1
Robin F B Turner, Douglas G Kilburn, Michael R Phelps: Biosensor and interface membrane. The University of British Columbia University Industry Liaison Office, Christensen O Connor Johnson & Kindness PLLC, April 29, 1997: US05624537 (487 worldwide citation)

A regenerable biosensor probe adapted for positioning in a bioreactor comprises a selectively permeable interface membrane, a porous protein-receiving matrix adjacent to the interface membrane, an indicating electrode, an inlet conduit through which fresh protein conjugate may flow to the protein-re ...


2
Felix Trampler, James M Piret, Stefan A Sonderhoff, Douglas G Kilburn: Acoustic filter for separating and recycling suspended particles. SonoSep Biotech, Seed and Berry, May 6, 1997: US05626767 (85 worldwide citation)

Particulate material suspended in a fluid is separated and recycled by means of an ultrasonic resonance wave. In a preferred embodiment, the ultrasonic resonance field is generated within a multilayered composite resonator system including a transducer, the suspension and a mirror parallel to each o ...


3
Douglas G Kilburn, Robert C Miller, Richard A J Warren, Neil R Gilkes: Cellulose binding fusion proteins having a substrate binding region of cellulase. University of British Columbia, Barbara Rae Venter, April 13, 1993: US05202247 (68 worldwide citation)

A fusion protein is prepared containing a polypeptide such as an enzyme and an amino acid sequence having a substrate binding region of a polysaccharidase such as cellulase that has essentially no polysaccharidase activity. By contacting the fusion protein with an affinity matrix containing a substr ...


4
Douglas G Kilburn, Robert C Miller, Richard A J Warren, Neil R Gilkes: Cellulose binding fusion proteins for immobilization and purification of polypeptides. University of British Columbia, Barbara Rae Venter, August 11, 1992: US05137819 (43 worldwide citation)

A fusion protein is prepared containing a polypeptide such as an enzyme and an amino acid sequence having a substrate binding region of a polysaccharidase such as cellulase that has essentially no polysaccharidase activity. By contacting the fusion protein with an affinity matrix containing a substr ...


5
Douglas G Kilburn, Robert C Miller, Neil Gilkes, R Antony J Warren: Method of preparing a B-1,4 glycan matrix containing a bound fusion protein. University of British Columbia, Barbara Rae Venter, August 23, 1994: US05340731 (32 worldwide citation)

A fusion protein that can function as a removable label is prepared containing a polypetide such as an enzyme and an amino acid sequence having a substrate binding region of a polysaccharidase such as cellulase that has essentially no polysaccharidase activity. By contacting the fusion protein with ...


6
Charles A Haynes, Peter Tomme, Douglas G Kilburn: Purification of a polypeptide compound having a polysaccharide binding domain by affinity phase separation. University of British Columbia, Barbara Rae Venter, Rae Venter Law Group P C, January 16, 2001: US06174700 (15 worldwide citation)

A compound having a polysaccharide binding domain such as contained by a cellulose and essentially lacking in polysaccharidase activity is purified from other ingredients in a mixture using an affinity partition system. A mixture containing the compound is contacted with a system containing as a fir ...


7
Douglas G Kilburn, Robert C Miller, Richard A J Warren, Neil R Gilkes: Polysaccharide binding fusion proteins and conjugates. The University of British Columbia, Barbara Rae Venter Law Group P C Rae Venter, October 5, 1999: US05962289 (12 worldwide citation)

Fusion proteins or conjugates are provided containing an amino acid sequence having a substrate binding region of a polysaccharidase such as cellulase that binds to a .beta.-1,4-glycan matrix such as cellulose. The substrate binding region is essentially without polysaccharidase activity. In the fus ...


8
Douglas G Kilburn, Keith R Humphries, James G Doheny, Eric Jervis, Judie Alimonti: Compositions and methods for modulating cell proliferation using growth factor-polysaccharide binding fusion proteins. University of British Columbia, Barbara Rae Venter, Viola T Rae Venter Law Group P C Kung, February 23, 1999: US05874308 (12 worldwide citation)

Methods and compositions are provided for in vitro expansion of growth factor dependent cells. Expansion is effected through the use of growth factor conjugates that include a growth factor such as a steel factor and a polysaccharidase substrate binding region. The conjugates are immobilized by bind ...


9
Charles A Haynes, Peter Tomme, Douglas G Kilburn: Two-phase partition affinity separation system and affinity separated cell-containing composition. Univ of British Columbia, Rae Venter Law Group P C, April 11, 2000: US06048715 (11 worldwide citation)

A two-phase partition system is provided for affinity separation of a composition containing a polysaccharide binding peptide from a mixture such as a fermentation broth. The peptide may be from an enzyme and lacking in polysaccharidase activity such as the binding domain of cellulase that binds to ...


10
R Anthony J Warren, Douglas G Kilburn, Robert C Miller Jr: Characterization and structure of an endodglucanase gene of Cellulomonas fimi. University of British Columbia, Barbara Rae Venter, July 1, 1997: US05643791 (9 worldwide citation)

A biologically pure DNA sequence which encodes an endo 1,4-.beta.-glucanase, useful for the efficient conversion of cellulose to glucose, is disclosed. Also disclosed are recombinant DNA cloning vehicles (vectors) that contain nucleotide sequences that encode for the aforesaid endoglucanase, protein ...