1
Yoshikawa Seiji, Emori Eita, Matsuura Fumiyoshi, Clark Richard, Ikuta Hironori, Yasuda Nobuyuki, Nagakura Tadashi, Yamazaki Kazuto, Aoki Mika: Xanthine derivatives as dpp-iv inhibitors. Eisai, August 27, 2003: EP1338595-A2 (68 worldwide citation)

The present invention provides novel compounds exhibiting an excellent DPPIV inhibition effect. The compounds are represented by the formula: wherein, m is 0 or 1; n is 0; R, R, R, R, R, R, R, R, R, R, R, and R each represent a hydrogen atom; X represents an alkynyl group, an aryl group, and such, w ...


2
Yoshikawa Seiji, Emori Eita, Matsuura Fumiyoshi, Richard Clark, Ikuta Hironori, Kira Kazunobu, Yasuda Nobuyuki, Nagakura Tadashi, Yamazaki Kazuto: Novel fused imidazole derivative. Eisai, March 16, 2005: EP1514552-A1 (57 worldwide citation)

The present invention is related to compounds represented by the following formula, or salts or hydrates thereof wherein, T represents a 4- to 12-membered heterocyclic group containing one or two nitrogen atoms in the ring, which is a monocyclic or bicyclic structure that may have one or more substi ...


3
Shinoda Masanobu, Emori Eita, Matsuura Fumiyoshi, Kaneko Toshihiko, Ohi Norihito, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Miyashita Sadakazu, Hibara Taro, Seiki Takashi, Clark Richard, Harada Hitoshi: Carboxylic acid derivatives and drugs containing the same. Eisai, June 26, 2002: EP1216980-A1 (25 worldwide citation)

The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin-resistant improver, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the follow ...


4
Matsuura Fumiyoshi, Emori Eita, Shinoda Masanobu, Clark Richard, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Inoue Takashi, Miyashita Sadakazu, Hihara Taro, Harada Hitoshi, Ohashi Kaya: Carboxylic acid derivative and salt thereof. Eisai, January 14, 2004: EP1380562-A1 (14 worldwide citation)

The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin sensitizer, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the following form ...


5
Yoshikawa Seiji, Emori Eita, Matsuura Fumiyoshi, Richard Clark, Ikuta Hironori, Kira Kazunobu, Yasuda Nobuyuki, Nagakura Tadashi, Yamazaki Kazuto: Novel fused imidazole derivative. Eisai, Yoshikawa Seiji, Emori Eita, Matsuura Fumiyoshi, Richard Clark, Ikuta Hironori, Kira Kazunobu, Yasuda Nobuyuki, Nagakura Tadashi, Yamazaki Kazuto, SHIMIZU Hatsushi, December 18, 2003: WO/2003/104229 (5 worldwide citation)

A compound represented by the general formula (I) [wherein T1 means an optionally substituted, monocyclic or bicyclic, 4- to 12-membered, heterocyclic group containing one or two nitrogen atoms in the ring; X means optionally substituted C1-6 alkyl, etc.; Z1 and Z2 each independently means nitrogen ...


6
Matsuura Fumiyoshi, Emori Eita, Shinoda Masanobu, Clark Richard, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Inoue Takashi, Miyashita Sadakazu, Hihara Taro: Carboxylic acid derivative and medicine comprising salt or ester of the same. Eisai, March 3, 2004: EP1394147-A1 (2 worldwide citation)

The present invention provides novel carboxylic acid derivatives useful as an insulin sensitizer, a salt thereof or a hydrate of them, and a medicament comprising the derivative as the active ingredient. Specifically, it provides a carboxylic acid derivative represented by the following formula: (wh ...


7
Matsuura Fumiyoshi, Emori Eita, Shinoda Masanobu, Clark Richard, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Inoue Takashi, Miyashita Sadakazu, Hihara Taro: Benzene compound and salt thereof. Eisai, January 2, 2004: EP1375472-A1 (2 worldwide citation)

The present invention provides a medicament comprising a benzene compound useful as an insulin sensitizer, a salt thereof or a hydrate of them and a derivative of them as the active ingredient. Specifically, it provides a benzene compound represented by the following formula, a salt thereof or a hyd ...


8
Shinoda Masanobu, Emori Eita, Matsuura Fumiyoshi, Kaneko Toshihiko, Ohi Norihito, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Miyashita Sadakazu, Hibara Taro, Seiki Hisashi, Clark Richard, Harada Hitoshi: Carboxylic acid derivatives and drugs containing the same. Eisai, Shinoda Masanobu, Emori Eita, Matsuura Fumiyoshi, Kaneko Toshihiko, Ohi Norihito, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Miyashita Sadakazu, Hibara Taro, Seiki Hisashi, Clark Richard, Harada Hitoshi, FURUYA Kaoru, April 12, 2001: WO/2001/025181 (2 worldwide citation)

Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the derivatives as the active ingredient. In said formula, R?1¿ is hydrogen, hydroxyl, alkyl, or the like; L is a s ...


9
Clark Richard, Matsuura Fumiyoshi, Emori Eita, Shinoda Masanobu, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Inoue Takashi, Miyashita Sadakazu, Hihara Taro: Cyclic compound and ppar agonist. Eisai, September 1, 2004: EP1452521-A1 (1 worldwide citation)

The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. Wherein a, b and c are the same as or different from one another and each re ...


10
Matsuura Fumiyoshi, Emori Eita, Shinoda Masanobu, Clark Richard, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Inoue Takashi, Miyashita Sadakazu, Hihara Taro: Benzene compound and salt thereof. Eisai, Matsuura Fumiyoshi, Emori Eita, Shinoda Masanobu, Clark Richard, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Inoue Takashi, Miyashita Sadakazu, Hihara Taro, FURUYA Kaoru, October 17, 2002: WO/2002/081428 (1 worldwide citation)

A benzene compound represented by the following general formula (I), which is useful as an insulin-resistant ameliorant. (I) In the formula, X represents optionally substituted aryl or heteroaryl; Y represents a group represented by the general formula (II) (wherein R?Y1¿, R?Y2¿, and R?Y3¿ each repr ...