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Dirk Kosemund, Gerd Mueller, Alexander Hillisch, Karl Heinrich Fritzemeier, Peter Muhn: 9-α-substituted estratrienes as selectively active estrogens. Schering, Millen White Zelano & Branigan P C, August 19, 2008: US07414043 (14 worldwide citation)

This invention describes the new 9α-substituted estratrienes of general formula I in which R3, R7, R7′, R13, R16 as well as R17 and R17′ have the meanings that are indicated in the description and R9 means a straight-chain or branched-chain, optionally partially or completely halogenated alkenyl rad ...


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Alexander Hillisch, Olaf Peters, Christian Gege, Wilko Regenhardt, Dirk Kosemund, Gerhard Siemeister, Eberhard Unger, Ulrich Bothe: 2-substituted estra-1,3,5(10)-triene-3-yl sulfamate with an anti-tumour action. Sterix, Millen White Zelano & Branigan P C, September 23, 2008: US07427610 (2 worldwide citation)

Disclosed are compounds of formula I and use thereof in a method of treating a tumor disease that can be influenced positively by the inhibition of tubulin polymerization.


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Hermann Kuenzer, Rudolf Knauthe, Monika Lessl, Karl Heinrich Fritzemeier, Christa Hegele Hartung, Ulf Boemer, Gerd Mueller, Dirk Kosemund: 16-hydroxyestratrienes as selectively active estrogens. Schering, Millen White Zelano & Branigan P C, September 19, 2006: US07109360 (2 worldwide citation)

The invention describes new compounds as pharmaceutical active ingredients, which have in vitro a higher affinity to estrogen receptor preparations from rat prostates than to estrogen receptor preparations from rat uteri and in vivo a preferential action on bone rather than the uterus, their product ...


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Bernd Buchmann, Dirk Kosemund, Bernd Menzenbach, Martin Fritsch: Inhibitors of soluble adenylate cyclase. Bayer Schering Pharma, Millen White Zelano Branigan P C, November 11, 2008: US07449459 (2 worldwide citation)

The invention relates to compounds of general formula I as well as the production and use thereof as a medication.


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Ulrich Klar, Marcus Koppitz, Rolf Jautelat, Dirk Kosemund, Rolf Bohlmann, Philip Lienau, Gerhard Siemeister, Antje Margret Wengner: Substituted imidazopyridazines. BAYER INTELLECTUAL PROPERTY, February 9, 2016: US09255100 (1 worldwide citation)

The present invention relates to substituted imidazopyridazine compounds of general formula (I), which are Mps-1 (Monopolar Spindle 1) Kinase inhibitors (also known as Tyrosine Threonine Kinase, TTK) in which R3, R5, and A are as defined in the claims, to methods of preparing said compounds, to phar ...


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Ulrich Lücking, Dirk Kosemund, Arne Scholz, Philip Lienau, Gerhard Siemeister, Ulf Bömer, Rolf Bohlmann: Disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group. Bayer Intellectual Property, September 15, 2015: US09133171 (1 worldwide citation)

The present invention relates to disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative d ...


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Volker Schulze, Knut Eis, Lars Wortmann, Dirk Kosemund, Olaf Prien, Gerhard Siemeister, Holger Hess Stumpp, Uwe Eberspaecher, Damian O Arnaiz: Thiazolidinones, their production and use as pharmaceutical agents. Schering, Millen White Zelano & Branigan P C, March 31, 2009: US07511059 (1 worldwide citation)

The invention relates to thiazolidinones of general formula (I) their production and use as inhibitors of polo-like kinases (Plk) for treating various diseases.


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Marcus Koppitz, Ulrich Klar, Rolf Jautelat, Dirk Kosemund, Rolf Bohlmann, Benjamin Bader, Philip Lienau, Gerhard Siemeister: Substituted imidazo[1,2-a]pyrazines as MPS-1 inhibitors. Bayer Intellectual Property, March 15, 2016: US09284317 (1 worldwide citation)

The present invention relates to substituted imidazopyrazine compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined in the claims, to methods of and intermediates for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to t ...