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James Doherty
Dorn Conrad P, Finke Paul E, Maccoss Malcolm, Doherty James B, Shah Shrenik K, Hagmann William K: New substituted azetidinones as anti-inflammatory and antidegenerative agents.. Merck & Co, April 22, 1992: EP0481671-A1 (40 worldwide citation)

New substituted azetidinones of the general formula (A') which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described. e


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Chen Meng Hsin, Doherty James B, Liu Luping, Natarajan Swaminathan R, Shen Dong Ming, Shu Min: Ophthalmic compositions for treating ocular hypertension. Merck & Co, Chen Meng Hsin, Doherty James B, Liu Luping, Natarajan Swaminathan R, Shen Dong Ming, Shu Min, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, January 13, 2005: WO/2005/002520 (22 worldwide citation)

This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotecti ...


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Doherty James B, Finke Paul E, Firestone Raymond A, Hagmann William K, Shah Shrenik K, Thompson Kevan R: New substituted cephalosporin sulfones as antiinflammatory and antidegenerative agents, pharmaceutical compositions containing the same and processes for making them.. Merck & Co, November 7, 1984: EP0124081-A2 (19 worldwide citation)

New substituted cephalosporin sulfones are disclosed having the structural formula: wherein M is, e.g., trifluoromethyl, chloro or fluoro or -COOH; R1 is, e.g., hydrogen, hydroxy, mercapto, substituted oxy, substituted thio, hydrocarbyl or substituted hydrocarbyl group; B is OB1, or NB2B3 wherein B1 ...


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Doherty James B, Shu Min, Shen Dong Ming, Zhang Fengqi: Ophthalmic compositions for treating ocular hypertension. Merck & Co, Doherty James B, Shu Min, Shen Dong Ming, Zhang Fengqi, MERCK 126 East Lincoln Avenue Rahway New Jersey 07065 0907, September 27, 2007: WO/2007/108968 (18 worldwide citation)

This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotecti ...


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Doherty James B, Finke Paul E, Firestone Raymond A, Hagmann William K, Thompson Kevan R, Shah Shrenik K: New substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents.. Merck & Co, May 18, 1988: EP0267723-A2 (15 worldwide citation)

New substituted cephalosporin sulfones with structural formula: are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.


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Davies Philip, Doherty James B, Finke Paul E, Humes John L, Leudke Edward S, Maccoss Malcolm, Mumford Richard A, Shah Shrenik K: Substituted azetidinones useful in the treatment of leukemia. Merck & Co, November 3, 1993: GB2266527-A (12 worldwide citation)

Compounds of formula I and salts thereof, wherein R is C1-6alkyl; R is C1-6alkyl or C1-6alkoxy-C1-6alkyl; and M, X5, X6, X7 and X8 are hydrogen or specific substituents, are useful in the treatment of leukemia.


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Shen Dong Ming, Doherty James B: Ophthalmic compositions for treating ocular hypertension. Merck & Co, Shen Dong Ming, Doherty James B, MERCK 126 East Lincoln Avenue Rahway New Jersey 07065 0907, March 10, 2005: WO/2005/020917 (10 worldwide citation)

This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a n ...


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Thompson Kevan R, Finke Paul E, Doherty James B: Penicillin derivatives as anti-inflammatory and antidegenerative agents.. Merck & Co, February 5, 1986: EP0170192-A1 (7 worldwide citation)

Derivatives of Penicillin, their sulfoxides and sulfones of the structural formula: wherein q is 0, 1 or 2; A is, e.g., CH3 or CH2O(CO)CH3; R1 is, e.g., R min NRa wherein Ra is H or C1-6alkyl and R min is, e.g., hydrogen or R - (CH2)n -@- where R represents: (i) hydrogen; (ii) C1-6alkyl; (iii) trifl ...



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