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Jan Steyaert, Toon Laeremans, Els Pardon: Chimeric polypeptides comprising G protein-coupled receptors and VHH antibodies. VIB VZW, Vrije Universiteit Brussel, TraskBritt P C, March 14, 2017: US09593157

Described are polypeptides and their use for screening and drug discovery. More specifically, the disclosure provides chimeric polypeptides comprising a membrane protein, in particular a GPCR, fused to a binding domain, wherein the binding domain is directed against and/or specifically binds to the ...


2
Jan Steyaert, Els Pardon, Soren Rasmussen, Juan Fung, Brian Kobilka, Toon Laeremans: Protein binding domains stabilizing functional conformational states of GPCRs and uses thereof. VIB VZW, Vrije Universiteit Brussel, The Board of Trustees of the Leland Stanford Junior University, TraskBritt P C, September 27, 2016: US09453065

The disclosure relates to the field of GPCR structure biology and signaling. In particular, it relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, it provides protein bi ...


3
Jan Steyaert, Juan Jose Fung, Brian Kobilka, Toon Laeremans, Els Pardon, Soren G F Rasmussen: Protein binding domains stabilizing functional conformational states of GPCRs and uses thereof. VIB VZW, Vrije Universiteit Brussel, The Board of Trustees of the Leland Stanford Junior University, TraskBritt P C, June 27, 2017: US09689872

The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifical ...


4
Els Pardon, Jan Steyaert, Lode Wyns: Epitope tag for affinity-based applications. VIB VZW, Vrije Universiteit Brussel, TraskBritt P C, December 13, 2016: US09518084

Described is an epitope tag useful in affinity-based applications. The invention further includes fusion proteins, methods for preparing fusion proteins, nucleic acid molecules encoding these fusion proteins and recombinant host cells that contain these nucleic acid molecules. The invention also rel ...



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