1
Paul R Meers, Charles Pak, Shaukat Ali, Andrew Janoff, J Craig Franklin, Ravi K Erukulla, Donna Cabral Lilly: Peptide-lipid conjugates. The Liposome Company, Rosanne Goodman, July 11, 2000: US06087325 (52 worldwide citation)

Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat ma ...


2
Paul R Meers, Charles Pak, Shaukat Ali, Andrew Janoff, J Craig Franklin, Ravi K Erukulla, Donna Cabral Lilly, Patrick L Ahl: Peptide-lipid conjugates, liposomes and lipsomal drug delivery. Elan PharmaceuticalsTechnologies, Burns Doane Swecker & Mathis L, January 15, 2002: US06339069 (41 worldwide citation)

Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat ma ...


3
Paul R Meers, Tong Shangguan, Donna Cabral Lilly, Patrick Ahl, Ravi Erukulla, Andrew Janoff: Modular targeted liposomal delivery system. Transave, Foley Hoag, June 13, 2006: US07060291 (12 worldwide citation)

A liposome including a fusogenic liposome, a linking moiety and a targeting moiety. The fusogenic liposome is a lipid bilayer encapsulating contents. The linking moiety is electrostatically bound to the lipid bilayer, and the targeting moiety is covalently bound to the linking moiety. The liposome m ...


4
Paul R Meers, Charles Pak, Shaukat Ali, Andrew Janoff, J Craig Franklin, Ravi K Erukulla, Donna Cabral Lilly: Liposomal peptide-lipid conjugates and delivery using same. The Liposome Company, Rosanne Goodman, November 7, 2000: US06143716 (8 worldwide citation)

Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat ma ...


5
Paul R Meers, Tong Shangguan, Donna Cabral Lilly, Patrick Ahl, Andrew S Janoff: Encapsulation of bioactive complexes in liposomes. Transave, Foley Hoag, February 17, 2009: US07491409 (4 worldwide citation)

This invention provides a method to prepare liposome-encapsulated bioactive agents such as nucleic acids, comprising complexation of the bioactive agents in reverse micelles prior to forming liposomes, as well as methods of using the liposomes so formed and formulations to deliver nucleic acids to c ...


6
Donna Cabral Lilly, Lawrence Mayer, Paul Tardi, David Watkins, Yi Zeng: Method of lyophilizing liposomes. CELATOR PHARMACEUTICALS, Morrison & Foerster, January 1, 2019: US10166184

Lyophilized liposomal formulations with two or more encapsulated drugs are disclosed. These formulations display superior drug retention profiles and also maintain size distribution following lyophilization and reconstitution.


7
Donna Cabral Lilly, Lawrence Mayer, Paul Tardi, David Watkins, Yi Zeng: Method of lyophilizing liposomes. CELATOR PHARMACEUTICALS, Morrison & Foerster, July 24, 2018: US10028912

Lyophilized liposomal formulations with two or more encapsulated drugs are disclosed. These formulations display superior drug retention profiles and also maintain size distribution following lyophilization and reconstitution.


8
Paul Meers, Tong Shangguan, Donna Cabral Lilly, Andrew Janoff, Patrick Ahl: Encapsulation of Bioactive Complexes in Liposomes. Foley Hoag, Patent Group World Trade Center West, March 12, 2009: US20090068256-A1

This invention provides a method to prepare liposome-encapsulated bioactive agents, such as nucleic acids, comprising complexation of the bioactive agents to reverse micelles prior to forming liposomes, as well as methods of using the liposomes so formed and formulations to deliver nucleic acids to ...


9
Paul Tardi, Lawrence Mayer, Donna Cabral Lilly: Lipid carrier compositions with reduced poly-dispersity. Morrison & Foerster, April 16, 2009: US20090098196-A1

The invention relates to a method for reducing the polydispersity of a population of gel-phase lipid-based delivery vehicles.


10
Paul R Meers, Tong Shangguan, Donna Cabral Lilly, Patrick Ahl, Ravi Erukulla, Andrew Janoff: Modular targeted liposomal delivery system. Transave, Foley Hoag, Patent Group World Trade Center West, August 3, 2006: US20060172003-A1

A liposome including a fusogenic liposome, a linking moiety and a targeting moiety. The fusogenic liposome is a lipid bilayer encapsulating contents. The linking moiety is electrostatically bound to the lipid bilayer, and the targeting moiety is covalently bound to the linking moiety. The liposome m ...