1
Woonza Rhee, Donald G Wallace, Alan S Michaels, Ramon A Burns Jr, Louis Fries, Frank DeLustro, Hanne Bentz: Collagen-polymer conjugates. Collagen Corporation, Morrison & Foerster, November 10, 1992: US05162430 (474 worldwide citation)

Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer.


2
Donald G Wallace, Cary J Reich, Narinder S Shargill, Felix Vega, A Edward Osawa: Fragmented polymeric compositions and methods for their use. Fusion Medical Technologies, Townsend and Townsend and Crew, May 23, 2000: US06066325 (326 worldwide citation)

Cross-linked hydrogels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such hydrogels preferably have no free aqueous phase and may be applied to target sites in a patient's body by extruding the hydrogel through an orifice at the ...


3
Donald G Wallace, Hertsel Reihanian, Bruce B Pharriss, William G Braun: Injectable implant composition having improved intrudability. Collagen Corporation, Ciotti & Murashige Irell & Manella, February 7, 1989: US04803075 (287 worldwide citation)

Injectable aqueous suspensions of biomaterials, such as cross-linked collagen, that contain a biocompatible fluid lubricant, such as glycogen or maltose, are disclosed. The inclusion of the lubricant significantly improves the intrusion of the suspension into soft tissue.


4
Woonza Rhee, Donald G Wallace, Alan S Michaels, Ramon A Burns Jr, Louis Fries, Frank DeLustro, Hanne Bentz: Collagen-polymer conjugates. Collagen Corporation, Karl Bozicevic, July 12, 1994: US05328955 (277 worldwide citation)

Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The atelopeptide collagen can be type I, type II or ...


5
Thomas L Smestad, John McPherson, Donald G Wallace: Injectable cross-linked collagen implant material. Collagen Corporation, Ciotti & Murashige, April 15, 1986: US04582640 (271 worldwide citation)

Cross-linked atelopeptide collagen that is substantially free of residual cross-linking agent is prepared by: reconstituting atelopeptide collagen from solution by neutralizing the solution at a reduced temperature and a hypotonic ionic strength; cross-linking the reconstituted fibers in an aqueous ...


6
Donald G Wallace, Susan B Wade: Collagen implant material and method for augmenting soft tissue. Collagen Corporation, Ciotti & Murashige, January 3, 1984: US04424208 (266 worldwide citation)

An injectable implant material for soft tissue augmentation comprising a dispersion of (a) particles of cross-linked atelopeptide collagen; and (b) reconstituted fibrous atelopeptide collagen in a (c) physiological aqueous carrier. Implants of this material have improved persistence relative to curr ...


7
Woonza Rhee, Donald G Wallace, Alan S Michaels, Ramon A Burns Jr, Louis Fries, Frank DeLustro, Hanne Bentz: Biologically inert, biocompatible-polymer conjugates. Collagen Corporation, Karl Bozicevic, June 28, 1994: US05324775 (265 worldwide citation)

Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding biologically inactive, natural, biocompatible polymer to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide biocompatible conjugates. The synthetic hydrophil ...


8
Donald G Wallace, Gregory M Cruise, Woonza M Rhee, Jacqueline Anne Schroeder, George T Coker III, Marcee M Maroney: Rapid gelling biocompatible polymer composition. Cohesion Technologies, Dianne E Reed, Laurie A Axord, November 6, 2001: US06312725 (205 worldwide citation)

This invention relates generally to two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired. In particular, ...


9
Philip N Sawyer, Donald G Wallace, Ronald K Yamamoto: Method for bonding or fusion of biological tissue and material. Fusion Medical Technologies, Townsend and Townsend and Crew, May 12, 1998: US05749895 (184 worldwide citation)

Biological materials are joined, repaired or fused by heating the material in proximity to a mechanical support. Preferably, the mechanical support comprises a patch or bridge structure. In the most preferred embodiment, the patch is formed from collagen having a thickness from between 2 to 30 mils, ...


10
Donald G Wallace, Thomas L Smestad, John M McPherson, Karl A Piez, Saeid Seyedin, Rosa Armstrong: Methods of bone repair using collagen. Collagen Corporation, Ciotti & Murashige Irell & Manella, December 6, 1988: US04789663 (175 worldwide citation)

A method of repairing bone defects by use of suspensions containing purified atelopeptide, reconstituted, fibrillar skin collagen or bone collagen powder or mixtures thereof is disclosed. The suspensions provide matrices for conductive growth of bone into the defect. The skin collagen may also be ly ...



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