1
Edwin F Ullman, Moshe Schwarzberg: Fluorescence quenching with immunological pairs in immunoassays. Syva Company, Townsend and Townsend, December 7, 1976: US03996345 (858 worldwide citation)

Immunoassays employing antibodies and a fluorescer-quencher (F-Q) chromophoric pair, wherein one or both of the chromophoric pair are bonded to antibodies. Depending on the particular ligand of interest, various reagent combinations can be employed, where the amount of quenching is directly related ...


2
David J Litman, Zvi Harel, Edwin F Ullman: Macromolecular environment control in specific receptor assays. Syva Company, Bertram I Rowland, June 23, 1981: US04275149 (636 worldwide citation)

Method and compositions are provided for performing protein binding assays involving a homologous pair consisting of ligand and receptor for the ligand. The method employs a label conjugated to a member of said homologous pair and a uniformly dispersed discontinuous phase of discrete particles in a ...


3
Edwin F Ullman, Pyare Khanna, Rohan Peries: Immunoassay device. Syntex, Gerald F Swiss, Theodore J Leitereg, August 15, 1989: US04857453 (280 worldwide citation)

A device is disclosed for conducting an assay method. The device comprises a housing, means enclosed in the housing for capturing a member of a specific binding pair in a zone and for allowing liquid to be transported by capillary action away from the zone, one or more self-contained liquid reagents ...


4
David J Litman, Edwin F Ullman: Test strip kits in immunoassays and compositions therein. Syva Company, Bertram I Rowland, July 5, 1983: US04391904 (243 worldwide citation)

An assay method and compositions are provided for determining the presence of an analyte in a sample. The analyte is a member of an immunological pair (mip) of immunogens--ligand and receptor. The method has two basic elements: a solid surface to which one of the members of the immunological pair is ...


5
David J Litman, Edwin F Ullman: Preferential signal production on a surface in immunoassays. Syva Company, Bertram I Rowland, November 10, 1981: US04299916 (216 worldwide citation)

An assay method and compositions are provided for determining the presence of an analyte in a sample. The analyte is a member of an immunological pair (mip) of immunogens--ligand and receptor. The method has two basic elements: a solid surface to which one of the members of the immunological pair is ...


6
Edwin F Ullman, Gregory B Stauber: Capillary assays involving separation of free and bound species. ACLARA Biosciences, Bertram I Rae Venter Law Group P C Rowland, August 15, 2000: US06103537 (205 worldwide citation)

The present invention concerns methods for masking inhomogeneity of a member of a specific binding pair (sbp) employed in a capillary electroseparation. The method comprises binding the sbp member to synthetic particles that become localized during capillary electroseparation. Also disclosed is one ...


7
Edward T Maggio, Richard L Wife, Edwin F Ullman: Reagents and method employing channeling. Syva Company, Bertram I Rowland, November 11, 1980: US04233402 (183 worldwide citation)

Method and compositions are provided for chemical analysis of an analyte which is a member of a specific binding pair of organic substances consisting of ligand and ligand receptor (antiligand). The method involves bringing together the following reagents with the analyte in an aqueous assay medium ...


8
Robert F Zuk, Ian Gibbons, Gerald L Rowley, Edwin F Ullman: Double antibody for enhanced sensitivity in immunoassay. Syva Company, Bertram I Rowland, July 28, 1981: US04281061 (173 worldwide citation)

Method and compositions are provided for performing homogeneous immunoassays. The method involves having a signal producing system, which provides a detectable signal, which system includes a macromolecular member. The determination of the analyte, which is a member of a specific binding pair consis ...


9
Edwin F Ullman, Thomas C Goodman, Paul D Stull: Method for detection of specific nucleic acid sequences. Syntex, Theodore J Leitereg, Mark L Bosse, February 9, 1993: US05185243 (168 worldwide citation)

A method is disclosed for detecting the presence of a target nucleotide sequence in a polynucleotide. The method comprises hybridizing a first nucleotide sequence and a second nucleotide sequence to non-contiguous portions of a target nucleotide sequence, covalently attaching the first and second se ...


10
Litai Weng, David Calderhead, Pyare Khanna, Edwin F Ullman: Concentrating immunochemical test device and method. Syntex, Theodore J Leitereg, April 26, 1988: US04740468 (167 worldwide citation)

A method and device for determining the presence of an analyte in a sample suspected of containing the analyte is disclosed. The method involves contacting a test solution containing the sample and a first member of a specific binding pair with an end portion of a strip of bibulous material capable ...