1
Donald J Hnatowich: Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product. Trustees of the University of Massachusetts, Paul J Cook, Lawrence Gilbert, October 30, 1984: US04479930 (78 worldwide citation)

A dicyclic dianhydride rapidly and efficiently couples with a broad variety of amines such as polypeptides and proteins in non-aqueous or aqueous media and then may be chelated with a wide choice of radioisotope metallic cations to yield a radio-labeled product that is stable in vivo. A simple 1-ste ...


2
Charles R Cantor, Christof M Niemeyer, Cassandra L Smith, Takeshi Sano, Donald J Hnatowich, Mary Rusckowski: Self-assembling multimeric nucleic acid constructs. Trustees of Boston University, James Remenick, Baker & Botts L, October 1, 1996: US05561043 (45 worldwide citation)

The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify d ...


3
Charles R Cantor, Christof M Niemeyer, Cassandra L Smith, Takeshi Sano, Donald J Hnatowich, Mary Rusckowski: Self-assembling multimeric nucleic acid constructs. Trustees of Boston University, Univ of Mass Medical Center, Medlen & Carroll, October 12, 1999: US05965133 (19 worldwide citation)

The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify d ...


4

5
Donald J Hnatowich, Mary Rusckowski, Guozheng Liu: Morpholino imaging and therapy. Immunomedics, Heller Ehrman White and McAuliffe, May 31, 2005: US06899864 (6 worldwide citation)

The present invention provides a kit and a method for targeting of a diagnostic or therapeutic agent to a target site in a mammal having a pathological condition. The kit comprises, in separate containers, (a) a first conjugate comprising a targeting moiety and a Morpholino oligomer, wherein the tar ...


6
Donald J Hnatowich, Mary Rusckowski, Guozheng Liu: Morpholino imaging and therapy. University of Massachusetts, Stephen B Maebius, Foley & Lardner Washington Harbour, January 2, 2003: US20030003102-A1

The present invention provides a kit and a method for targeting of a diagnostic or therapeutic agent to a target site in a mammal having a pathological condition. The kit comprises, in separate containers, (a) a first conjugate comprising a targeting moiety and a Morpholino oligomer, wherein the tar ...


7
Donald J Hnatowich, Mary Rusckowski: Bacteriophage imaging of inflammation. Fish & Richardson PC, November 17, 2005: US20050255043-A1

Labeled bacteriophage are disclosed which are useful for detecting a bacterial infection in vivo.