1
Mary E Abreu, Waclaw Rzeszotarski, Donald J Kyle, Roger N Hiner, Richard L Elliott: Corticotropin-releasing factor antagonism compounds. Nova Pharmaceutical Corporation, Vincent L Fabiano, November 5, 1991: US05063245 (62 worldwide citation)

The present invention relates to a method of producing corticotropin-releasing factor (CRF) antagonist activity and thus provides a method of treating a wide range of stress-related disorders, including affective illnesses, such as depression and anxiety, as well as irritable bowel syndrome, anorexi ...


2
Waclaw J Rzeszotarski, Donald J Kyle: Antagonists of specific excitatory amino acid neurotransmitter receptors having increased potency. Nova Pharmaceutical Corporation, Breneman & Georges, August 2, 1988: US04761405 (26 worldwide citation)

The invention pertains to novel, potent anticonvulsants, analgesics, cognition enhancers and neuroprotectants achieving their action through the antagonism of specific excitatory amino acid neurotransmitter receptors. In particular, the invention is directed to .omega.-[2-(phosphonoalkylenyl)-cycloa ...


3
Donald J Kyle, Qun Sun: 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain. Euro Celtique, Jones Day, December 13, 2005: US06974818 (17 worldwide citation)

A compound of formula: (wherein X is O or S and R1, R3, R4, and R5 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Thiadiazolylpiperazine Compound”), pharmaceutical compositions comprising a Thiadiazolylpiperazine Compound, and methods for treating or preventing pain in a pat ...


4
Qun Sun, Xiaoming Zhou, Donald J Kyle: Aryl substituted benzimidazoles and their use as sodium channel blockers. Euro Celtique, Sterne Kessler Goldstein & Fox P L L C, April 4, 2006: US07022714 (16 worldwide citation)

This invention relates aryl substituted benzimidazoles of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein R1, R2, R10 and n are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage ...


5
R Richard Goehring, Sam F Victory, Donald J Kyle: Aryl substituted pyrimidines and the use thereof. Euro Celtique, Sterne Kessler Goldstein & Fox P L L C, June 12, 2007: US07229993 (15 worldwide citation)

This invention relates to a method of treating disorders responsive to the blockade of sodium ion channels using novel aryl-substituted pyrimidine compounds of Formula I: or a pharmaceutically acceptable salt, or solvate thereof, wherein A, R1, R2, R3 and R4 are defined in the specification. The inv ...


6
Qun Sun, Donald J Kyle, Parviz Gharagozloo, Ji Yang: Aryl substituted thiazolidinones and the use thereof. Euro Celtique, Sterne Kessler Goldstein & Fox P L L C, January 30, 2007: US07169782 (15 worldwide citation)

This invention relates aryl substituted thiazolidinones of Formula I: or a pharmaceutically acceptable salt, or solvate thereof, wherein R1 and R2, are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following glo ...


7
Donald J Kyle, Qun Sun, Laykea Tafesse: Therapeutic agents useful for treating pain. Purdue Pharma, Sterne Kessler Goldstein & Fox PLLC, March 23, 2010: US07683063 (13 worldwide citation)

A compound of formula: wherein Ar1, Ar2, V, X, R3, R4, and m are as disclosed herein or a pharmaceutically acceptable salt thereof (a “Cyclo(hetero)alkenyl Compound”); compositions comprising an effective amount of a Cyclo(hetero)alkenyl Compound; and methods for treating or preventing, e.g., pain, ...


8
Donald J Kyle, Qun Sun, Laykea Tafesse, Chongwu Zhang, Xiaoming Zhou: Therapeutic agents useful for treating pain. Euro Celtique, Jones Day, October 9, 2007: US07279493 (12 worldwide citation)

A compound of formula: wherein A, Ar, R3, R6, and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Cyanoiminopiperazine Compound”), compositions comprising an effective amount of a Cyanoiminopiperazine Compound, and methods for treating or preventing pain, urinary incontinen ...


9
Donald J Kyle, Qun Sun: 1,2,5-Thiadiazol-3-yl-piperazine therapeutic agents useful for treating pain, depression and anxiety. Euro Celtique, Jones Day, March 11, 2008: US07342017 (12 worldwide citation)

A compound of formula: (wherein X, R1, R3, R4, and R5 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Thiadiazolylpiperazine Compound”), pharmaceutical compositions comprising a Thiadiazolylpiperazine Compound, and methods for treating or preventing, e.g., pain, depression an ...


10
Donald J Kyle, Roger N Hiner: Bradykinin antagonist peptides. Scios Nova, Nath Amberly & Associates, January 31, 1995: US05385889 (12 worldwide citation)

The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with a D-configuration hydroxyproline ether or thioether converts bradykinin agonists into bradykinin antagonists. The invention further includes the intermediate compounds an ...



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