1
Gary B Gordon, Douglas J Dellinger: Methods and devices for carrying out chemical reactions. Agilent Technologies, June 26, 2001: US06251595 (129 worldwide citation)

Methods and devices are disclosed for carrying out multiple chemical reactions. A plurality of electrodes supported by a semiconductor substrate is brought into proximity with a reaction medium, which comprises reagents for carrying out the chemical reactions. An item of numerical data is sent to st ...


2
Douglas J Dellinger, SueAnn C Dahm, Mark A Troll: Signal enhancement method and kit. Hewlett Packard Company, December 29, 1998: US05853993 (78 worldwide citation)

The invention discloses and claims a signal amplification method for detecting a target nucleic acid analyte having a homopolymeric region and a target sequence. The method comprises (a) contacting an analyte under hybridizing conditions with a multiplicity of reporter probes, each probe including a ...


3
Douglas J Dellinger, SueAnn C Dahm, Diane D Ilsley, Robert A Ach, Mark A Troll: Hybridization assay signal enhancement. Agilent Technologies, Bill Kennedy, Gordon Stewart, August 15, 2000: US06103474 (58 worldwide citation)

A signal amplification method for detecting a target nucleic acid analyte having a homopolymeric region and a target sequence includes steps of: contacting an analyte under hybridizing conditions with a multiplicity of reporter probes, each reporter probe including a signal region and an oligonucleo ...


4
Geraldine Fulcrand, Douglas J Dellinger, Steven M Lefkowitz: Methods for attaching substances to surfaces. Agilent Technologies, November 20, 2001: US06319674 (57 worldwide citation)

Methods are disclosed for immobilizing a substance to a surface. A surface is employed that comprises a linking group consisting of a first portion comprising a hydrocarbon chain, optionally substituted, and a second portion comprising an alkylene oxide or an alkylene imine wherein the alkylene is o ...


5
Douglas J Dellinger, Agnieska Sierzchala, Marvin H Caruthers, Geraldine F Dellinger: 2′-silyl containing thiocarbonate protecting groups for RNA synthesis. Agilent Technologies, August 16, 2011: US07999087 (43 worldwide citation)

Nucleoside monomers, nucleic acids, e.g., oligonucleotides and polynucleotides, methods of making each, methods of deprotecting each, and the like are disclosed herein. Aspects of the invention include 2′ silyl containing thiocarbonate protecting groups. Corresponding compositions and methods are pr ...


6
Douglas J Dellinger, Brian Stell, Marvin H Caruthers: Protecting groups for RNA synthesis. Agilent Technologies, The Regents of the University of Colorado, August 14, 2012: US08242258 (41 worldwide citation)

Aspects of the invention include 2′ protected nucleoside monomers that are protected at the 2′ site with orthoester-type protecting groups. The 2′ protected monomers also include a second, aryl carbonate-type, protecting group. Aspects of the invention further include nucleic acids that include the ...


7
Douglas J Dellinger, Agnieszka Sierzchala, John Turner, Joel Myerson, Zoltan Kupihar, Fernando Ferreira, Marvin H Caruthers, Geraldine F Dellinger: Thiocarbon-protecting groups for RNA synthesis. Agilent Technologies, June 19, 2012: US08202983 (41 worldwide citation)

Aspects of the invention include 2′ protected nucleoside monomers that are protected at the 2′ site with thiocarbon protecting groups. Thiocarbon protecting groups of interest include thiocarbonate, thionocarbonate, dithiocarbonate groups, as well as thionocarbamate protecting groups. Aspects of the ...


8
Douglas J Dellinger, Marvin H Caruthers, Jason R Betley: Methods of synthesizing oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection. Agilent Technologies, November 13, 2012: US08309706 (41 worldwide citation)

The invention provides methods for synthesizing oligonucleotides using nucleoside monomers having carbonate protected hydroxyl groups that are deprotected with α-effect nucleophiles. The α-effect nucleophile irreversibly cleave the carbonate protecting groups while simultaneously oxidizing the inter ...


9
Douglas J Dellinger, Marvin H Caruthers, Jason R Betley: Solid phase synthesis of oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection. Agilent Technologies, April 24, 2001: US06222030 (32 worldwide citation)

The invention provides a method for synthesizing oligonucleotides using carbonate protection of hydroxyl groups and nucleophilic deprotection reagents. The deprotection reagents irreversibly cleave the carbonate protecting groups while simultaneously oxidizing the intemucleotide phosphite triester l ...


10
Steven M Lefkowitz, Geraldine Fulcrand, Douglas J Dellinger, Charles Z Hotz: Functionalization of substrate surfaces with silane mixtures. Agilent Technologies, Gordon Stewart, July 10, 2001: US06258454 (30 worldwide citation)

Low surface energy functionalized surfaces on solid supports are provided by treating a solid support having hydrophilic moieties on its surface with a derivatizing composition containing a mixture of silanes. A first silane provides the desired reduction in surface energy, while the second silane e ...