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Maccoss Malcolm, Olsen David B, Leone Joseph, Durette Philippe L: Fluorinated pyrrolo[2,3-d]pyrimidine nucleosides for the treatment of rna-dependent rna viral infection. Merck & Co, Maccoss Malcolm, Olsen David B, Leone Joseph, Durette Philippe L, MERCK 126 East Lincoln Avenue Philippe L Durette Rahway NJ 07065 0907, June 22, 2006: WO/2006/065335 (55 worldwide citation)

The present invention provides fluorinated pyrrolo[2,3,d]pyrimidine nucleoside compounds which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are p ...


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Carroll Steven S, Olsen David B, Durette Philippe L, Bhat Balkrishen, Dande Prasad, Eldrup Anne B: Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase. Merck & Co, Isis Pharmaceuticals, Carroll Steven S, Olsen David B, Durette Philippe L, Bhat Balkrishen, Dande Prasad, Eldrup Anne B, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, December 31, 2003: WO/2004/000858 (51 worldwide citation)

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are partic ...


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Meppen Malte, Narjes Frank, Pacini Barbara, Gardelli Cristina, Durette Philippe L: Nucleoside cyclic phosphoramidates for the treatment of rna-dependent rna viral infection. Merck & Co, Istituto Di Ricerche Di Biologia Molecolare P Angeletti, Meppen Malte, Narjes Frank, Pacini Barbara, Gardelli Cristina, Durette Philippe L, MERCK 126 East Lincoln Avenue Rahway New Jersey 07065 0907, July 3, 2008: WO/2008/079206 (30 worldwide citation)

The present invention provides nucleoside cyclic phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent ...


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Narjes Frank, Gardelli Cristina, Donghi Monica, Attenni Barbara, Durette Philippe L: Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection. Merck & Co, Istituto Di Ricerche Di Biologia Molecolare P Angeletti, Narjes Frank, Gardelli Cristina, Donghi Monica, Attenni Barbara, Durette Philippe L, MERCK 126 East Lincoln Avenue Rahway New Jersey 07065 0907, July 17, 2008: WO/2008/085508 (27 worldwide citation)

The present invention provides nucleoside aryl phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RN ...


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Durette Philippe L, Kollonitsch Janos, Pessolano Arsenio A: Novel immunosuppressive fluorinated cyclosporin analogs. Merck & Co, February 8, 1989: GB2207678-A (25 worldwide citation)

New cyclosporin analogs containing fluorinated amino acid residues at the various positions around the ring have been synthesized end found to exhibit unexpectedly superior activity over cyclosporin A as immunosuppressive agents.


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Tischler Allan N, Durette Philippe L, Witzel Bruce E, Rupprecht Kathleen M, Gallagher Timothy F, Goldenberg Marvin M, Allison Debra L: Benzothiophenes, their production and use, and compositions containing them.. Merck & Co, November 6, 1985: EP0160408-A1 (19 worldwide citation)

N-Alkenyl-3-hydroxybenzo [b] thiophene-2-carboxamide derivatives of formula) and their pharmaceutically acceptable salts, are novel. In the formula, each of R, R, R, R and R is selected from various hydrocarbons (including heteroaryl), acyl, and acyl-substituted hydrocarbon groups and their ring-sub ...


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Durette Philippe L, Pessolano Arsenio A, Kollonitsch Janos, Witzel Bruce E: Immunosuppressive fluorinated cyclosporin analogs. Merck & Co, July 25, 1990: GB2227244-A (12 worldwide citation)

Immunosuppressive cyclosporin analogs are disclosed having one or more fluorinated amino acids. These analogs may also have a "C-9 amino acid" wherein the double bond is replaced by a hetero-atom such as sulfur or oxygen.


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