1
James Doherty
Clifton J Blankley, Diane H Boschelli, Annette M Doherty, James M Hamby, Sylvester Klutchko, Robert L Panek: Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation. Warner Lambert Company, Charles W Ashbrook, April 15, 1997: US05620981 (42 worldwide citation)

6-Aryl pyrido[2,3-d]pyrimidine 7-imines, 7-ones, and 7-thiones are inhibitors of protein tyrosine kinases, and are thus useful in treating cellular proliferation mediated thereby. The compounds are especially useful in treating cancer, atherosclerosis, restenosis, and psoriasis.


2
Diane H Boschelli, David T Connor, Paul C Unangst: Indole-2-carboxamides as inhibitors of cell adhesion. Warner Lambert Company, Ronald A Daignault, Charles W Ashbrook, June 13, 1995: US05424329 (35 worldwide citation)

3-Substituted-indole-2-carboxamides are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases. Certain of these compounds are novel and methods of manufacture are also described.


3
Diane H Boschelli, David T Connor, Sony S Khatana, James B Kramer, Paul C Unangst: 1-ether and 1-thioether-naphthalene-2-carboxamides as inhibitors of cell adhesion and as inhibitors of the activation of HIV. Warner Lambert Company, Charles W Ashbrook, July 18, 1995: US05434188 (20 worldwide citation)

1-Ether and 1-thioether-naphthalene-2-carboxamides are described, methods of manufacture therefor and their use as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases, and their utility in inhibiting the a ...


4
Diane H Boschelli, David T Connor, Clifford D Wright: 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo(b) thiophene-2-carboxamides as inhibitors of cell adhesion. Warner Lambert Company, Ronald A Daignault, May 4, 1993: US05208253 (17 worldwide citation)

3-Alkyloxy-, aryloxy-, or arylalkyloxy-benzo[b]thiophene-2-carboxamides are described as agents which block leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases. Certain of these compounds are novel and methods of preparation a ...


5
Diane H Boschelli, David T Connor, James B Kramer, Paul C Unangst: 3-thio or amino substituted-benzo[b]thiophene-2-carboxamides and 3-oxygen, thio, or amino substituted-benzofuran-2-carboxamides as inhibitors of cell adhesion. Warner Lambert Company, Ronald A Daignault, Charles W Ashbrook, September 27, 1994: US05350748 (15 worldwide citation)

3-Thio or amino substituted benzo[b]thiophene-2-carboxamides and 3-oxygen, thio, or amino substituted benzofuran-2-carboxamides are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases. Certain ...


6
John F Poletto, Dennis W Powell, Diane H Boschelli: Substituted quinolinecarboxylic acids. American Cyanamid Company, Alan M Gordon, November 6, 1990: US04968702 (14 worldwide citation)

Substituted quinolinecarboxylic acids useful in the treatment of arthritis by inhibiting the progressive joint deterioration characteristic of arthritic disease and for inducing immunosuppression are disclosed. Methods of synthesis and use of the novel compounds are also disclosed.


7
Diane H Boschelli, David T Connor, Richard D Dyer, Sonya S Khatana, James B Kramer, William H Roark: Method of selectively inhibiting prostaglandin G/H synthase-2. Warner Lambert Company, Todd M Crissey, November 5, 1996: US05571825 (12 worldwide citation)

The present invention provides a method of selectively inhibiting prostaglandin G/H synthase-2 that comprises administering to a patient in need of such inhibition an inhibiting amount of a compound having the Formula I, II or III ##STR1## wherein the R groups and heterocycles are defined in the dis ...


8
Diane H Boschelli, David T Connor, Daniel L Flynn, Jagadish C Sircar, Milton L Hoefle: Triazole derivatives of fenamates as antiinflammatory agents. Warner Lambert Company, Joan Thierstein, October 9, 1990: US04962119 (9 worldwide citation)

The present invention is novel compounds which are 1,2,4-triazoles, derivatives of fenamates and pharmaceutically acceptable additions and base salts thereof, pharmaceutical compositions and methods of use thereof. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenas ...


9
Thomas R Belliotti, Diane H Boschelli, David T Connor, Catherine R Kostlan: 2-substituted thiazolidinone, oxazolidinone, and imidazolidinone derivatives of fenamates as antiinflammatory agents. Warner Lambert Company, Joan Thierstein, September 1, 1992: US05143929 (8 worldwide citation)

The present invention is for selected novel compounds which are 2-substituted thiazolidinone, oxazolidinone, and imidazolidinone derivatives of fenamates, as well as pharmaceutical compositions and methods of use thereof. These compounds exhibit activity useful in treating allergies and inflammation ...


10
Diane H Boschelli, David T Connor, James B Kramer, Paul C Unangst: Benzothiophene, benzofuran and indole-thiazepinones, oxazepinones and diazepinones as inhibitors of cell adhesion and as inhibitors of HIV. Warner Lambert Company, Charles W Ashbrook, October 15, 1996: US05565446 (8 worldwide citation)

Benzothiophene, benzofuran and indolethiazepinones, oxazepinones and diazepinones as well as methods of preparation thereof are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases; these compo ...