1
Chien Hsing Chang, David M Goldenberg, Edmund A Rossi, Diane Rossi: T-cell redirecting bispecific antibodies for treatment of disease. IBC Pharmaceuticals, Richard A Nakashima, April 19, 2016: US09315567 (1 worldwide citation)

The present invention concerns compositions and methods of use of T-cell redirecting complexes, with at least one binding site for a T-cell antigen and at least one binding site for an antigen on a diseased cell or pathogen. Preferably, the complex is a DNL™ complex. More preferably, the complex com ...


2
Chien Hsing Chang, David M Goldenberg, Edmund A Rossi, Diane Rossi: Disease therapy by inducing immune response to Trop-2 expressing cells. IBC Pharmaceuticals, Richard A Nakashima, July 5, 2016: US09382329

The present invention concerns compositions and methods of use of bispecific antibodies comprising at least one binding site for Trop-2 (EGP-1) and at least one binding site for CD3. The bispecific antibodies are of use for inducing an immune response against a Trop-2 expressing tumor, such as carci ...