1
Alberto A Gabizon, Eliezer Kedar, Yechezkel Barenholz: Combined chemo-immunotherapy with liposomal drugs and cytokines. Yissum Research Development Company of the Hebrew University of Jerusalem, Hadasit Medical Research Services and Development, Browdy and Neimark, September 7, 2004: US06787132 (18 worldwide citation)

A method of antitumor therapy is described in which administration of a chemotherapeutic drug, encapsulated in liposomes, is supplemented by administration of an immunostimulating cytokine. The cytokine is preferably also encapsulated in liposomes. In tumor models for lung and colon carcinomas, this ...


2
Eliezer Kedar, Ilan Babai, Yechezkel Barenholz: Liposomal influenza vaccine composition and method. Yissum Research Development Company of the Hebrew University of Jerusalem, LeeAnn Gorthey, July 6, 1999: US05919480 (15 worldwide citation)

Subunit influenza vaccines containing an influenza H/N antigen and a cytokine immunopotentiator, where at least one and preferably both are encapsulated in liposomes, are described. The vaccines stimulate a strong humoral and CTL response. Also described are methods of immunization using such vaccin ...


3
Yechezkel Barenholz, Aviva Joseph, Eliezer Kedar: Sphingoid polyalkylamine conjugates for vaccination. Yissum Research Development Company of the Hebrew University of Jerusalem, Biolab, Browdy and Neimark PLLC, March 18, 2014: US08673285

The present invention concerns the use of a sphingoid-polyalkylamine conjugate as a capturing agent of biologically active molecules, such as antigens. In a particular embodiment, the spinogid-polyalkylamines are used for the preparation of pharmaceutical composition for modulating the immune respon ...


4
Yechezkel Bareholz, Eliezer Kedar, Sarit Samira: Sphingoid polyalkylamine conjugates for Hepatitis B virus vaccination. Yissum Research Development Company of the Hebrew University of Jersusalem, Biolab, Nasvax, Browdy and Neimark PLLC, March 15, 2011: US07906122

The present invention concerns the use of a sphingoid-polyalkylamine conjugate as a capturing agent of biologically active molecules, such as antigens. In a particular embodiment, the spinogid-polyalkylamines are used for the preparation of pharmaceutical composition for stimulating or enhancing an ...


5
Yechezkel BARENHOLZ, Eliezer Kedar, Sarit Samira: Sphingoid polyalklamine conjugates, isomers and uses thereof. Yissum Research Development Company of the Hebrew University of Jerusalem, BioLab, NasVax, Browdy And Neimark Pllc, November 15, 2007: US20070264273-A1

The present application discloses methods for stimulating or enhancing an immune response of a subject to protect against an infection caused by an agent selected from Hepatitis B Virus (HBV), avian influenza virus, the bacterium Bacillus anthracis or the bacterium Streptococcus pneumoniae, the meth ...


6
Yechezkel Barenholz, Eliezer Kedar, Aviva Joseph: Method for preparation of vesicles loaded with biological material and different uses thereof. Yissum Research Development Company Of The Hebrew University Of Jerusalem, Nath & Associates, February 9, 2006: US20060029655-A1

The present invention discloses a method for an efficient entrapment of active biological material in liposomes. The method is based on the steps of drying a suspension of liposome-forming lipids and then hydrating the dry composition obtained with an aqueous solution containing a biologically activ ...


7
Yechezkel Bareholz, Eliezer Kedar, Sarit Samira: Sphingoid polyalkylamine conjugates for hepatitis B virus vaccination. Yissum Research Development Company of the Hebrew University of Jerusalem, Biolab, NasVax, Browdy And Neimark Pllc, August 3, 2006: US20060171956-A1

The present invention concerns the use of a sphingoid-polyalkylamine conjugate as a capturing agent of biologically active molecules, such as antigens. In a particular embodiment, the spinogid-polyalkylamines are used for the preparation of pharmaceutical composition for stimulating or enhancing an ...


8
Yechezkel Barenholz, Aviva Joseph, Eliezer Kedar: Sphingoid polyalkylamine conjugates for vaccination. Yissum Research Development Company of the Hebrew University of Jerusalem, Browdy And Neimark Pllc, November 9, 2006: US20060252717-A1

The present invention concerns the use of a sphingoid-polyalkylamine conjugate as a capturing agent of biologically active molecules, such as antigens. In a particular embodiment, the spinogid-polyalkylamines are used for the preparation of pharmaceutical composition for modulating the immune respon ...