1
Dominique P Bridon, Benoit L&apos Archeveque, Alan M Ezrin, Darren L Holmes, Anouk Leblanc, Serge St Pierre: Long lasting insulinotropic peptides. Conjuchem, Morrison & Foerster, December 11, 2001: US06329336 (83 worldwide citation)

Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates ...


2
Dominique P Bridon, Alan M Ezrin, Peter G Milner, Darren L Holmes, Karen Thibaudeau: Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components. ConjuChem, Morrison & Foerster, February 1, 2005: US06849714 (79 worldwide citation)

A method of synthesizing a modified therapeutic peptide capable of forming a peptidase-stabilized therapeutic peptide conjugate, the peptide having between 3 and 50 amino acids, is k. In a first step of the method, a therapeutic peptide having a carboxy terminal amino acid and amino terminal amino a ...


3
Dominique P Bridon, Benoit L&apos Archeveque, Alan M Ezrin, Darren L Holmes, Anouk Leblanc, Serge St Pierre: Long lasting synthetic glucagon like peptide {GLP-!}. Conjuchem, Morrison & Foerster, February 4, 2003: US06514500 (76 worldwide citation)

Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates ...


4
Alan M Ezrin, Angelica Fleser, Martin Robitaille, Peter G Milner, Dominique P Bridon: Pulmonary delivery for bioconjugation. Conjuchem, Morrison & Foerster, March 16, 2004: US06706892 (64 worldwide citation)

Methods of and compositions for pulmonary delivery of therapeutic agents which are capable of forming covalent bonds with a site of interest or which have formed a covalent bond with a pulmonary solution protein are disclosed. Therapeutic agents useful in the invention include wound healing agents, ...


5
Dominique P Bridon, Alan M Ezrin, Peter G Milner, Darren L Holmes, Karen Thibaudeau: Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components. Conjuchem, Morrison & Foerster, May 3, 2005: US06887470 (60 worldwide citation)

A method for protecting a peptide from peptidase activity in vivo, the peptide being composed of between 2 and 50 amino acids and having a C-terminus and an N-terminus and a C-terminus amino acid and an N-terminus amino acid is described. In the first step of the method, the peptide is modified by a ...


6
Dominique P Bridon, Benoit L&apos Archeveque, Alan M Ezrin, Darren L Holmes, Anouk Leblanc, Serge St Pierre: Long lasting synthetic glucagon-like peptide (GLP-1). ConjuChem, Morrison & Foerster, November 23, 2004: US06821949 (44 worldwide citation)

Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates ...


7
Dominique P Bridon, Benoit L&apos Archeveque, Alan M Ezrin, Darren L Holmes, Anouk Leblanc, Serge St Pierre: Long lasting insulinotropic peptides. Conjuchem, Morrison & Foerster, July 15, 2003: US06593295 (41 worldwide citation)

Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates ...


8
Dominique P Bridon, Benoit L Archeveque, Alan M Ezrin, Darren L Holmes, Anouk Leblanc, Serge St Pierre: Long lasting synthetic glucagon-like peptide {GLP-1}. ConjuChem, Morrison & Foerster, May 3, 2005: US06887849 (35 worldwide citation)

Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates ...


9
Dominique P Bridon, Alan Ezrin, Peter Milner: Methods of treating or preventing thromboses. ConjuChem, Limbach & Limbach, July 11, 2000: US06087375 (20 worldwide citation)

Novel compounds comprising chemically reactive intermediates which can react with available reactive functionalities on blood components to form covalent linkages, where the resulting covalently-bound conjugates are found to have thrombin inhibition activity are provided. Specifically, the thrombin ...


10
Alan M Ezrin, Dominique P Bridon, Darren L Holmes, Peter G Milner: Conjugate comprising an antinociceptive agent covalently bonded to a blood component. Conjuchem, Morrison & Foerster, December 31, 2002: US06500918 (18 worldwide citation)

Conjugates are prepared from antinociceptive agents, particularly opioids or opioid analogs, more particularly dynorphins, endorphins, deltorphins, enkephalins or analogs thereof, by combining said antinociceptive agent with a material providing a functionally reactive group capable of reacting with ...



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