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