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James Doherty
Clifton John Blankley, Diane Harris Boschelli, Annette Marian Doherty, James Marino Hamby, Sylvester Klutchko, Robert Lee Panek: Pyrido�2, 3-d!pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation. Warner Lambert Company, Charles W Ashbrook, March 31, 1998: US05733914 (48 worldwide citation)

6-Aryl pyrido�2,3-d!pyrimidine 7-imines, 7-ones, and 7-thiones are inhibitors of protein tyrosine kinases, and are thus useful in treating cellular proliferation mediated thereby. The compounds are especially useful in treating cancer, atherosclerosis, restenosis, and psoriasis.


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Diane Harris Boschelli, Annette Marian Doherty, Ali Fattaey, David William Fry, Susanne Andrea Trumpp Kallmeyer, Zhipei Wu, Ellen Myra Dobrusin, Mark Robert Barvian: Pyrido[2,3-D]pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation. Warner Lambert Company, Charles W Ashbrook, Rosanne Goodman, December 24, 2002: US06498163 (43 worldwide citation)

This invention provides pyridopyrimidines and 4-aminopyrimidines that are useful for treating cell proliferative disorders, such as cancer and restenosis. We have now discovered a group of 7,8-dihydro-2-(amino and thio)pyrido[2,3-d]pyrimidines and 2,4-diaminopyrimidines that are potent inh ...


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Diane Harris Boschelli, William Alexander Denny, Annette Marian Doherty, James Marino Hamby, Sonya Shah Khatana, James Bernard Kramer, Brian Desmond Palmer, Howard Daniel Hollis Showalter: Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation. Warner Lambert Company, Todd M Crissey, November 23, 1999: US05990146 (22 worldwide citation)

Benzimidazoles of Formula I below are inhibitors of protein tyrosine kinases, and are useful in treating cellular proliferation. ##STR1## The compounds are especially useful in treating cancer, atherosclerosis, restenosis, and psoriasis.


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Diane Harris Boschelli, Yanong Daniel Wang, Steve Lawrence Johnson, Dan Maarten Berger: Process for the preparation of 7-substituted-3 quinolinecarbonitriles. Wyeth Holdings Corporation, Joy S Goudie, August 24, 2004: US06780996 (13 worldwide citation)

There is provided a process for the preparation of 7-substituted-3-quinolinecarbonitriles and intermediates useful in a process to prepare 7-substituted-3-quinolinecarbonitriles and pharmaceutically acceptable salts is described. Where 7-fluoro-4-oxo-1,4-dihydro-3-quinolinecarbonitrile is converted ...


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Karen Wiggins Sutherland, Gregg Brian Feigelson, Diane Harris Boschelli, David Michael Blum, Henry Lee Strong: Process for preparation of 4-amino-3-quinolinecarbonitriles. Wyeth Holdings Corporation, Stephen E Johnson, November 20, 2007: US07297795 (8 worldwide citation)

This invention discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile comprising combining an amine compound with a cyanoacetic acid and an acid catalyst to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline in an alcoholic ...


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Vijaykumar Baragi, Diane Harris Boschelli, David Thomas Connor, Richard Raymond Renkiewicz: Benzylidene-lactone derivatives of fenamates and their thiocarbonyl analogs as inhibitors of proteoglycan degradation. Warner Lambert Company, December 30, 1997: US05703119 (3 worldwide citation)

The manufacture and use of compounds of the formula ##STR1## wherein Y is O or S, R.sub.1 is hydrogen or alkyl, and R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are hydrogen or various substituent groups, and pharmaceutically acceptable acid addition salts thereof. The compounds have activity as inhibitors ...


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Vijaykumar Baragi, Diane Harris Boschelli, David Thomas Connor, Richard Raymond Renkiewicz, Howard Glenn Welgus: Method of inhibiting connective tissue degradation. Warner Lambert Company, Charles W Ashbrook, April 3, 2001: US06211209 (2 worldwide citation)

The present invention provides a method of inhibiting connective tissue degradation that comprises administering to a patient having a condition in which connective tissue is degraded a therapeutically effective amount of a compound having the formula