1
Alig Leo Dr, Edenhofer Albrecht Dr, Mueller Marcel Dr, Trzeciak Arnold, Weller Thomas Dr: Carboxylic-acid and sulphonic-acid amides.. Hoffmann La Roche, August 8, 1990: EP0381033-A1 (95 worldwide citation)

The novel carboxylic acid and sulphonic acid amides of the formula R-A-(W)a-X-(CH2)b-(Y)c-B-Z-COOR (I) in which R, A, W, X, Y, B, Z, R, a, b and c have the meaning given in the description, can be used in the treatment of thromboses, apoplexy, cardiac infarcts, inflammations, arteriosclerosis and tu ...


2
Alig Leo Dr, Edenhofer Albrecht Dr, Muller Marcel Dr, Trzeciak Arnold, Weller Thomas Dr: Benzoic-acid phenylacetic-acid derivatives, their preparation and their use as medicines.. Hoffmann La Roche, June 13, 1990: EP0372486-A2 (88 worldwide citation)

Die Verbindungen der Formel worin R, R und R die in der Beschreibung angegebene Bedeutung haben, können als Heilmittel zur Therapie und Prophylaxe von Erkrankungen wie Thrombose, Hirn- oder Herzinfarkt, Entzündungen und Arteriosklerose sowie zur Behandlung von Tumoren verwendet werden.


3
Alig Leo Dr, Edenhofer Albrecht Dr, Mueller Marcel Dr, Trzeciak Arnold, Weller Thomas Dr: Derivatives of acetic acid.. Hoffmann La Roche, September 11, 1991: EP0445796-A2 (70 worldwide citation)

Acetic acid derivatives of the formula H2N(HN)C-X-Y-CO-Z-CH(Q)COOQ I in which X, Y, Z, Q and Q have the meaning indicated in the description, and hydrates, solvates and physiologically utilisable salts thereof inhibit the binding of adhesive proteins to blood platelets and inhibit blood platelet agg ...


4
Alig Leo Dr, Edenhofer Albrecht Dr, Mueller Marcel Dr, Trzeciak Arnold, Weller Thomas Dr: Glycinderivatives.. Hoffmann La Roche, August 29, 1990: EP0384362-A2 (48 worldwide citation)

The glycine derivatives of the formula R-CONH-CH2-CONH-CH(R')-CH2COOH I in which R is a group of the formula -CH(NH-R)-(CH2)1-6-NH-R (R-1> -(T)1 or 0-C6H4-CH2NH-R (R-2> (T)1 or 0-C6H4-(NH)n-C(NH)-L (R-3> or and R is hydrogen, -COO-C1-4-alkyl, Z, -COC6H5, -COC6H4N3, -SO2C6H5, -SO2-naphthyl or -COCH2N ...


5
Branca Quirico Dr, Edenhofer Albrecht Dr, Martin Joseph Armstrong, Merrett John Herbert, Neidhart Werner Dr: Amino acid derivatives.. Hoffmann La Roche, September 12, 1990: EP0386611-A2 (23 worldwide citation)

Compounds of the formula wherein R represents alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, aralkanoyl, aroyl, cycloalkylcarbonyl, heterocyclylcarbonyl, heterocyclyl-alkanoyl, 6-(dibenzylcarbamoyl)-4-oxohexanoyl or an acyl group of an alpha -amino acid in which the amino group is substituted by alkoxy ...


6
Branca Quirico Dr, Edenhofer Albrecht Dr, Gutknecht Eva Maria Dr, Neidhart Werner Dr, Ramuz Henri Prof Dr, Wostl Wolfgang Dr: Peptide-like amino-acid derivatives.. Hoffmann La Roche, April 12, 1989: EP0310918-A2 (23 worldwide citation)

Compounds of the formula in which R, R, R, R and A have the meaning given in Claim 1, and pharmaceutically utilisable salts thereof have renin-inhibiting properties and can therefore be used in the form of pharmaceutical preparations as medicaments. They can be prepared by methods which are known pe ...


7
Branca Quirico Dr, Edenhofer Albrecht Dr, Maerki Hans Peter Dr, Neidhart Werner Dr, Ramuz Henri Prof Dr, Wostl Wolfgang Dr: Peptide derivatives of amino acids having a renin-inhibiting effect.. Hoffmann La Roche, October 10, 1990: EP0391180-A2 (4 worldwide citation)

The compounds of the formula in which A, R, R, R, R, R and n have the meaning stated in Claim 1, in the form of optically pure diastereomers, diastereomer mixtures, diastereomeric racemates or mixtures of diastereomeric racemates, and pharmaceutically utilisable salts thereof inhibit the action of t ...


8
Cassal Jean Marie Dr, Edenhofer Albrecht Dr, Ramuz Henri Prof Dr: Polycyclic salts.. Hoffmann La Roche, July 30, 1986: EP0189094-A2

Polycyclische Salze der Formel AXN-CH2-(Y)n-(CH2)p-(Z)q-L-(T)r-M I worin A das Anion einer starken organischen oder anorganischen Säure ist, XN durch R, R und R substituiertes Pyridinium, Pyrimidinium, Thiazolium oder Imidazolium, n, q und r die Zahl 1 oder 0 und p eine ganze Zahl zwischen 1 und 15, ...