1

2

3
James Doherty
Dorn Conrad P, Finke Paul E, Maccoss Malcolm, Doherty James B, Shah Shrenik K, Hagmann William K: New substituted azetidinones as anti-inflammatory and antidegenerative agents.. Merck & Co, April 22, 1992: EP0481671-A1 (40 worldwide citation)

New substituted azetidinones of the general formula (A') which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described. e


4
Dorn Conrad P, Hale Jeffrey J, Maccoss Malcolm, Mills Sander G, Ladduwahetty Tamara, Shah Shrenik K: Morpholine and thiomorpholine tachykinin receptor antagonists.. Merck & Co, January 5, 1994: EP0577394-A1 (78 worldwide citation)

Substituted heterocycles of the general structural formula: are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, and asthma and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.


5
Dorn Conrad P: Novel forms of diflunisal and related compounds.. Merck & Co, June 29, 1983: EP0082404-A1 (8 worldwide citation)

1-(alkoxy or aroxy)carbonyloxyalkyl esters of structural formula (I): wherein: R is (a) lower alkyl; (b) lower cycloalkyl; (c) unsubstituted or substituted aryl; or (d) aralkyl; R is (a) hydrogen; (b) lower alkyl; (c) lower cycloalkyl; or (d) aryl; R is (a) hydrogen; (b) lower alkanoyl; (c) lower al ...


6
Doherty James B, Finke Paul E, Dorn Conrad P, Maccoss Malcolm, Durette Philippe L, Mills Sander G, Shah Shrenik K, Lanza Thomas J, Sahoo Soumya P, Hagmann William K, Hale Jeffrey J: New substituted azetidinones as anti-inflammatory and antidegenerative agents.. Merck & Co, May 4, 1994: EP0595557-A1 (3 worldwide citation)

Substituted azetidinones of the general Formula (I) which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents, wherein R4 is (a) b) where Rx is carboxy C1-6alkyl, benzyloxycarbonylC1-3alkyl, or t-butoxycarbonylC1-3alkyl, wherein Q is a co ...


7
Doherty James B, Dorn Conrad P, Witzel Bruce E, Allison Debra L, Shen Tsung Ying, Finke Paul E: Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents.. Merck & Co, January 5, 1983: EP0068460-A1 (3 worldwide citation)

Compounds having the structural formula: are disclosed wherein there are 0-4 R groups and R is e.g. hydrogen, lower alkyl, halo-loweralkyl, hydroxy, lower alkoxy, halo, lower alkylthio or lower alkylsulfinyl; R is e.g. hydrogen or lower alkyl; Z is (a) -(CH2)0-n, n being 0-10; (b) -CO(CH2)1-n; (c) - ...


8
Dorn Conrad P, Durette Philippe L, Shen T Y: Immunostimulatory dipeptidyl d-glucose derivatives and methods of preparation.. Merck & Co, September 12, 1984: EP0118364-A1 (2 worldwide citation)

Compounds of the general formula: wherein R1, R2 and R3 are independently H or -@CH3; R4 is -@CH3 or an acoxycarbonyl group of the formula: -C@-O-R10 wherein R10 is C1-50 alkyl; 1- or 2-adamantyl; or 3-cholesteryl; R is H or C1-10 alkyl; provided that when R5 is C1-10 alkyl, the stereochemistry at c ...


9
Dorn Conrad P, Powles Mary Ann, Walsh Thomas F, Wyvratt Matthew J: Aminoalkylphenols, methods of using and making the same. Merck & Co, Dorn Conrad P, Powles Mary Ann, Walsh Thomas F, Wyvratt Matthew J, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, December 31, 2003: WO/2004/000783 (2 worldwide citation)

The present invention relates to Mannich base antimalarial aminoalkylphenol compounds and their use against protozoa of the genus Plasmodium, particularly emerging strains of drug-resistant Plasmodia. This invention further relates to compositions containing such compounds and a process for making t ...


10
Doherty James B, Chang Michael N, Dorn Conrad P: Pyrrole compounds as anti-inflammatory and analgesic agents.. Merck & Co, February 16, 1983: EP0072013-A1 (1 worldwide citation)

Pyrrole compounds of the structural formula: or a pharmaceutically acceptable salt, ester or amide thereof have been prepared via hydrolysis of a precursor-ester after high temperature decarboxylation of from direct acidic decarboxylation of a precursor diacid. In the above formula, Ar is phenyl, su ...



Click the thumbnails below to visualize the patent trend.