1
Jayati Ghosh, Bill J Peck, Eric M Leproust, Charles David Troup, Glenda Choate Delenstarr, Patrick J Collins, John F Corson, Paul K Wolber, Xiangyang Zhou: Method and system for quantifying and removing spatial-intensity trends in microarray data. Agilent Technologies, November 27, 2007: US07302348 (56 worldwide citation)

A method and system for quantifying and correcting spatial-intensity trends for each channel of a microarray data set having one or more channels. The method and system of one embodiment of the present invention selects a set of features from each channel of the microarray data set. Based on the sel ...


2
Robert Gellibolian, Eric M Leproust: Methods and compositions for high throughput identification of protein/nucleic acid binding pairs. Agilent Technologies, March 30, 2004: US06713262 (24 worldwide citation)

Methods and compositions for high-throughput identification of protein/nucleic acid binding pairs are provided. In the subject methods, a nucleic acid probe array, e.g., a molecular beacon probe array, is contacted with a target nucleic acid population to produce a hybridized array. The resultant hy ...


3
Paul K Wolber, Robert H Kincaid, Douglas Amorese, Diane Ilsley Tyree, Andrew S Atwell, Mel N Kronick, Eric M Leproust: Chemical arrays and methods of using the same. Agilent Technologies, September 15, 2009: US07588889 (14 worldwide citation)

Methods and compositions for generating mixtures of product molecules from an initial chemical array are provided. In the subject methods, a chemical array of surface immobilized first moieties is subjected to cleavage conditions such that a composition of solution phase first moieties is produced. ...


4
Jay K Bass, Maryam Mobed Miremadi, Eric M Leproust: Manufacture of arrays with reduced error impact. Agilent Technologies, Agilent Technologies, September 6, 2005: US06939673 (12 worldwide citation)

Methods and apparatus are disclosed for synthesizing a purality of compounds such as biopolymers on the surface of supports. The synthesis comprises a plurality of steps in which reagents for conducting the synthesis are deposited o the surface of the support to form precursors of the chemical compo ...


5
Mel N Kronick, Eric M Leproust: Chemical arrays and methods of using the same. Agilent Technologies, July 12, 2011: US07977119 (10 worldwide citation)

Methods and compositions for generating mixtures of product molecules from an initial chemical array are provided. In the subject methods, a chemical array of surface immobilized first moieties is subjected to cleavage conditions such that a composition of solution phase first moieties is produced. ...


6
Eric M Leproust, Lalitha Reddy, Michel G M Perbost: Method and apparatus for microarray fabrication. Agilent Technologies, July 24, 2007: US07247337 (10 worldwide citation)

The invention provides a method and apparatus for micro array fabrication exclusive from the impact of a gas. A housing with a gas free chamber provides for improved micro array fabrication with a lower defect rate. The invention provides a housing that excludes a gas such as ozone to prevent intera ...


7
Eric M Leproust: Apparatuses and methods for oligonucleotide preparation. Agilent Technologies, April 9, 2013: US08415138 (10 worldwide citation)

Provided are improved processes and apparatuses for solid phase oligonucleotide synthesis, the improvements comprising carrying out detritylation of the nascent oligonucleotide using a composition of an organic solvent, a protic solvent and a selected concentration, or selected concentration range, ...


8
Robert Gellibolian, Eric M Leproust: Methods and compositions for high throughput identification of protein/nucleic acid binding pairs. Agilent Technologies, March 20, 2007: US07192710 (10 worldwide citation)

Methods and compositions for high-throughput identification of protein/nucleic acid binding pairs are provided. In the subject methods, a nucleic acid probe array, e.g., a molecular beacon probe array, is contacted with a target nucleic acid population to produce a hybridized array. The resultant hy ...


9
Theodore R Sana, Eric M Leproust, Michel G M Perbost, Paul K Wolber: Nucleic acid array in situ fabrication methods and arrays produced using the same. Agilent Technologies, May 19, 2009: US07534561 (9 worldwide citation)

Methods and devices for producing a nucleic acid arrays using in situ nucleic acid array synthesis protocols are provided. A feature of certain embodiments of the invention is that control probes are produced in collections of features, e.g., columns, of the arrays that have been selected according ...


10
Theodore R Sana, Eric M Leproust, Paul K Wolber: Methods and apparatus for preparing arrays comprising features having degenerate biopolymers. Agilent Technologies, March 17, 2009: US07504213 (9 worldwide citation)

Methods and apparatus are disclosed for synthesizing a plurality of biopolymers at predetermined feature locations on a surface of a substrate. One or more of the feature locations comprises degenerate biopolymers. One or more biopolymer subunit precursors are added, in multiple rounds of subunit ad ...