1
Alan J Korman, Edward L Halk, Nils Lonberg, Yashwant M Deo, Tibor P Keler: Human CTLA-4 antibodies. Medarex, Darby & Darby, January 10, 2006: US06984720 (70 worldwide citation)

The present invention provides human sequence antibodies against CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies.


2
Kazuma Tomizuka, Isao Ishida, Nils Lonberg, Edward L Halk: Transgenic transchromosomal rodents for making human antibodies. Medarex, Kirin Brewery Company, Darby & Darby P C, May 9, 2006: US07041870 (49 worldwide citation)

The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.


3
Alan J Korman, Edward L Halk, Nils Lonberg, Yashwant M Deo, Tibor P Keler: Human CTLA-4 antibodies and their uses. Medarex, Baker Botts, October 20, 2009: US07605238 (16 worldwide citation)

The present invention provides human sequence antibodies against human CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies.


4
Maria Jure Kunkel, Laura J Hefta, Marc Santoro, Subinay Ganguly, Edward L Halk: Fully human antibodies against human 4-1BB. Bristol Myers Squibb Company, Paul D Golian, October 30, 2007: US07288638 (5 worldwide citation)

Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating a disease in a subject comprising administering a therapeuticall ...


5
Alan J Korman, Edward L Halk, Nils Lonberg, Yashwant M Deo, Tibor P Keler: Human CTLA-4 antibodies and their uses. Medarex, Baker Botts L, September 13, 2011: US08017114 (4 worldwide citation)

The present invention provides novel human sequence antibodies against human CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies.


6
Kazuma Tomizuka, Isao Ishida, Nils Lonberg, Edward L Halk: Transgenic transchromosomal rodents for making human antibodies. Kyowa Hakko Kirin, Medarex, Baker Botts L, October 19, 2010: US07816578 (3 worldwide citation)

The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.


7
Kazuma Tomizuka, Isao Ishida, Nils Lonberg, Edward L Halk: Transgenic transchromosomal rodents for making human antibodies. Medarex, Kyowa Hakko Kirin, Baker Botts L, August 18, 2009: US07576258 (3 worldwide citation)

The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.


8
Maria Jure Kunkel, Laura J Hefta, Marc Santoro, Subinay Ganguly, Edward L Halk: Fully human antibodies against human 4-1BB. Bristol Myers Squibb Company, Paul D Golian, March 20, 2012: US08137667 (3 worldwide citation)

Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating a disease in a subject comprising administering a therapeuticall ...


9
Kazuma Tomizuka, Isao Ishida, Nils Lonberg, Edward L Halk: Transgenic trasnchromosomal rodents for making human antibodies. Medarex L L C, Kyowa Hakko Kirin, Baker Botts L, September 16, 2014: US08835712 (2 worldwide citation)

The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.


10
Maria Jure Kunkel, Laura J Hefta, Marc Santoro, Subinay Ganguly, Edward L Halk: Fully human antibodies against human 4-1BB. Bristol Myers Squibb Company, Paul D Golian, May 6, 2014: US08716452 (2 worldwide citation)

Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating a disease in a subject comprising administering a therapeuticall ...