1
Chun Li, Sidney Wallace, Dong Fang Yu, David J Yang: Water soluble paclitaxel prodrugs. PG TXL Company, Arnold White & Durkee, November 2, 1999: US05977163 (219 worldwide citation)

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble chelator, polyethylene glycol or polymer such as poly (1-glutamic acid) or poly (1-aspartic acid). Also disclosed are methods of using the compositions for treatm ...


2
Chun Li, Sidney Wallace, Dong Fang Yu, David Yang: Water soluble paclitaxel derivatives. PG TXL Company, Foley & Lardner, May 4, 2004: US06730699 (115 worldwide citation)

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune d ...


3
Chun Li, Sidney Wallace, Dong Fang Yu, David J Yang: Water soluble paclitaxel prodrugs. PG TXL Company, Foley & Lardner, July 17, 2001: US06262107 (63 worldwide citation)

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble chelator, polyethylene glycol or polymer such as poly (1-glutamic acid) or poly (1-aspartic acid). Also disclosed are methods of using the compositions for treatm ...


4
Chun Li, Sidney Wallace, Dong Fang Yu, David Yang: Water soluble paclitaxel derivatives. PG TXL Company, Foley & Lardner, February 4, 2003: US06515017 (39 worldwide citation)

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune d ...


5
Chun Li, Sidney Wallace, Dong Fang Yu, David J Yang: Water soluble paclitaxel derivatives. PG TXL Company, Foley & Lardner, August 27, 2002: US06441025 (36 worldwide citation)

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune d ...


6
David J Yang, Chun W Liu, Dong Fang Yu, E Edmund Kim: Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging. Board of Regents University of Texas System, Fullbright & Jaworski L, June 27, 2006: US07067111 (29 worldwide citation)

The invention provides, in a general sense, a new labeling strategy employing 99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99mTc for use as an imaging agent for tissue-specific diseases. The drug conjugates of the invention may also be used ...


7
David J Yang, Chun W Liu, Dong Fang Yu, E Edmund Kim: Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging. Board of Regents The University of Texas System, Fulbright & Jaworski L, May 29, 2007: US07223380 (27 worldwide citation)

The invention provides, in a general sense, a new labeling strategy employing 99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99mTc for use as an imaging agent for tissue-specific diseases. The drug conjugates of the invention may also be used ...


8
Chun Li, Sidney Wallace, Dong Fang Yu, David J Yang: Water soluble paclitaxel derivatives. PG TXL Company, Foley & Lardner, April 26, 2005: US06884817 (26 worldwide citation)

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune d ...


9
David J Yang, Dong Fang Yu, Ali Azhdarinia, Tommy L Lee, E Edmund Kim: Local regional chemotherapy and radiotherapy using in situ hydrogel. Board of Regents The University of Texas System, Fulbright & Jaworski, March 7, 2006: US07008633 (25 worldwide citation)

Methods regarding local regional treatment in situ for an individual, such as of a tumor, are provided herein. A hydrogel composition is generated in situ in the tumor by administering a polymer, such as a polysaccharide or a polyamino acid, with a therapeutic agent, such as a radionuclide or a drug ...


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