1
James N Herron, Douglas A Christensen, Hsu Kun Wang, Karin D Caldwell, Vera Janatova, Shao Chie Huang: Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays. University of Utah Research Foundation, Trask Britt & Rossa, October 14, 1997: US05677196 (221 worldwide citation)

Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide with an integral semi-cylindrical lens, and has multi-analyte features and calibration features, along with improved evanescent field intensity. A preferred embodiment of the biosens ...


2
W Monty Reichert, James N Herron, Douglas A Christensen, Hsu Kun Wang: Composite waveguide for solid phase binding assays. University of Utah Research Foundation, Trask Britt & Rossa, November 3, 1998: US05832165 (114 worldwide citation)

A step-gradient composite waveguide for evanescent sensing in fluorescent binding assays comprises a thick substrate layer having one or more thin film waveguide channels deposited thereon. In one embodiment, the substrate is silicon dioxide and the thin film is silicon oxynitride. Specific binding ...


3
Bradley J Stringer, Gary A Simmons, Douglas A Christensen, Shayne Messerly, Cameron P Ford, Robert W Evensen: Ultrasonic vascular imaging system and method of blood vessel cannulation. Inceptio Medical Technologies, TraskBritt, June 29, 2004: US06755789 (99 worldwide citation)

An apparatus, method and system for cannulation of blood vessels. The apparatus comprises a sensor assembly including two linear transducer arrays oriented perpendicularly to each other to form a “T” shape to provide substantially simultaneous ultrasound images of at least one blood vessel in a port ...


4
Douglas A Christensen: Semiconductor temperature sensor. University of Utah, January 30, 1979: US04136566 (93 worldwide citation)

A temperature sensor utilizing a semiconductor sensing element which absorbs monochromatic radiant energy as a function of temperature. The apparatus includes a monochromatic radiant energy source, radiant energy guide means, a semiconductor sensing element interposed in the radiant energy guide mea ...


5
James N Herron, Douglas A Christensen, Karin D Caldwell, Vera Janatova, Shao Chie Huang, Hsu Kun Wang: Waveguide immunosensor with coating chemistry providing enhanced sensitivity. University of Utah Research Foundation, Trask Britt & Rossa, April 30, 1996: US05512492 (90 worldwide citation)

Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide and optionally has multi-well features and improved evanescent field intensity. The preferred biosensor and assay method have the capture molecules immobilized to the waveguide surfa ...


6
Steven A Johnson, James W Wiskin, David T Borup, Douglas A Christensen, Frank Stenger: Apparatus and method for imaging with wavefields using inverse scattering techniques. Workman Nydegger & Seeley, December 24, 1996: US05588032 (86 worldwide citation)

An apparatus and method for rapid real time imaging with wavefield energy by inverse scattering using a C.P.U programmed to process data derived from wavefield energy that has been transmitted and scattered by an object so as to reconstruct a wavefield image of the object. Electronic signals are pro ...


7
James N Herron, Douglas A Christensen, Jacob D Durtschi: Diagnostic device and method. University of Utah Research Foundation, Trask Britt, April 24, 2001: US06222619 (83 worldwide citation)

A method and apparatus of diagnosing a cardiac disease state in as little as two minutes involving the utilization of an evanescent wave assay system in conjunction with a data acquisition and analysis procedure that monitors the precision of assay results in real time (i.e., while data is being acq ...


8

9
James N Herron, Douglas A Christensen, Karin D Caldwell, Vera Janatová, Shao Chie Huang, Hsu Kun Wang: Apparatus for multichannel fluorescent immunoassays. University of Utah Research Foundation, TraskBritt, January 22, 2002: US06340598 (77 worldwide citation)

Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide and optionally has multi-well features and improved evanescent field intensity. The preferred biosensor and assay method have the capture molecules immobilized to the waveguide surfa ...


10
James N Herron, Douglas A Christensen, Victor A Pollak, Richard D McEachern, Eric M Simon: Lens and associatable flow cell. University of Utah Research Foundation, Trask Britt, August 22, 2000: US06108463 (74 worldwide citation)

Improvements in a biosensor of the type having reservoirs or wells for analyzing a biological liquid are disclosed. A biosensor (190) includes a waveguide (164) placed between a plurality of members such as plates (100, 186), at least one of the members (100) being formed to define the walls (132, 1 ...