1
Chien Hsing Chang, David M Goldenberg, William J McBride, Edmund A Rossi: Stably tethered structures of defined compositions with multiple functions or binding specificities. IBC Pharmaceuticals, Richard A Nakashima, April 21, 2009: US07521056 (73 worldwide citation)

The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments concern stably tethered structures comprising a homodimer of a first monomer, comprising a dimerization an ...


2
Chien Hsing Chang, David M Goldenberg, William J McBride, Edmund A Rossi: Methods and compositions for generating bioactive assemblies of increased complexity and uses. IBC Pharmaceuticals, Richard A Nakashima, May 19, 2009: US07534866 (72 worldwide citation)

The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In particular embodiments, the bioactive assembly is formed using dock-and-lock (DNL) methodology, which ta ...


3
Chien Hsing Chang, David M Goldenberg, Edmund A Rossi: Multivalent immunoglobulin-based bioactive assemblies. IBC Pharmaceuticals, Richard A Nakashima, May 5, 2009: US07527787 (71 worldwide citation)

The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Preferred embodiments concern hexameric stably tethered structures comprising one or more IgG antibody fragments and w ...


4
Chien Hsing Chang, David M Goldenberg, William J McBride, Edmund A Rossi: Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses. IBC Pharmaceuticals, Richard A Nakashima, June 23, 2009: US07550143 (70 worldwide citation)

The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular embodiments concern homodimers comprising monomers that contain a dimerization and docking domain attached ...


5
Chien Hsing Chang, David M Goldenberg, William J McBride, Edmund A Rossi: PEGylation by the dock and lock (DNL) technique. IBC Pharmaceuticals, Richard A Nakashima, February 23, 2010: US07666400 (68 worldwide citation)

The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using dock-and-lock technology, by attaching a therapeutic agent to a DDD sequence and attaching a PEG moiety to a ...


6
Chien Hsing Chang, David M Goldenberg, William J McBride, Edmund A Rossi: Stably tethered structures of defined compositions with multiple functions or binding specificities. IBC Pharmaceuticals, Richard A Nakashima, January 18, 2011: US07871622 (38 worldwide citation)

The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments concern stably tethered structures comprising a homodimer of a first monomer, comprising a dimerization an ...


7
Chien Hsing Chang, David M Goldenberg, Edmund A Rossi: Multivalent immunoglobulin-based bioactive assemblies. IBC Pharmaceuticals, Richard A Nakashima, December 28, 2010: US07858070 (37 worldwide citation)

The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Preferred embodiments concern hexameric stably tethered structures comprising one or more IgG antibody fragments and w ...


8
Chien Hsing Chang, David M Goldenberg, William J McBride, Edmund A Rossi: Methods and compositions for generating bioactive assemblies of increased complexity and uses. IBC Pharmaceuticals, Richard A Nakashima, March 15, 2011: US07906121 (36 worldwide citation)

The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In particular embodiments, the bioactive assembly is formed using dock-and-lock (DNL) methodology, which ta ...


9
Chien Hsing Chang, David M Goldenberg, William J McBride, Edmund A Rossi: Dimeric alpha interferon pegylated site-specifically shows enhanced and prolonged efficacy in vivo. IBC Pharmaceuticals, Richard A Nakashima, August 23, 2011: US08003111 (34 worldwide citation)

The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using dock-and-lock technology, by attaching a therapeutic agent to a DDD sequence and attaching a PEG moiety to a ...


10
Chien Hsing Chang, David M Goldenberg, Edmund A Rossi: Modular method to prepare tetrameric cytokines with improved pharmacokinetics by the dock-and-lock (DNL) technology. IBC Pharmaceuticals, Richard A Nakashima, March 15, 2011: US07906118 (34 worldwide citation)

The present invention concerns methods and compositions for forming cytokine-antibody complexes using dock-and-lock technology. In preferred embodiments, the cytokine-MAb DNL complex comprises an IgG antibody attached to two AD (anchor domain) moieties and four cytokines, each attached to a DDD (doc ...