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Egbertson Melissa S, Hartman George D, Halczenko Wasyl, Laswell William L: Novel fibrinogen receptor antagonists.. Merck & Co, April 1, 1992: EP0478328-A1 (101 worldwide citation)

A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.


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Egbertson Melissa S, Laswell William L, Hartman George D, Duggan Mark E, Halczenko Wasyl: Novel sulfonamide fibrinogen receptor antagonists.. Merck & Co, April 1, 1992: EP0478363-A2 (75 worldwide citation)

A series of non-peptide derivatives of generic formula I that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation. i


3
Duggan Mark E, Ihle Nathan, Hartman George, Turchi Laura M, Egbertson Melissa S, Hoffman William F: Fibrinogen receptor antagonists.. Merck & Co, November 11, 1992: EP0512831-A1 (56 worldwide citation)

Fibrinogen receptor antagonists of the formula: are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets.


4
Egbertson Melissa S, Gould Robert J, Hartman George D: Inhibiting osteoclast-mediated bone resorption using substituted phenyl derivatives.. Merck & Co, February 24, 1993: EP0528587-A1 (28 worldwide citation)

Compounds of the general formula Y is an integer of from 0 to 6 is chosen from: 0, SO2, -CONH-, -NHCO-, -CH2- or R is substituted or unsubstituted mono- or polycyclic saturated hetero-cyclic ring system having 1, 2 or 3 heteroatoms where said heteroatoms are independently chosen from N, O and S and ...


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Egbertson Melissa S, Gould Robert J, Hartman George D: Inhibiting osteoclast-mediated bone resorption using aminoalkyl-substituted phenyl derivatives.. Merck & Co, February 24, 1993: EP0528586-A1 (22 worldwide citation)

Compounds of the general formula and the pharmaceutically acceptable salts thereof wherein n is an integer of from 0 to 6; Y is CH2, O, SO2, -CONH-, -NHCO-, or R and R are independently hydrogen, C1-8 alkyl, heterocyclyl C0-4 alkyl, aryl C0-4 alkyl, amino C1-4 alkyl, C1-4 alkylamino C1-4 alkyl, or C ...


7
Coburn Craig A, Egbertson Melissa S, Graham Samuel L, Mcgaughey Georgia B, Stauffer Shaun R, Yang Wenjin, Lu Wanli, Fahr Bruce: Spiropiperidine beta-secretase inhibitors for the treatment of alzheimers disease. Merck & Co, Sunesis Pharmaceuticals, Coburn Craig A, Egbertson Melissa S, Graham Samuel L, Mcgaughey Georgia B, Stauffer Shaun R, Yang Wenjin, Lu Wanli, Fahr Bruce, MERCK 126 East Lincoln Avenue Rahway New Jersey 07065 0907, January 25, 2007: WO/2007/011810 (19 worldwide citation)

The present invention is directed to spiropiperidine compounds of formula (I) and tautomers thereof, which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also d ...


8
Wai John S, Vacca Joseph P, Zhuang Linghang, Kim Boyoung, Lyle Terry A, Wiscount Catherine M, Egbertson Melissa S, Neilson Lou Anne, Embrey Mark, Fisher Thorsten E, Staas Donnette D: Hiv integrase inhibitors. Merck & Co, Wai John S, Vacca Joseph P, Zhuang Linghang, Kim Boyoung, Lyle Terry A, Wiscount Catherine M, Egbertson Melissa S, Neilson Lou Anne, Embrey Mark, Fisher Thorsten E, Staas Donnette D, MERCK 126 East Lincoln Avenue Rahway New Jersey 07065 0907, November 24, 2005: WO/2005/110414 (10 worldwide citation)

Hydroxy-substituted pyrazinopyrrolopyridazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I) wherein R1, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds are useful in the prevention and treatmen ...


9
Coburn Craig A, Egbertson Melissa S, Graham Samuel L, Mcgaughey Georgia B, Stauffer Shaun R, Rajapakse Hemaka A, Nantermet Philippe G, Stachel Shawn R, Yang Wenjin, Lu Wanli, Fahr Bruce: Spiropiperidine beta-secretase inhibitors for the treatment of alzheimers disease. Merck & Co, Sunesis Pharmaceuticals, Coburn Craig A, Egbertson Melissa S, Graham Samuel L, Mcgaughey Georgia B, Stauffer Shaun R, Rajapakse Hemaka A, Nantermet Philippe G, Stachel Shawn R, Yang Wenjin, Lu Wanli, Fahr Bruce, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, January 25, 2007: WO/2007/011833 (7 worldwide citation)

The present invention is directed to spiropiperidine compounds of formula (I) and tautomers thereof, which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also d ...


10
Wai John S, Vacca Joseph P, Zhuang Linghang, Kim Boyoung, Lyle Terry A, Wiscount Catherine M, Egbertson Melissa S, Neilson Lou Anne, Embrey Mark, Fisher Thorsten E, Staas Donnette D: Hiv integrase inhibitors. Merck & Co, Wai John S, Vacca Joseph P, Zhuang Linghang, Kim Boyoung, Lyle Terry A, Wiscount Catherine M, Egbertson Melissa S, Neilson Lou Anne, Embrey Mark, Fisher Thorsten E, Staas Donnette D, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, November 24, 2005: WO/2005/110415 (5 worldwide citation)

Hydroxy-substituted pyrazinopyrrolopyridazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula I: (I) wherein R1, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds are useful in the prevention and treat ...