1
Carini David John, Duncia John Jonas Vytautas: Angiotensin ii receptor blocking imidazoles.. Du Pont, January 20, 1988: EP0253310-A2 (316 worldwide citation)

Substituted imidazoles such as are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.


2
Carini David John, Wong Pancras Chor Bun, Duncia John Jonas Vytautas: Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids.. Du Pont, July 19, 1989: EP0324377-A2 (169 worldwide citation)

The invention encompasses a pharmaceutical composition comprising a diuretic or a non-steroidal antiinflammatory drug, a pharmaceutical suitable carrier and an antihypertensive and processes for production of these compositions.


3
Carini David John, Wells Gregory James, Duncia John Jonas Vytautas: Substituted pyrrole, pyrazole and triazole angiotensin ii antagonists.. Du Pont, July 12, 1989: EP0323841-A2 (153 worldwide citation)

Substituted pyrroles, pyrazoles and triazoles of the formula and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.


4
Aldrich Paul Edward, Pierce Michael Ernest, Duncia John Jonas Vytautas: Tetrazole intermediates to antihypertensive compounds.. Du Pont, November 23, 1988: EP0291969-A2 (116 worldwide citation)

Tetrazole intermediates useful to prepare antihypertensive compounds described in coassigned application U.S. Ser. No. 884,920, filed July 11, 1986, are described, these tetrazoles have the formula: wherein X and X are as described in the specification. n


5
Carini David John, Duncia John Jonas Vytautas, Wong Pancras Chor Bun: Pharmaceutical compositions comprising angiotensin ii receptor blocking imidazoles and diuretics. Du Pont, September 25, 1996: EP0733366-A2 (17 worldwide citation)

The invention encompasses a pharmaceutical composition comprising a diuretic, a pharmaceutical suitable carrier and an antihypertensive and processes for production of these compositions.


6
Carini David John, Duncia John Jonas Vytautas, Wong Pancras Chor Bun: Treatment of chronic renal failure with imidazole angiotensin-ii receptor antagonists.. Du Pont, March 31, 1993: EP0533840-A1 (4 worldwide citation)

Substituted imidazoles such as 2-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-5-(hyd roxymethyl)imidazole and 2-butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]-5-(hydroxymethyl )imidazole and pharmaceutically acceptable salts thereof are useful for treating chronic renal failure ...


7
Carini David John, Duncia John Jonas Vytautas, Wong Pancras Chor Bun: Treatment of chronic renal failure with imidazole angiotensin-ii receptor antagonists. Ei Du Pont de Nemours And Company, CHRISTENBURY Lynne M, January 9, 1992: WO/1992/000067 (1 worldwide citation)

Substituted imidazoles such as 2-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-5-(hydroxymethyl)imidazole and 2-butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole and pharmaceutically acceptable salts thereof are useful for treating chronic renal failure, ...


8
Amparo Eugene Cruz, Miller William Henry, Pacofsky Gregory James, Wityak John, Weber Patricia Carol, Duncia John Jonas Vytautas, Santella Joseph Basil Iii: Boronic acid and ester inhibitors of thrombin. Du Pont Merck Pharma, December 10, 1997: EP0810858-A2

Novel boronic acid and ester and carboxyl-modified amino acid compounds of formula (I): R-Z-CHR-A, which are inhibitors of trypsin-like enzymes, are disclosed, where R, Z, R and A are defined within.


9
Chiu Andrew Tak Chau, de Noble Victor John, Duncia John Jonas Vytautas, Wong Pancras Chor Bun: Treatment of central nervous system disorders with imidazole angiotensin-ii receptor antagonists. Du Pont, October 29, 1997: EP0803252-A2

Substituted imidazoles such as 2-butyl-4-chloro-1-Ä(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methylÜ-5-(hyd roxymethyl)imidazole and 2-butyl-4-chloro-1-Ä(2'-carboxybiphenyl-4-yl)methylÜ-5-(hydroxymethyl) imidazole and pharmaceutically acceptable salts thereof are useful for treating central nervous system ...


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