1
Samuel Weiss, Brent Reynolds, Joseph P Hammang, E Edward Baetge: In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny. NeuroSpheres Holdings, David J Brezner, Jan P Brunelle, Flehr Hohbach Test Albritton & Herbert, May 12, 1998: US05750376 (244 worldwide citation)

A method for producing genetically modified neural cells comprises culturing cells derived from embryonic, juvenile, or adult mammalian neural tissue with one or more growth factors that induce multipotent neural stem cells to proliferate and produce multipotent neural stem cell progeny which includ ...


2
Samuel Weiss, Brent Reynolds, Joseph P Hammang, E Edward Baetge: In vitro growth and proliferation of multipotent neural stem cells and their progeny. Neurospheres, Flehr Hohbach Test Albrition & Herbert, December 22, 1998: US05851832 (209 worldwide citation)

A method for the in vitro proliferation and differentiation of neural stem cells and stem cell progeny comprising the steps of (a) isolating the cells from a mammal, (b) exposing the cells to a culture medium containing a growth factor, (c) inducing the cells to proliferate, and (d) inducing the cel ...


3
Samuel Weiss, Brent Reynolds, Joseph P Hammang, E Edward Baetge: Neural transplantation using proliferated multipotent neural stem cells and their progeny. NeuroSpheres Holdings, Ivor R Elrifi Esq, Christine V Karnakis Esq, Mintz Levin Cohn Ferris Glovsky and Popeo P C, December 24, 2002: US06497872 (111 worldwide citation)

The invention provides methods of transplanting multipotent neural stem cell progeny to a host by obtaining a population of cells derived from mammalian neural tissue containing at least one multipotent CNS multipotent neural stem cell; culturing the neural stem cell in a culture medium containing o ...


4
Joseph P Hammang, E Edward Baetge, William G Tsiarias, Peter D Spear: Device and method for treating ophthalmic diseases. Neurotech, Ivor R Elrifi, Mintz Levin Cohn Ferris Glovsky and Popeo P C, October 9, 2001: US06299895 (76 worldwide citation)

A method and device for delivering a biologically active molecule to the eye, either intraocularly or periocularly, and method and device for treating ophthalmic disorders in a patient suffering therefrom.


5
Joseph P Hammang, E Edward Baetge, Peter D Spear, William G Tsiaras: Method for treating ophthalmic diseases. CytoTherapeutics, Mintz Levin Cohn Ferris Glovsky and Popeo P C, May 18, 1999: US05904144 (71 worldwide citation)

The present invention provides novel devices and methods for continuous, controlled delivery of a biologically active molecule to the eye, either intraocularly or periocularly, to treat ophthalmic disorders. A capsule is surgically placed in the desired location in the eye. The capsule includes cell ...


6
Samuel Weiss, Brent Reynolds, Joseph P Hammang, E Edward Baetge: In vivo genetic modification of growth factor-responsive neural precursor cells. NeuroSpheres Holdings, Burns Doane Swecker & Mathis L, June 6, 2000: US06071889 (59 worldwide citation)

Methods for administering genetic material to dividing neural precursor cell populations in vivo are provided. The genetic material may comprise useful genes for neurotransmitters, growth factors, growth factor receptors, and the like. The genetic material is administered to the brain with one or mo ...


7
Joseph P Hammang, E Edward Baetge, William G Tsiarias, Peter D Spear: Device and method for treating ophthalmic diseases. Neurotech, Ivor R Elrifi Esq, Christina V Karnakis Esq, Mintz Levin Cohn Ferris Glovsky and Popeo P C, August 20, 2002: US06436427 (51 worldwide citation)

The invention provides a method for delivering biologically active molecules to the eye by implanting biocompatible capsules containing a cellular source of the biologically active molecule. Also provided is a method of treating ophthalmic diseases using biocompatible capsules.


8
Samuel Weiss, Brent Reynolds, Joseph P Hammang, E Edward Baetge: Use of multipotent neural stem cells and their progeny for the screening of drugs and other biological agents. Neurospheres Holdings, Ivor R Elrifi Esq, Mintz Levin Cohn Ferris Glovsky and Popeo P C, September 25, 2001: US06294346 (44 worldwide citation)

A culture method for determining the effect of a biological agent on multipotent neural stem cell progeny is provided. In the presence of growth factors, multipotent neural stem cells are induced to proliferate in culture. The multipotent neural stem cells may be obtained from normal neural tissue o ...


9
Stephen Dalton, Allan Sheppard, Karen Jones, E Edward Baetge, Kevin A D Amour, Alan D Agulnick: Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors. University of Georgia Research Foundation, ViaCyte, The Law Office of Jane K Babin Professional Corporation, Jane K Babin, May 29, 2012: US08187878 (25 worldwide citation)

The present invention provides compositions and methods for the production of differentiated mammalian cells. More particularly, the present invention provides cellular differentiation methods employing culturing the cells on a feeder layer or under feeder-free conditions in cell culture and further ...


10
E Edward Baetge, Thomas Hunziker, Alain Limat, Vincent Ronfard: Cell paste comprising keratinocytes and fibroblasts. Modex Therapeutiques, Ivor R Elrifi Esq, Christina V Karnakis Esq, Mintz Levin Cohn Ferris Glovsky and Popeo P C, January 6, 2004: US06673603 (22 worldwide citation)

The present invention provides the use and composition of matter of angiogenic or other growth factors expressed by combining various types and stages of differentiation of allogeneic human cell strains or lines in unencapsulated pastes (mixed with or applied to extracellular matrix material or synt ...