1
James L Winkler, Stephen P A Fodor, Christopher J Buchko, Debra A Ross, Lois Aldwin, Douglas N Modlin: Combinatorial strategies for polymer synthesis. Affymax Technologies, Townsend and Townsend and Crew, October 14, 1997: US05677195 (250 worldwide citation)

A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rota ...


2
Douglas N Modlin, Glenn R Edwards, Michael T Taylor, Samuel A Marquiss: Light detection device. LJL BioSystems, Kolisch Hartwell Dickinson McCormack & Heuser, June 6, 2000: US06071748 (187 worldwide citation)

A high-throughput light detection instrument and method are described. Confocal optics structure enables exclusive light detection from a sensed volume in a composition.


3
Douglas N Modlin, Glenn R Edwards, John C Owicki, Michael T Taylor, Samuel A Marquiss: Sample analysis systems. Molecular Devices Corporation, Kolisch Hartwell P C, January 3, 2006: US06982431 (182 worldwide citation)

Systems, and components thereof, for analyzing samples. These systems include apparatus and methods for generating, transmitting, detecting, and/or analyzing light, including without limitation high-throughput optical screening devices for analyzing samples at one or more assay sites. These systems ...


4
James L Winkler, Stephen P A Fodor, Christopher J Buchko, Debra A Ross, Lois Aldwin, Douglas N Modlin: Combinatorial strategies for polymer synthesis. Affymetrix, Banner & Witcoff, March 21, 2000: US06040193 (179 worldwide citation)

An array is created by moving a dispenser toward a solid support until a tip of the dispenser touches the support, withdrawing the tip from the surface and releasing a drop of 5 nanoliters or less in an area smaller than 1 mm.sup.2 to create an array of at least 100 spots.


5
Todd E French, Douglas N Modlin, John C Owicki, James S Richey, Lev J Leytes, Enal S Razvi: Methods and apparatus for detecting nucleic acid polymorphisms. LJL BioSystems, Kolisch Hartwell Dickinson McCormack & Heuser, October 2, 2001: US06297018 (150 worldwide citation)

Methods and apparatus for detecting polynucleotide hybridization in luminescence-based assays. The methods may include (1) allele-specific hybridization, using luminescence detection, (2) allele-specific oligonucleotide ligation, using dye-labeled oligonucleotide ligation with luminescence resonance ...


6
Douglas N Modlin, John C Owicki, Jon F Petersen, Todd E French, Carl L Wright, Jeanne A Ruiz, Lorne E Bechtel: Multi-mode light detection system. Molecular Devices Corporation, Kolisch Hartwell P C, November 30, 2004: US06825921 (108 worldwide citation)

Apparatus and methods for combining multiple modes and methods of optical detection, postprocessing, and/or feedback loops in bioanalytical measurements. The methods may include (1) positioning a composition at an examination site in a multi-mode instrument; (2) detecting light transmitted form the ...


7
Alejandro C Zaffaroni, Christopher J Buchko, Douglas N Modlin: Method of conducting a plurality of reactions. Townsend and Townsend and Crew, September 19, 2000: US06121048 (96 worldwide citation)

An apparatus and method is provided for preparing and using a very large and diverse array of compounds on a substrate having rapidly accessible locations. The substrate contains cells in which the compounds of the array are located. Surrounding the cells is a non-wetable surface that prevents the s ...


8
Douglas N Modlin, Glenn R Edwards, Michael T Taylor, Samuel A Marquiss, Amer El Hage, Craig S Barker, Lorne B Bechtel, Rick V Stellmacher, Philip A Granieri Jr, Robert M Lembi Sr: Light detection device having an optical-path switching mechanism. LJL BioSystems, Kolisch Hartwell Dickinson McCormack & Heuser, August 1, 2000: US06097025 (90 worldwide citation)

A high-throughput light detection instrument and method are described. In some embodiments, switch mechanisms and optical relay structures permit different light sources and/or detectors to be selected for different applications. In other embodiments, switch mechanisms and optical paths permit top/b ...


9
James L Winkler, Stephen P A Fodor, Christopher J Buchko, Debra A Ross, Lois Aldwin, Douglas N Modlin: Combinatorial kit for polymer synthesis. Affymetrix, Banner & Witcoff, October 24, 2000: US06136269 (77 worldwide citation)

A device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage ...


10
Samuel A Marquiss, Christopher G Cesar, Jon F Petersen, David P Stumbo, Amer El Hage, Glenn R Edwards, Douglas N Modlin, Lev J Leytes, Samuel Burd: Integrated sample-processing system. LJL Biosystems, Kolisch Hartwell P C, June 7, 2005: US06902703 (69 worldwide citation)

The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.